Results 111 to 120 of about 36,721 (301)

Mechanotransduction by Hair Cells: Models, Molecules, and Mechanisms

, 2009
Mechanotransduction, the transformation of mechanical force into an electrical signal, allows living organisms to hear, register movement and gravity, detect touch, and sense changes in cell volume and shape.
Gillespie, Peter G., Müller, Ulrich
core   +1 more source

Functional Disorder at the Neural Interface: How Disordered Nanostructures Promote Proper Growth and Differentiation in In Vitro Neural Cultures

Advanced Science, EarlyView.
This work provides a practical guide for neuroengineers to design advanced neural interfaces, embracing and tailoring the concept of functional disorder. By bridging 2D and 3D in vitro models, this work highlights how non‐periodic, spatially heterogeneous, multiscale nanotopography can enable more physiologically relevant platforms for studying neural ...
F. Maita, E. Palmieri, I. Lucarini, L. Montaina, L. Maiolo   +4 more
wiley   +1 more source

Lung Mechanotransduction, the minuet of Biophysics (Part 2)

The dynamic processes associated with lung pathophysiology have always been explored from a traditionalist perspective. This review conceptualizes an amalgam of biological and biophysical concepts that aim to optimize the understanding of the ...
Yolanda López-Fernández, Alberto Medina, Aurio Fajardo-Campoverdi, Miguel Ibarra-Estrada, Alejandro González-Castro, Elena Ortega, Paulina Vivanco   +6 more
core   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Mechanotransduction pathways in bone pathobiology

, 2015
The skeleton is subject to dynamic changes throughout life and bone remodeling is essential for maintenance of bone functionality. The cell populations which predominantly participate in bone and cartilage remodeling, namely osteocytes, osteoblasts ...
Spyropoulou, Anastasia, Basdra, Karamesinis, Konstantinos, Efthimia K.   +3 more
core   +2 more sources

Mechanotransduction for therapeutic approaches: Cellular aging and rejuvenation

APL Bioengineering
Mechanotransduction regulates cytoskeletal remodeling, nuclear mechanics, and metabolic adaptation, which are central to cellular aging and rejuvenation.
Hye-Min Han, Su-Yeon Kim, Dong-Hwee Kim
doaj   +1 more source

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source

A Correlative SICM‐OPM Platform for Surface and Volumetric Imaging in Live Cells

Advanced Science, EarlyView.
A multifunctional correlative imaging platform integrating Scanning Ion Conductance Microscopy (SICM) with Oblique Plane Microscopy (OPM) enables simultaneous surface topography, mechanical mapping, and 3D volumetric fluorescence imaging in live cells.
Wenzhi Hong, Ziwei Zhang, Ao Li, Ting Sun, Yunzhao Wu, Devkee M. Vadukul, Dylan Jones, Bing Li, Fengjie Liu, Francesco A. Aprile, Yuri Korchev, Julia Gorelik, David Klenerman, Andrew Shevchuk   +13 more
wiley   +1 more source

Mechanotransduction for mesenchymal stem cells

, 2009
107 p.This project is focused on the study of mechanotransduction of Human mesenchymal stem cells (hMSC). A mechanotransduction device was custom made to stimulate mechanotransduction to stem cells by stretching, bending or shearing cultured materials ...
Wu, Shucheng.
core  

The mechanotransduction-immune axis in organ fibrosis: dual regulatory mechanisms and translational therapeutic perspectives

Frontiers in Immunology
Organ fibrosis represents a final common pathway of chronic tissue injury, characterized by persistent extracellular matrix (ECM) accumulation and progressive loss of organ function.
Chao Lei, Dongjie Wu, Houyan Zhang, Zhiya Yang, Bohao Huang, Jie Wang, Yanbo Li, Wenliang Lv   +7 more
doaj   +1 more source