Results 41 to 50 of about 40,337 (298)
Non-overlapping functions for Pyk2 and FAK in osteoblasts during fluid shear stress-induced mechanotransduction. [PDF]
PLoS ONE, 2011 Mechanotransduction, the process by which cells convert external mechanical stimuli such as fluid shear stress (FSS) into biochemical changes, plays a critical role in maintenance of the skeleton.
Suzanne R L Young +4 more
doaj +1 more source
Open Biology, 2021 How do cells process environmental cues to make decisions? This simple question is still generating much experimental and theoretical work, at the border of physics, chemistry and biology, with strong implications in medicine.
Pierre-Henri Puech, Pierre Bongrand
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The Mechanotransduction Signaling Pathways in the Regulation of Osteogenesis
International Journal of Molecular Sciences, 2023 Bones are constantly exposed to mechanical forces from both muscles and Earth’s gravity to maintain bone homeostasis by stimulating bone formation. Mechanotransduction transforms external mechanical signals such as force, fluid flow shear, and gravity ...
Zhaoshuo Liu +5 more
semanticscholar +1 more source
Mammalian somatosensory mechanotransduction [PDF]
Current Opinion in Neurobiology, 2009 In the mammalian somatosensory system, mechanosensitive neurons mediate the senses of touch and pain. Among sensory modalities, mechanosensation has been the most elusive with regard to the identification of transduction molecules. One factor that has hindered the identification of transduction molecules is the diversity of neurons; physiological ...
Makoto, Tsunozaki, Diana M, Bautista
openaire +2 more sources
Osteocyte Mechanotransduction in Orthodontic Tooth Movement
Current Osteoporosis Reports, 2023 Orthodontic tooth movement is characterized by periodontal tissue responses to mechanical loading, leading to clinically relevant functional adaptation of jaw bone.
Hadi Seddiqi +2 more
semanticscholar +1 more source
Integrins in mechanotransduction [PDF]
Current Opinion in Cell Biology, 2013 Forces acting on cells govern many important regulatory events during development, normal physiology, and disease processes. Integrin-mediated adhesions, which transmit forces between the extracellular matrix and the actin cytoskeleton, play a central role in transducing effects of forces to regulate cell functions.
Ross, Tyler D +6 more
openaire +3 more sources
Aging and Disease, 2023 Cells are constantly exposed to various mechanical environments; therefore, it is important that they are able to sense and adapt to changes. It is known that the cytoskeleton plays a critical role in mediating and generating extra- and intracellular ...
Danyuan Huang +7 more
semanticscholar +1 more source
Rapping about Mechanotransduction [PDF]
Developmental Cell, 2018 Mechanical cues can regulate cell proliferation and differentiation through the Hippo-YAP signaling network. Reporting in Nature, Meng et al. (2018) show that the Ras-related GTPase RAP2 connects extracellular matrix stiffness to Hippo pathway regulation, adding to our understanding of how mechanical cues are converted into changes in YAP activity.
Consuelo, Ibar, Kenneth D, Irvine
openaire +2 more sources
Mechanical loading of desmosomes depends on the magnitude and orientation of external stress
Nature Communications, 2018 Desmosomes are intercellular adhesion complexes that connect the intermediate filament cytoskeletons of neighboring cells but direct evidence for their load-bearing nature is lacking.
Andrew J. Price +5 more
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Metavinculin modulates force transduction in cell adhesion sites
Nature Communications, 2020 Muscle cells express an adhesion molecule called metavinculin, which has been associated with cardiomyopathies. Here, the authors employed molecular tension sensors to reveal that metavinculin expression modulates cell adhesion mechanics and they develop
Verena Kanoldt +8 more
doaj +1 more source