Results 91 to 100 of about 36,721 (301)

Topography‐Regulated Screening Platform for Myoblast Contact Guidance

Advanced Materials Technologies, EarlyView.
This study develops a topography‐regulated screening platform (12 gradients in 96‐topography‐well plate) enabling analysis of skeletal muscle morphogenesis. The topography‐induced cell morphology changed, cell polarization, and myotube differentiation, establishing an evaluative framework for generating pathologically relevant myotube phenotypes to ...
Tianqi Feng, Torben A.B. van der Boon, Savannah Amy Haupt, Adam Jones, Yanjing Ji, Theo G. Van Kooten, Patrick van Rijn   +6 more
wiley   +1 more source

MOLECULES INVOLVED IN THE SPIDER, CUPIENNIUS SALEI, MECHANOTRANSDUCTION

, 2019
The molecular mechanisms involved in mechanical senses such as touch and vibration have been studied for decades using a small number of model preparations in species facilitating genetic manipulation.
Johnson, Jessica
core  

Tools to Examine Mechanotransduction

, 2018
Organisms experience acute and chronic mechanical forces. Acute mechanical stimulation in Drosophila induces the ectopic expression of developmental regulatory genes.
Ardon Shorr (4940233)
core   +1 more source

A small scale cell culture system to analyze mechanobiology using reporter gene constructs and polyurethane dishes [PDF]

European Cells & Materials, 2010
Mechanical forces are translated into biochemical signals and contribute to cell differentiation and phenotype maintenance. Mesenchymal stem cells and their tissue-specific offspring, as osteoblasts and chondrocytes, cells of cardiovascular tissues and ...
W Wilke, F Jakob, R Ebert, A Ignatius, M Schieker, L Claes, D Docheva, A Liedert, M Kassem, T Lind, B Mentrup, M Kober, T Schwarz, S Mueller-Deubert, L Seefried   +14 more
doaj  

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Lung Mechanotransduction, the minuet of Biophysics (Part 1)

The dynamic processes associated with lung pathophysiology have always been explored from a traditionalist perspective. This review conceptualizes an amalgam of biological and biophysical concepts that aim to optimize the understanding of the ...
Yolanda López-Fernández, Alberto Medina, Aurio Fajardo-Campoverdi, Miguel Ibarra-Estrada, Alejandro González-Castro, Elena Ortega, Paulina Vivanco   +6 more
core   +1 more source

Advanced Microarrays as Heterogeneous Force‐Remodeling Coordinator to Orchestrate Nuclear Configuration and Force‐Sensing Mechanotransduction in Stem Cells

Advanced Science
Integrin and focal adhesion can regulate cytoskeleton distribution to govern actin‐related force remodeling and play an important role in nuclear configuration and force‐sensing mechanotransduction of stem cells.
Nana Wang, Yan Hou, Lili Lin, Shihui Xu, Kyubae Lee, Yingjun Yang, Yazhou Chen, Yachun Li, Xiuhui Wang, Yongtao Wang, Tao Chen   +10 more
doaj   +1 more source

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

Thy-1 in Integrin Mediated Mechanotransduction [PDF]

, 2019
The glycosylphosphatidylinositol (GPI) anchored glycoprotein Thy-1 has been prevalently expressed on the surface of various cell types. The biological function of Thy-1 ranges from T cell activation, cell adhesion, neurite growth, differentiation ...
Thomas H. Barker, Ping Hu
core   +1 more source