Results 41 to 50 of about 41,911 (157)

Signalling cascades in mechanotransduction: cell-matrix interactions and mechanical loading

, 2009
Mechanical loading of articular cartilage stimulates the metabolism of resident chondrocytes and induces the synthesis of molecules to maintain the integrity of the cartilage.
Ramage, L., Salter, D. M., Nuki, G.
core   +1 more source

High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain [PDF]

, 2007
Little is known about the molecular basis of somatosensory mechanotransduction in mammals. We screened a library of peptide toxins for effects on mechanically activated currents in cultured dorsal root ganglion neurons.
Abrahamsen, B, Robinson, M, Rugiero, F, Colless, B, Drew, LJ, Brust, A, Heinzmann, S, Lewis, RJ, Wood, JN, Gale, JE, Cesare, P, Bowden, S   +11 more
core  

Mechanotransduction in striated muscle via focal adhesion kinase [PDF]

, 2007
Contractile tissues demonstrate a pronounced capacity to remodel their composition in response to mechanical challenges. Descriptive evidence suggests the upstream involvement of the phosphotransfer enzyme FAK (focal adhesion kinase) in the molecular ...
M Flück, Desplanches, D, Durieux, AC, Flück, M, Flueck, M., D Freyssenet, Freyssenet, D., Freyssenet, D, A C Durieux, Durieux, A. C., D Desplanches, Freyssenet, O, Durieux, A C, Desplanches, D.   +13 more
core   +1 more source

Mechanism and application of feedback loops formed by mechanotransduction and histone modifications

Genes and Diseases
Mechanical stimulation is the key physical factor in cell environment. Mechanotransduction acts as a fundamental regulator of cell behavior, regulating cell proliferation, differentiation, apoptosis, and exhibiting specific signature alterations during ...
Han Sun, Yafang Gao, Xinyu Ma, Yizhou Deng, Lintao Bi, Lisha Li   +5 more
doaj   +1 more source

Matrix remodeling and mechanotransduction in in vitro chondrogenesis: Implications towards functional stem cell‐based cartilage tissue engineering

Engineering Reports, 2020
Stem cell‐based cartilage regeneration strategies take benefits from functional tissue engineering concepts that effectively exploit cells native mechanotransduction phenomenon for the development of in vitro cartilage constructs.
Nirmal S. Remya, Prabha D. Nair
doaj   +1 more source

Piezo is essential for amiloride-sensitive stretch-activated mechanotransduction in larval Drosophila dorsal bipolar dendritic sensory neurons.

, 2015
Stretch-activated afferent neurons, such as those of mammalian muscle spindles, are essential for proprioception and motor co-ordination, but the underlying mechanisms of mechanotransduction are poorly understood.
Bewick, Guy S, Jarman, Andrew P, Shenton, Fiona C, Suslak, Thomas J, Thompson, Karen J, Watson, Sonia, Armstrong, J Douglas   +6 more
core   +1 more source

Mechanotransduction pathways in bone pathobiology [PDF]

, 2015
The skeleton is subject to dynamic changes throughout life and bone remodeling is essential for maintenance of bone functionality. The cell populations which predominantly participate in bone and cartilage remodeling, namely osteocytes, osteoblasts ...
Spyropoulou, Anastasia, Basdra, Karamesinis, Konstantinos, Efthimia K.   +3 more
core   +3 more sources

Simulated impact trauma and osteoarthritis: the role of cell volume and mechanotransduction [PDF]

, 2013
Health and emotional benefits are linked to participation in exercise, however single-impact load (e.g. trauma) and altered joint loading can cause bone fracture(s) resulting in permanent cartilage damage and increased risk of osteoarthritis (OA).
Nedelcheva, Y.
core   +1 more source

Mechanotransduction by Hair Cells: Models, Molecules, and Mechanisms [PDF]

, 2009
Mechanotransduction, the transformation of mechanical force into an electrical signal, allows living organisms to hear, register movement and gravity, detect touch, and sense changes in cell volume and shape.
Gillespie, Peter G., Müller, Ulrich
core   +1 more source

Mechanical Signaling: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm
Cell mechanics is a fundamental regulator of numerous cellular processes, orchestrating critical biological activities spanning from embryogenesis to senescence.
Yicen Long, Peng Wang, Jiacheng Lei, Baihai Su, Qiang Wei, Xiaojing Liu   +5 more
doaj   +1 more source