Results 21 to 30 of about 36,721 (301)

Integrins in Mechanotransduction [PDF]

Journal of Biological Chemistry, 2004
Mechanical forces are crucial to the regulation of cell and tissue morphology and function. At the cellular level, forces influence cytoskeletal organization, gene expression, proliferation, and survival. Integrin-mediated adhesions are intrinsically mechanosensitive and a large body of data implicates integrins in sensing mechanical forces.
Akira, Katsumi, A Wayne, Orr, Eleni, Tzima, Martin Alexander, Schwartz   +3 more
openaire   +2 more sources

Mechanisms of Mechanotransduction [PDF]

Developmental Cell, 2006
Essentially all organisms from bacteria to humans are mechanosensitive. Physical forces regulate a large array of physiological processes, and dysregulation of mechanical responses contributes to major human diseases. A survey of both specialized and widely expressed mechanosensitive systems suggests that physical forces provide a general means of ...
Orr, A. Wayne, Helmke, Brian P., Blackman, Brett R., Schwartz, Martin A.   +3 more
openaire   +3 more sources

Mechanotransduction Activity Facilitates Hair Cell Toxicity Caused by the Heavy Metal Cadmium

Frontiers in Cellular Neuroscience, 2020
Hair cells are sensitive to many insults including environmental toxins such as heavy metals. We show here that cadmium can consistently kill hair cells of the zebrafish lateral line.
Caleigh Schmid, Isabella Alampi, Jay Briggs, Kelly Tarcza, Tamara M. Stawicki   +4 more
doaj   +1 more source

Integrins in mechanotransduction [PDF]

Current Opinion in Cell Biology, 2013
Forces acting on cells govern many important regulatory events during development, normal physiology, and disease processes. Integrin-mediated adhesions, which transmit forces between the extracellular matrix and the actin cytoskeleton, play a central role in transducing effects of forces to regulate cell functions.
Ross, Tyler D, Coon, Brian BG, Yun, Sanguk, Baeyens, Nicolas, Tanaka, Keiichiro, Ouyang, Mingxing, Schwartz, Martin A   +6 more
openaire   +4 more sources

Mechanotransduction and the glycocalyx [PDF]

Journal of Internal Medicine, 2006
Abstract.Endothelial cells (ECs) line all blood vessel walls and are exposed to the mechanical forces of blood flow which modulate their function and play a role in vascular regulation, remodelling and disease. The principal mechanical forces sensed by ECs are the shear stress of flowing blood on their apical surface, and the circumferential stress ...
J M, Tarbell, M Y, Pahakis
openaire   +2 more sources

LINCing Nuclear Mechanobiology With Skeletal Muscle Mass and Function

Frontiers in Cell and Developmental Biology, 2021
Skeletal muscle demonstrates a high degree of adaptability in response to changes in mechanical input. The phenotypic transformation in response to mechanical cues includes changes in muscle mass and force generating capabilities, yet the molecular ...
Maria J. A. van Ingen, Tyler J. Kirby
doaj   +1 more source

TRPV4 Mechanotransduction in Fibrosis [PDF]

Cells, 2021
Fibrosis is an irreversible, debilitating condition marked by the excessive production of extracellular matrix and tissue scarring that eventually results in organ failure and disease. Differentiation of fibroblasts to hypersecretory myofibroblasts is the key event in fibrosis.
Ravi K. Adapala, Venkatesh Katari, Lakshminarayan Reddy Teegala, Sathwika Thodeti, Sailaja Paruchuri, Charles K. Thodeti   +5 more
openaire   +3 more sources

Revealing hidden information in osteoblast’s mechanotransduction through analysis of time patterns of critical events

BMC Bioinformatics, 2020
Background Mechanotransduction in bone cells plays a pivotal role in osteoblast differentiation and bone remodelling. Mechanotransduction provides the link between modulation of the extracellular matrix by mechanical load and intracellular activity.
Gianluca Ascolani, Timothy M. Skerry, Damien Lacroix, Enrico Dall’Ara, Aban Shuaib   +4 more
doaj   +1 more source

Mechanotransduction and fibrosis [PDF]

Journal of Biomechanics, 2014
Scarring and tissue fibrosis represent a significant source of morbidity in the United States. Despite considerable research focused on elucidating the mechanisms underlying cutaneous scar formation, effective clinical therapies are still in the early stages of development.
Dominik, Duscher, Zeshaan N, Maan, Victor W, Wong, Robert C, Rennert, Michael, Januszyk, Melanie, Rodrigues, Michael, Hu, Arnetha J, Whitmore, Alexander J, Whittam, Michael T, Longaker, Geoffrey C, Gurtner   +10 more
openaire   +2 more sources

Non-overlapping functions for Pyk2 and FAK in osteoblasts during fluid shear stress-induced mechanotransduction. [PDF]

PLoS ONE, 2011
Mechanotransduction, the process by which cells convert external mechanical stimuli such as fluid shear stress (FSS) into biochemical changes, plays a critical role in maintenance of the skeleton.
Suzanne R L Young, Julia M Hum, Eric Rodenberg, Charles H Turner, Fredrick M Pavalko   +4 more
doaj   +1 more source