Results 141 to 150 of about 30,077 (213)

TRPV4-Dependent Epithelial Mechanoadaptation and Barrier Remodeling Mediate Sennoside-Induced Distal Colonic Motility. [PDF]

Int J Mol Sci
Hara Y, Kawashima R, Tamaki S, Maekawa T, Kawamura YI, Tsujimoto T, Kusano C, Ichikawa T.   +7 more
europepmc   +1 more source

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

Matrix Stiffness Drives Aggressive Phenotype in Tongue Squamous Cell Carcinoma via Mechanotransduction-Stromal Signalling. [PDF]

Int Dent J
Tiskratok W, Kyawsoewin M, Thuephut R, Ketkrathok K, Leerahakanch C, Chanwises P, Jitprasertwong P, Yamada M, Egusa H, Limraksasin P.   +9 more
europepmc   +1 more source

Artificial Intelligence for Identifying Tumor‐Reactive CD8+ T Cells: Biological Principles, Computational Advances, and Future Directions

Med Research, EarlyView.
This review details a three‐stage paradigm shift for tumor‐reactive CD8+ T‐cell identification: decoding transcriptomic states, deciphering clonal functional efficacy, and molecular‐level therapeutic TCR design. Addressing translational hurdles and generative AI “scientific blind spots”—such as missing catch bonds—we present a visionary roadmap.
Chao Yang, Yingying Sun, Yan Zhang, Yifen Shi, Zhiwen Shi   +4 more
wiley   +1 more source

Mechanotransduction and its impact on regenerative medicine in orthopedic rehabilitation (Review). [PDF]

Int J Mol Med
Wang B, Zeng X, Liu H, Li L, Lei T, Li Y, Fang Q, Cao Y, Dong B.   +8 more
europepmc   +1 more source

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

Medicinal Research Reviews, EarlyView.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu, Saurabh Upadhyay, Moustafa T. Gabr   +2 more
wiley   +1 more source

Diabetes‐Induced Dysregulation of Purinergic Signaling in the Bladder Mucosa: Accelerated ATP Hydrolysis and Impaired Adenosine Uptake Promote Underactive Bladder Phenotype

Neurourology and Urodynamics, EarlyView.
ABSTRACT Objective To explore molecular mechanisms underlying excessive extracellular adenosine (ADO) accumulation in the bladder lamina propria (LP) of mice with type 2 diabetes (T2D) induced by a high‐fat, high‐sucrose diet (HFHSD), conceivably leading to bladder underactivity.
Mahsa Borhani Peikani, Brian A. Perrino, Violeta N. Mutafova‐Yambolieva   +2 more
wiley   +1 more source

Exercise Alleviates Osteoporosis and Hyperglycemia in Type 1 Diabetes Mellitus Mice via Piezo1-Mediated Mechanotransduction. [PDF]

Biology (Basel)
Cao M, Pang F, Yu Y, Yu J, Ma S, Sun L, Fan X, Tang L.   +7 more
europepmc   +1 more source

Effect of video‐based game therapy on activation of scapular muscles in children with thoracic hyperkyphosis

PM&R, EarlyView.
Abstract Background Game‐based rehabilitation has been shown to support motor control and muscle activation in children; therefore, video‐based gaming may represent a promising rehabilitation approach for targeting scapular muscles. Objective To examine the effects of video‐based game therapy on scapular muscle activation, strength, and upper extremity
Kubra Kardes, Ayse Zengin Alpozgen, Turgut Akgul   +2 more
wiley   +1 more source

Sono-Mechanogenetics: Linking Ultrasound Physics With Cellular Mechanobiology. [PDF]

Adv Sci (Weinh)
Qu Y, Wei F, Yoon CW, Zhou Q, Wang Y.
europepmc   +1 more source