Results 11 to 20 of about 184,406 (260)

Wnt Signaling Translocates Lys48-Linked Polyubiquitinated Proteins to the Lysosomal Pathway

Cell Reports, 2015
Cellular proteins are degraded in either proteasomes or lysosomes depending on the types of ubiquitin chains that covalently modify them. It is not known whether the choice between these two pathways is physiologically regulated.
Hyunjoon Kim, Philipp Vick, Joshua Hedtke, Diego Ploper, Edward M. De Robertis   +4 more
doaj   +1 more source

Wnt signalling pathway parameters for mammalian cells. [PDF]

PLoS ONE, 2012
Wnt/β-catenin signalling regulates cell fate, survival, proliferation and differentiation at many stages of mammalian development and pathology. Mutations of two key proteins in the pathway, APC and β-catenin, have been implicated in a range of cancers ...
Chin Wee Tan, Bruce S Gardiner, Yumiko Hirokawa, Meredith J Layton, David W Smith, Antony W Burgess   +5 more
doaj   +1 more source

Canonical Wnt signaling induces focal adhesion and Integrin beta-1 endocytosis

iScience, 2022
Summary: During canonical Wnt signaling, the Wnt receptor complex is sequestered together with glycogen synthase kinase 3 (GSK3) and Axin inside late endosomes, known as multivesicular bodies (MVBs).
Nydia Tejeda-Muñoz, Marco Morselli, Yuki Moriyama, Pooja Sheladiya, Matteo Pellegrini, Edward M. De Robertis   +5 more
doaj   +1 more source

Functional role of the Frizzled linker domain in the Wnt signaling pathway

Communications Biology, 2022
The linker domain of Frizzled receptors has a varying effect on the functional levels of canonical and non-canonical Wnt signaling, with FZD chimeras influencing the binding of Wnt proteins and the recruitment of proteins regulating downstream signaling.
Seung-Bum Ko, Emiko Mihara, Yedarm Park, Kyeonghwan Roh, Chanhee Kang, Junichi Takagi, Injin Bang, Hee-Jung Choi   +7 more
doaj   +1 more source

Xenopus frizzled-4S, a splicing variant of Xfz4 is a context-dependent activator and inhibitor of Wnt/β-catenin signaling

Cell Communication and Signaling, 2005
Background Secreted Frizzled related proteins (SFRPs) are extracellular regulators of Wnt signaling. These proteins contain an N-terminal cysteine rich domain (CRD) highly similar to the CRDs of the Frizzled family of seven-transmembrane proteins that ...
Medina Araceli, Katoh Masaru, Swain Rajeeb, Steinbeisser Herbert   +3 more
doaj   +1 more source

Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. [PDF]

PLoS Biology, 2006
The Wnts comprise a large class of secreted proteins that control essential developmental processes such as embryonic patterning, cell growth, migration, and differentiation.
Amanda J Mikels, Roel Nusse
doaj   +1 more source

Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling.

PLoS ONE, 2009
BackgroundMutation of Wnt signal antagonists Apc or Axin activates beta-catenin signaling in many cancers including the majority of human colorectal adenocarcinomas.
Jianhui Guo, Tolga Cagatay, Guangjin Zhou, Chih-Chiang Chan, Shelby Blythe, Kaye Suyama, Li Zheng, Kaifeng Pan, Chiping Qian, Richard Hamelin, Stephen N Thibodeau, Peter S Klein, Keith A Wharton, Wanguo Liu   +13 more
doaj   +1 more source

Wnts in adult brain: from synaptic plasticity to cognitive deficiencies

Frontiers in Cellular Neuroscience, 2013
During development of the central nervous system the Wnt signaling pathway has been implicated in a wide spectrum of physiological processes, including neuronal connectivity and synapse formation.
Carolina A. Oliva, Jessica Y. Vargas, Nibaldo C. Inestrosa   +2 more
doaj   +1 more source

Insight into the WNT system and its drug related response

Reumatismo, 2013
The WNT signalling pathway is a complex system for transferring information for DNA expression from the cell surface receptors to cytoplasm and then to the nucleus.
S. Tamanini, L. Idolazzi, D. Gatti, O. Viapiana, A. Fassio, M. Rossini   +5 more
doaj   +1 more source

Role of morphogenic proteins of the WNT signaling pathway in coronary artery disease

Медицинская иммунология, 2023
In recent years, researchers’ attention has been directed to the WNT signaling pathway study, which regulates embryogenesis processes and is involved in pathological condition development.
I. A. Snimshchikova, M. O. Plotnikova
doaj   +1 more source