Results 11 to 20 of about 1,874,468 (294)
Positive cooperativity in synergistic activation of Wnt proteins. [PDF]
Mol Biol RepAbstract Background Wnt proteins are crucial for embryonic development, stem cell growth, and tissue regeneration. Wnt signaling pathway is activated when Wnt proteins bind to cell membrane receptors. Methods and results We employed a luciferase reporter assay in HEK293STF
Bonnet C, Han CS, Deng SX, Zheng JJ.
europepmc +7 more sources
Soluble Frizzled-related proteins promote exosome-mediated Wnt re-secretion
Communications BiologyWnt proteins are thought to be transported in several ways in the extracellular space. For instance, they are known to be carried by exosomes and by Wnt-carrier proteins, such as sFRP proteins.
Thi Hong Nguyen Tran +6 more
doaj +2 more sources
Bioinformatic Analysis of WNT Family Proteins
Bioinformatics and Biology InsightsWNT proteins constitute a highly conserved family of signaling molecules that play an important role in regulating embryonic development and maintaining adult tissue homeostasis.
Konstantin Midlovets +2 more
doaj +3 more sources
Wnt Proteins in Mammary Development and Cancer
Journal of Mammary Gland Biology and Neoplasia, 2004 Secreted proteins of the Wnt family play widespread roles in the regulation of embryonic development, and aberrant activation of the canonical Wnt/beta-catenin pathway is one of the most frequent signaling abnormalities known in human cancer. While the consequences of Wnt signaling in development are diverse at the cellular level, they are often ...
Brennan, Keith R., Brown, Anthony M C
openaire +4 more sources
Cold Spring Harb Perspect Biol, 2012 Wnt proteins comprise a major family of signaling molecules that orchestrate and influence a myriad of cell biological and developmental processes. Although our understanding of the role of Wnt signaling in regulating development and affecting disease, such as cancer, has been ever increasing, the study of the Wnt proteins themselves has been ...
Willert K, Nusse R.
europepmc +4 more sources
The role of Evi/Wntless in exporting Wnt proteins.
Development, 2023 ABSTRACTIntercellular communication by Wnt proteins governs many essential processes during development, tissue homeostasis and disease in all metazoans. Many context-dependent effects are initiated in the Wnt-producing cells and depend on the export of lipidated Wnt proteins.
Wolf L, Boutros M.
europepmc +3 more sources
Process for producing active Wnt proteins in prokaryotes
, 2005 This invention provides a process for producing active Wnt proteins in a bacterial host. The process comprises that a nucleic acid sequence encoding a Wnt protein is expressed in a bacterial host in an oxidative environment in the cytoplasm of a redox ...
Vainio, Seppo +4 more
core +6 more sources
Wnt proteins as modulators of synaptic plasticity.
Curr Opin Neurobiol, 2018 Dynamic changes in the structure and function of synapses in response to the environment, termed synaptic plasticity, are the cellular basis of learning and memory. At excitatory synapses, activation of NMDA receptors by glutamate leads to calcium influx triggering intracellular pathways that promote the trafficking of AMPA receptors to the post ...
McLeod F, Salinas PC.
europepmc +4 more sources
Reporter gene HEK 293 cells and WNT/Frizzled fusion proteins as tools to study WNT signaling pathways [PDF]
, 2011 WNT/Frizzled receptor (FZD) signaling pathways are pivotal for physiological and pathophysiological processes. In humans, the complexity of WNT/FZD signaling is based on 19 WNTs, 10 FZDs and at least two (co)receptors (LRP5/6) mediating supposably four ...
Marisa Karow, +17 more
core +1 more source
Dissecting the impact of Frizzled receptors in Wnt/beta-catenin signaling of human mesenchymal stem cells [PDF]
, 2012 Wnt/beta-catenin signaling is of fundamental importance in the regulation of self-renewal, migration/invasion, and differentiation of human mesenchymal stem cells (hMSCs).
Ruiz-Heinrich, Lourdes +18 more
core +1 more source