Results 21 to 30 of about 40,337 (298)

The mechanotransduction-immune axis in organ fibrosis: dual regulatory mechanisms and translational therapeutic perspectives. [PDF]

Front Immunol
Organ fibrosis represents a final common pathway of chronic tissue injury, characterized by persistent extracellular matrix (ECM) accumulation and progressive loss of organ function.
Lei C, Wu D, Zhang H, Yang Z, Huang B, Wang J, Li Y, Lv W.   +7 more
europepmc   +2 more sources

Extracellular mechanotransduction [PDF]

Journal of General Physiology, 2022
We highlight the force-sensing function of extracellular matrix and present a complementary mechanotransduction paradigm.
Haller, Stephen J., Dudley, Andrew T.
openaire   +3 more sources

The Mechanotransduction Channel and Organic Cation Transporter Are Critical for Cisplatin Ototoxicity in Murine Hair Cells

Frontiers in Molecular Neuroscience, 2022
Cisplatin is one of the most widely used chemotherapeutic drugs across the world. However, the serious ototoxic effects, leading to permanent hair cell death and hearing loss, significantly limit the utility of cisplatin.
Jinan Li, Chang Liu, Samuel Kaefer, Mariam Youssef, Bo Zhao   +4 more
doaj   +1 more source

Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets

Signal Transduction and Targeted Therapy, 2023
Cellular mechanotransduction, a critical regulator of numerous biological processes, is the conversion from mechanical signals to biochemical signals regarding cell activities and metabolism.
Xingpeng Di, Xiao-shuai Gao, L. Peng, J. Ai, Xi Jin, Shiqian Qi, Hong Li, Kunjie Wang, D. Luo   +8 more
semanticscholar   +1 more source

Mechanotransduction and extracellular matrix homeostasis

Nature Reviews Molecular Cell Biology, 2014
Jay D Humphrey, Eric R Dufresne, Martin A Schwartz   +2 more
exaly   +2 more sources

The role of osteocytes-specific molecular mechanism in regulation of mechanotransduction – A systematic review

Journal of Orthopaedic Translation, 2021
Background: Osteocytes, composing over 90% of bone cells, are well known for their mechanosensing abilities. Aged osteocytes with impaired morphology and function are less efficient in mechanotransduction which will disrupt bone turnover leading to ...
Meng Chen Michelle Li, Simon Kwoon Ho Chow, Ronald Man Yeung Wong, Ling Qin, Wing Hoi Cheung   +4 more
doaj   +1 more source

Response to mechanical stress is mediated by the TRPA channel painless in the Drosophila heart. [PDF]

PLoS Genetics, 2010
Mechanotransduction modulates cellular functions as diverse as migration, proliferation, differentiation, and apoptosis. It is crucial for organ development and homeostasis and leads to pathologies when defective.
Sébastien Sénatore, Vatrapu Rami Reddy, Michel Sémériva, Laurent Perrin, Nathalie Lalevée   +4 more
doaj   +1 more source

A possible molecular mechanism for mechanotransduction at cellular focal adhesion complexes

Biophysical Reports, 2021
Mechanotransduction at focal adhesion complexes is key for various cellular events. Theoretical analyses were performed to predict a potential role of lipid membranes in modulating mechanotransduction at focal adhesions.
Jichul Kim
doaj   +1 more source

Static and Dynamic: Evolving Biomaterial Mechanical Properties to Control Cellular Mechanotransduction

Advancement of science, 2023
The extracellular matrix (ECM) is a highly dynamic system that constantly offers physical, biological, and chemical signals to embraced cells. Increasing evidence suggests that mechanical signals derived from the dynamic cellular microenvironment are ...
Wenyan Xie, Xi Wei, Heemin Kang, Hong Jiang, Zhiqin Chu, Yuan Lin, Yong Hou, Q. Wei   +7 more
semanticscholar   +1 more source

Mechanical properties of the brain: Focus on the essential role of Piezo1‐mediated mechanotransduction in the CNS

Brain and Behavior, 2023
Background The brain is a highly mechanosensitive organ, and changes in the mechanical properties of brain tissue influence many physiological and pathological processes.
Qingcui Zheng, Hailin Liu, Wen Yu, Yao Dong, Lanqian Zhou, Wenze Deng, Fuzhou Hua   +6 more
doaj   +1 more source