Results 21 to 30 of about 16,257 (211)

LRP6 downregulation promotes cardiomyocyte proliferation and heart regeneration [PDF]

Cell Research, 2020
The adult mammalian heart is thought to be a terminally differentiated organ given the postmitotic nature of cardiomyocytes. Consequently, the potential for cardiac repair through cardiomyocyte proliferation is extremely limited. Low-density lipoprotein receptor-related protein 6 (LRP6) is a Wnt co-receptor that is required for embryonic heart ...
Yahan, Wu, Liping, Zhou, Hongyu, Liu, Ran, Duan, Huixing, Zhou, Fulei, Zhang, Xiaoyu, He, Dongbo, Lu, Ke, Xiong, Maolin, Xiong, Jinzhu, Zhuang, Yi, Liu, Li, Li, Dandan, Liang, Yi-Han, Chen   +14 more
openaire   +2 more sources

Evidence against a human cell-specific role for LRP6 in anthrax toxin entry. [PDF]

PLoS ONE, 2008
The role of the cellular protein LRP6 in anthrax toxin entry is controversial. Previous studies showed that LRP6 was important for efficient intoxication of human M2182 prostate carcinoma cells but other studies performed with cells from gene-knockout ...
Patricia L Ryan, John A T Young
doaj   +1 more source

PTK7 modulates Wnt signaling activity via LRP6 [PDF]

Development, 2014
Protein tyrosine kinase 7 (PTK7) is a transmembrane protein expressed in the developing Xenopus neural plate. PTK7 regulates vertebrate planar cell polarity (PCP), controlling mesodermal and neural convergent-extension (CE) cell movements, neural crest migration and neural tube closure in vertebrate embryos. Besides CE phenotypes, we now show that PTK7
Naama, Bin-Nun, Hava, Lichtig, Anastasia, Malyarova, Michal, Levy, Sara, Elias, Dale, Frank   +5 more
openaire   +2 more sources

LRP5 and LRP6 in development and disease [PDF]

Trends in Endocrinology & Metabolism, 2013
Low-density lipoprotein-related receptors 5 and 6 (LRP5/6) are highly homologous proteins with key functions in canonical Wnt signaling. Alterations in the genes encoding these receptors or their interacting proteins are linked to human diseases, and as such they have been a major focus of drug development efforts to treat several human conditions ...
Danese M, Joiner, Jiyuan, Ke, Zhendong, Zhong, H Eric, Xu, Bart O, Williams   +4 more
openaire   +2 more sources

Upregulation of the Wnt co-receptor LRP6 promotes hepatocarcinogenesis and enhances cell invasion. [PDF]

PLoS ONE, 2012
BACKGROUND: Activation of the Wnt/β-catenin signaling pathway plays a crucial role in hepatocellular carcinoma (HCC). Low-density lipoprotein (LDL) receptor-related protein-6 (LRP6) is one of the co-receptors of the Wnt/β-catenin pathway and forms a ...
Edmund Kwok-Kwan Tung, Betty Yin-Chi Wong, Tai-On Yau, Irene Oi-Lin Ng   +3 more
doaj   +1 more source

The Relationship between LRP6 and Wnt/β-Catenin Pathway in Colorectal and Esophageal Cancer

Life, 2023
High expression of low-density lipoprotein receptor-related protein 6 (LRP6), a key component of the Wnt/β-catenin signaling pathway, is reported to be associated with malignant potential in some solid tumors including breast cancer and hepatocellular ...
Akemi Shishido, Masaaki Miyo, Kazuki Oishi, Natsumi Nishiyama, Meiqiao Wu, Hiroyuki Yamamoto, Shihori Kouda, Xin Wu, Satoshi Shibata, Yuhki Yokoyama, Hirofumi Yamamoto   +10 more
doaj   +1 more source

R-spondin1 Is a High Affinity Ligand for LRP6 and Induces LRP6 Phosphorylation and β-Catenin Signaling [PDF]

Journal of Biological Chemistry, 2007
R-spondin proteins are newly identified secreted molecules that activate beta-catenin signaling. However, the mechanism of R-spondin action and its relationship with Wnt signaling remain unclear. Here we show that human R-spondin1 (hRspo1) is a high affinity ligand for the Wnt co-receptor LRP6 (K(d) = 1.2 nm).
Qiou, Wei, Chika, Yokota, Mikhail V, Semenov, Brad, Doble, Jim, Woodgett, Xi, He   +5 more
openaire   +2 more sources

Unveiling the Roles of Low-Density Lipoprotein Receptor-Related Protein 6 in Intestinal Homeostasis, Regeneration and Oncogenesis

Cells, 2021
Intestinal epithelial self-renewal is tightly regulated by signaling pathways controlling stem cell proliferation, determination and differentiation. In particular, Wnt/β-catenin signaling controls intestinal crypt cell division, survival and maintenance
Jennifer Raisch, Anthony Côté-Biron, Marie-Josée Langlois, Caroline Leblanc, Nathalie Rivard   +4 more
doaj   +1 more source

Investigation of a Novel LRP6 Variant Causing Autosomal-Dominant Tooth Agenesis

Frontiers in Genetics, 2021
BackgroundThe low-density lipoprotein receptor-related protein 6 (LRP6) gene is a recently defined gene that is associated with the autosomal-dominant inherited tooth agenesis (TA).
Yan-xia Huang, Chun-yan Gao, Chun-yan Zheng, Xu Chen, You-sheng Yan, Yong-qing Sun, Xing-yue Dong, Kai Yang, Dong-liang Zhang   +8 more
doaj   +1 more source

Upregulated wnt-11 and mir-21 expression trigger epithelial mesenchymal transition in aggressive prostate cancer cells [PDF]

, 2020
Prostate cancer (PCa) is the second-leading cause of cancer-related death among men. microRNAs have been identified as having potential roles in tumorigenesis.
Arisan, E.D., Arisan, E.D., Freitas, I.L., Freitas, I.L., Keskin, B., Keskin, B., Kothari, A., Kothari, A., Radzali, S., Radzali, S., Rencuzogullari, O., Rencuzogullari, O., Uysal-Onganer, P., Uysal-Onganer, P., Warford, A., Warford, A.   +15 more
core   +1 more source