Results 11 to 20 of about 271,086 (305)
Notum deacylates Wnt proteins to suppress signalling activity [PDF]
Nature, 2015 Signalling by Wnt proteins is finely balanced to ensure normal development and tissue homeostasis while avoiding diseases such as cancer. This is achieved in part by Notum, a highly conserved secreted feedback antagonist. Notum has been thought to act as a phospholipase, shedding glypicans and associated Wnt proteins from the cell surface.
Kakugawa, S +11 more
openaire +6 more sources
Bioinformatic Analysis of WNT Family Proteins
Bioinformatics and Biology InsightsWNT proteins constitute a highly conserved family of signaling molecules that play an important role in regulating embryonic development and maintaining adult tissue homeostasis.
Konstantin Midlovets +2 more
doaj +2 more sources
Cold Spring Harb Perspect Biol, 2012 Wnt proteins comprise a major family of signaling molecules that orchestrate and influence a myriad of cell biological and developmental processes. Although our understanding of the role of Wnt signaling in regulating development and affecting disease, such as cancer, has been ever increasing, the study of the Wnt proteins themselves has been ...
Willert K, Nusse R.
europepmc +4 more sources
ISX9 activates the Wnt/β-catenin signaling pathway and exerts neuroprotective effects in Alzheimer’s disease [PDF]
Alzheimer’s Research & TherapyBackground Defective Wnt/β-catenin signaling is closely associated with the pathogenesis of Alzheimer’s disease (AD), thus validating this pathway as a therapeutic target for AD. ISX9 is a potent agonist of the Wnt/β-catenin pathway.
Jianhong Xiao +9 more
doaj +2 more sources
Genome-wide identification and expression analysis of Wnt gene family in the forest musk deer (Moschus berezovskii) under musk secretion stage [PDF]
BMC GenomicsThe Wnt signaling pathway is ubiquitous in animals, playing a crucial role in embryonic development and adult tissue homeostasis in multicellular organisms.
Yu-JiaWei Gu +6 more
doaj +2 more sources
β-Arrestin interacts with the beta/gamma subunits of trimeric G-proteins and dishevelled in the Wnt/Ca(2+) pathway in xenopus gastrulation. [PDF]
PLoS ONE, 2014 β-Catenin independent, non-canonical Wnt signaling pathways play a major role in the regulation of morphogenetic movements in vertebrates. The term non-canonical Wnt signaling comprises multiple, intracellularly divergent, Wnt-activated and β-Catenin ...
Katharina Seitz +5 more
doaj +1 more source
The role of Sfrp and DKK proteins in cardiomyocyte development
Physiological Reports, 2021 In this review, we summarize the role of Wnt proteins in cardiomyogenesis. More specifically, we focus on how the development of cardiomyocytes from precursor cells involves a complex interplay between Wnt canonical β‐catenin signaling pathways and Wnt ...
Ying‐Chang Hsueh +2 more
doaj +1 more source
Wnt proteins as modulators of synaptic plasticity.
Curr Opin Neurobiol, 2018 Dynamic changes in the structure and function of synapses in response to the environment, termed synaptic plasticity, are the cellular basis of learning and memory. At excitatory synapses, activation of NMDA receptors by glutamate leads to calcium influx triggering intracellular pathways that promote the trafficking of AMPA receptors to the post ...
McLeod F, Salinas PC.
europepmc +5 more sources
Targets of Wnt/ß-catenin transcription in penile carcinoma. [PDF]
PLoS ONE, 2015 Penile squamous cell carcinoma (PeCa) is a rare malignancy and little is known regarding the molecular mechanisms involved in carcinogenesis of PeCa. The Wnt signaling pathway, with the transcription activator ß-catenin as a major transducer, is a key ...
Manit Arya +11 more
doaj +1 more source
Role of Wnt Signaling in Mouse Fetal Skin Wound Healing
Biomedicines, 2022 Wnt proteins secrete glycoproteins that are involved in various cellular processes to maintain homeostasis during development and adulthood. However, the expression and role of Wnt in wound healing have not been fully documented.
Kento Takaya +7 more
doaj +1 more source