Results 21 to 30 of about 183,541 (259)
Insight into the WNT system and its drug related response
Reumatismo, 2013 The WNT signalling pathway is a complex system for transferring information for DNA expression from the cell surface receptors to cytoplasm and then to the nucleus.
S. Tamanini +5 more
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Role of morphogenic proteins of the WNT signaling pathway in coronary artery disease
Медицинская иммунология, 2023 In recent years, researchers’ attention has been directed to the WNT signaling pathway study, which regulates embryogenesis processes and is involved in pathological condition development.
I. A. Snimshchikova, M. O. Plotnikova
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Evaluating the Role of Wnt Signal Transduction in Promoting the Development of the Heart
The Scientific World Journal, 2007 Wnts are a family of secreted signaling proteins that are encoded by 19 distinct genes in the vertebrate genome. These molecules initiate several signal transduction pathways: the canonical Wnt, Wnt/Ca2+, and Wnt/planar cell polarity pathways.
Leonard M. Eisenberg, Carol A. Eisenberg
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The vacuolar-ATPase inhibitor bafilomycin and mutant VPS35 inhibit canonical Wnt signaling
Neurobiology of Disease, 2007 Endosomal acidification and transport are essential functions in signal transduction. Recent data suggest that Wnt signaling requires intact endosomal transport machinery but the effects of endosomal acidification on Wnt signal transduction have not been
Ana George +3 more
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Monounsaturated Fatty Acid Modification of Wnt Protein: Its Role in Wnt Secretion [PDF]
Developmental Cell, 2006 The secretion and extracellular transport of Wnt protein are thought to be well-regulated processes. Wnt is known to be acylated with palmitic acid at a conserved cysteine residue (Cys77 in murine Wnt-3a), and this residue appears to be required for the control of extracellular transport. Here, we show that murine Wnt-3a is also acylated at a conserved
Takada, Ritsuko +7 more
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Use of a molecular genetic platform technology to produce human Wnt proteins reveals distinct local and distal signaling abilities. [PDF]
PLoS ONE, 2013 Functional and mechanistic studies of Wnt signaling have been severely hindered by the inaccessibility of bioactive proteins. To overcome this long-standing barrier, we engineered and characterized a panel of Chinese hamster ovary (CHO) cell lines with ...
Jennifer L Green +6 more
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A Protein Disulfide Isomerase Controls Neuronal Migration through Regulation of Wnt Secretion
Cell Reports, 2019 Summary: Appropriate Wnt morphogen secretion is required to control animal development and homeostasis. Although correct Wnt globular structure is essential for secretion, proteins that directly mediate Wnt folding and maturation remain uncharacterized ...
Nanna Torpe +6 more
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Wnt induces FZD5/8 endocytosis and degradation and the involvement of RSPO-ZNRF3/RNF43 and DVL
eLifeFrizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway. However, whether Wnt ligands induce FZD endocytosis and degradation remains elusive.
Dong Luo +6 more
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Frontiers in Pharmacology, 2021 The Wnt/β-catenin signaling pathway plays important roles in embryonic development and tissue homeostasis. Wnt signaling is induced, and β-catenin is activated, associated with the development and progression of renal fibrosis. Wnt/β-catenin controls the
Shan-Shan Li +8 more
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CellsUpon engagement of one of the nineteen secreted Wnt signaling proteins with one of the ten Frizzled transmembrane Wnt receptors (FZD1–10), a wide variety of cellular Wnt signaling responses can be elicited, the selectivity of which depends on the ...
Janine Wesslowski +4 more
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