Results 121 to 130 of about 40,337 (298)

Flexible Dielectric Acoustic Resonator Patch for Tissue Regeneration

Advanced Materials, EarlyView.
A flexible dielectric acoustic resonator patch enables MHz‐range ultrasound generation through resonance amplification without using piezoelectric materials. Conformal integration on a curved substrate allows efficient acoustic delivery to tissue‐mimicking environments.
Donyoung Kang, Byeongseok Ryu, Sujeong Ahn, Junhyub Kim, Myeonghun Jang, Jeong Ho Cho, Won‐Gun Koh, Hyungsuk Lee   +7 more
wiley   +1 more source

Mechanobiology of bone remodeling and fracture healing in the aged organism

Innovative Surgical Sciences, 2016
Bone can adapt to changing load demands by mechanically regulated bone remodeling. Osteocytes, osteoblasts, and mesenchymal stem cells are mechanosensitive and respond to mechanical signals through the activation of specific molecular signaling pathways.
Haffner-Luntzer Melanie, Liedert Astrid, Ignatius Anita   +2 more
doaj   +1 more source

The murine catecholamine methyltransferase mTOMT is essential for mechanotransduction by cochlear hair cells

eLife, 2017
Hair cells of the cochlea are mechanosensors for the perception of sound. Mutations in the LRTOMT gene, which encodes a protein with homology to the catecholamine methyltransferase COMT that is linked to schizophrenia, cause deafness.
Christopher L Cunningham, Zizhen Wu, Aria Jafari, Bo Zhao, Kat Schrode, Sarah Harkins-Perry, Amanda Lauer, Ulrich Müller   +7 more
doaj   +1 more source

Bottom‐Up Programming of Cell States in Cancer Organoids with Defined Synthetic Adhesion Cues

Advanced Materials, EarlyView.
A bottom‐up biomaterial platform is developed to program transcriptomic states in pancreatic cancer organoids by tuning adhesion cues within synthetic matrices. By combining a Design of Experiments framework with multiobjective optimization, matrix compositions are identified that enrich specific cellular programs like EMT.
Ali Nadernezhad, Verena J. Kast, Dagmar Pette, Franziska Baenke, Daniel E. Stange, Carsten Werner, Daniela Loessner   +6 more
wiley   +1 more source

Mechanotransduction in Development

, 2011
Biochemical patterning and morphogenetic movements coordinate the design of embryonic development. The molecular processes that pattern and closely control morphogenetic movements are today becoming well understood. Recent experimental evidence demonstrates that mechanical cues generated by morphogenesis activate mechanotransduction pathways, which in ...
openaire   +3 more sources

Cell Adhesion by Design: Engineering Tissue Culture Scaffolds With Adhesion Cues

Advanced Materials Interfaces, EarlyView.
ABSTRACT In scaffold‐based tissue engineering, the matrix should provide adequate adhesion cues for cell attachment, spreading, and function. Given the multitude of adhesion receptors and the diversity of scaffolds, there are many approaches to render scaffolds adhesive, even though they are not all equivalent.
Dalia Dranseike, Dhananjay V. Deshmukh, Mark W. Tibbitt, Céline Labouesse   +3 more
wiley   +1 more source

In vivo analysis of hybrid hydrogels containing dual growth factor combinations, and skeletal stem cells under mechanical stimulation for bone repair

Mechanobiology in Medicine
Bone tissue engineering requires a combination of materials, cells, growth factors and mechanical cues to recapitulate bone formation. In this study we evaluated hybrid hydrogels for minimally invasive bone formation by combining biomaterials with ...
David Gothard, Michael Rotherham, Emma L. Smith, Janos M. Kanczler, James Henstock, Julia A. Wells, Carol A. Roberts, Omar Qutachi, Heather Peto, Hassan Rashidi, Luis Rojo, Lisa J. White, Molly M. Stevens, Alicia J. El Haj, Felicity R.A.J. Rose, Richard O.C. Oreffo   +15 more
doaj   +1 more source

Gold Nanorods in Cardiac Millitissues: Assessing Mechanical and Contractile Dynamics in a Living Engineering Myocardium Model

Advanced Materials Technologies, EarlyView.
This study presents a novel platform for assessing the active mechanical behavior of living cardiac microbundles through localized nanoindentation, integrated with temperature regulation and dual‐camera imaging systems. The developed system enables quantitative evaluation of dynamic micromechanics in engineered cardiac tissues in vitro, offering ...
Lihua Lou, Lia Paolino, Alberto Sesena Rubfiaro, Jin He, Arvind Agarwal   +4 more
wiley   +1 more source

BLOC: Buildable and Linkable Organ on a Chip

Advanced Materials Technologies, EarlyView.
We developed a “Buildable and Linkable Organ on a Chip” (BLOC) that can construct diverse microphysiological systems (MPSs). The BLOC is standardized to the same size and has one of the functions of “Culture,” “Control,” or “Analysis.” Users can freely configure various MPSs, including developing perfusion, cytotoxicity analysis, and biochemical ...
Yusuke Kimura, Hiroki Hamaguchi, Kotaro Oyama, Tomoko G. Oyama, Atsushi Kimura, Yasuhiro Ohshima, Noriko S. Ishioka, Mitsumasa Taguchi   +7 more
wiley   +1 more source

Anoctamin-1 is a core component of a mechanosensory anion channel complex in C. elegans

Nature Communications
Mechanotransduction channels are widely expressed in both vertebrates and invertebrates, mediating various physiological processes such as touch, hearing and blood-pressure sensing.
Wenjuan Zou, Yuedan Fan, Jia Liu, Hankui Cheng, Huitao Hong, Umar Al-Sheikh, Shitian Li, Linhui Zhu, Rong Li, Longyuan He, Yi-Quan Tang, Guohua Zhao, Yongming Zhang, Feng Wang, Renya Zhan, Xiujue Zheng, Lijun Kang   +16 more
doaj   +1 more source