Results 91 to 100 of about 40,337 (298)
Advanced Healthcare Materials, EarlyView.Here, we present a novel 3D cell patterning and culture platform. The “Floor‐Ceiling‐Chip” (FC‐Chip) consists of two opposing track‐etched membranes, creating a pseudo‐3D microenvironment for the cells in between. By providing the membranes with micropatterned cell‐adhesive islands of varying geometries and sizes, the FC‐Chip enables control over cell ...
Urandelger Tuvshindorj +10 more
wiley +1 more source
Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review
Advanced Healthcare Materials, EarlyView.Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami +4 more
wiley +1 more source
Mechanical Signaling: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets
MedCommCell mechanics is a fundamental regulator of numerous cellular processes, orchestrating critical biological activities spanning from embryogenesis to senescence.
Yicen Long +5 more
doaj +1 more source
BioengineeringIn this review, we explore the intricate relationship between glucose metabolism and mechanotransduction pathways, with a specific focus on the role of the Hippo signaling pathway in chondrocyte pathophysiology.
Jacob Jahn +5 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.3D printed hybrid scaffolds combining bioactive silica–calcium chemistry with elastic polymers guide human bone stem cells to form bone. The scaffolds support cell survival, organization, and invasion while releasing osteogenic ions. Together, architecture and composition drive bone‐specific gene expression, extracellular matrix organization, and ...
David R. Sory +3 more
wiley +1 more source
Review: Mechanotransduction in ovarian cancer: Shearing into the unknown
APL Bioengineering, 2018 Ovarian cancer remains a deadly diagnosis with an 85% recurrence rate and a 5-year survival rate of only 46%. The poor outlook of this disease has improved little over the past 50 years owing to the lack of early
Caymen Novak, Eric Horst, Geeta Mehta
doaj +1 more source
Matrix mechanotransduction mediated by thrombospondin-1/integrin/YAP in the vascular remodeling
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance We propose a mechanism of matrix mechanotransduction initiated by thrombospondin-1 (Thbs1), connecting mechanical stimuli to Yes-associated protein (YAP) signaling during vascular remodeling.
Yoshito Yamashiro +9 more
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.A paracrine factor local gradient (PFLG)‐generating system enables microvessel penetration across 3D hepatocyte tissues. The resulting vascularized constructs recapitulate hepatic sinusoidal hepatocyte—endothelial contact architecture and enhance hepatic functions in vitro.
Yen‐Hsiang Huang +2 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Magnetic Ion Channel Activation (MICA) enables remote stimulation of mechanosensitive ion channels using functionalised magnetic nanoparticles, enhancing extracellular vesicle (EV) biogenesis is pre‐osteoblasts. MICA desrived EVs exhibit typical nano‐vesicular characteristics but display superior pro‐osteogeneic activity, promoting mesenchymal stem ...
Afeesh Rajan Unnithan +9 more
wiley +1 more source
A small scale cell culture system to analyze mechanobiology using reporter gene constructs and polyurethane dishes [PDF]
European Cells & Materials, 2010 Mechanical forces are translated into biochemical signals and contribute to cell differentiation and phenotype maintenance. Mesenchymal stem cells and their tissue-specific offspring, as osteoblasts and chondrocytes, cells of cardiovascular tissues and ...
W Wilke +14 more
doaj