Results 41 to 50 of about 1,874,468 (294)

Wnt induces FZD5/8 endocytosis and degradation and the involvement of RSPO-ZNRF3/RNF43 and DVL

eLife
Frizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway. However, whether Wnt ligands induce FZD endocytosis and degradation remains elusive.
Dong Luo, Jing Zheng, Shuning Lv, Ren Sheng, Maorong Chen, Xi He, Xinjun Zhang   +6 more
doaj   +1 more source

Targeting the Wnt/β-Catenin Signaling Pathway as a Potential Therapeutic Strategy in Renal Tubulointerstitial Fibrosis

Frontiers in Pharmacology, 2021
The Wnt/β-catenin signaling pathway plays important roles in embryonic development and tissue homeostasis. Wnt signaling is induced, and β-catenin is activated, associated with the development and progression of renal fibrosis. Wnt/β-catenin controls the
Shan-Shan Li, Shan-Shan Li, Qian Sun, Qian Sun, Meng-Ru Hua, Ping Suo, Jia-Rong Chen, Xiao-Yong Yu, Ying-Yong Zhao   +8 more
doaj   +1 more source

Differentiation of the brain vasculature : the answer came blowing by the Wnt [PDF]

, 2010
Vascularization of the vertebrate brain takes place during embryonic development from a preformed perineural vascular plexus. As a consequence of the intimate contact with neuroectodermal cells the vessels, which are entering the brain exclusively via ...
Liebner, Stefan, Plate, Karl, Stefan Liebner, Karl H Plate   +3 more
core   +1 more source

Quantification of Wnt3a, Wnt5a and Wnt16 Binding to Multiple Frizzleds Under Physiological Conditions Using NanoBit/BRET

Cells
Upon engagement of one of the nineteen secreted Wnt signaling proteins with one of the ten Frizzled transmembrane Wnt receptors (FZD1–10), a wide variety of cellular Wnt signaling responses can be elicited, the selectivity of which depends on the ...
Janine Wesslowski, Sadia Safi, Michelle Rottmann, Melanie Rothley, Gary Davidson   +4 more
doaj   +1 more source

Deletion of Porcn in mice leads to multiple developmental defects and models human focal dermal hypoplasia (Goltz syndrome). [PDF]

PLoS ONE, 2012
Focal Dermal Hypoplasia (FDH) is a genetic disorder characterized by developmental defects in skin, skeleton and ectodermal appendages. FDH is caused by dominant loss-of-function mutations in X-linked PORCN.
Wei Liu, Timothy M Shaver, Alfred Balasa, M Cecilia Ljungberg, Xiaoling Wang, Shu Wen, Hoang Nguyen, Ignatia B Van den Veyver   +7 more
doaj   +1 more source

Monounsaturated Fatty Acid Modification of Wnt Protein: Its Role in Wnt Secretion [PDF]

Developmental Cell, 2006
The secretion and extracellular transport of Wnt protein are thought to be well-regulated processes. Wnt is known to be acylated with palmitic acid at a conserved cysteine residue (Cys77 in murine Wnt-3a), and this residue appears to be required for the control of extracellular transport. Here, we show that murine Wnt-3a is also acylated at a conserved
Takada, Ritsuko, Satomi, Yoshinori, Kurata, Tomoko, Ueno, Naoto, Norioka, Shigemi, Kondoh, Hisato, Takao, Toshifumi, Takada, Shinji   +7 more
openaire   +2 more sources

The Meckel-Gruber syndrome protein TMEM67 controls basal body positioning and epithelial branching morphogenesis in mice via the non-canonical Wnt pathway. [PDF]

, 2015
Ciliopathies are a group of developmental disorders that manifest with multi-organ anomalies. Mutations in TMEM67 (MKS3) cause a range of human ciliopathies, including Meckel-Gruber and Joubert syndromes.
Daniel J. Jagger, Zakia A. Abdelhamed, Johnson, CA, Carmel Toomes, Jagger, DJ, Johnson, Colin A., Toomes, C, Wheway, G, Christopher F. Inglehearn, Colin A. Johnson, Jagger, Daniel J., Toomes, Carmel, Abdelhamed, ZA, Abdelhamed, Zakia A., Subaashini Natarajan, Inglehearn, CF, Natarajan, Subaashini, Gabrielle Wheway, Inglehearn, Christopher F., Natarajan, S, Inglehearn, Chris F., Wheway, Gabrielle   +21 more
core   +1 more source

Genome-wide identification and expression profiling analysis of Wnt family genes affecting adipocyte differentiation in cattle

Scientific Reports, 2022
The Wnt family features conserved glycoproteins that play roles in tissue regeneration, animal development and cell proliferation and differentiation. For its functional diversity and importance, this family has been studied in several species, but not ...
Cuili Pan, Shuzhe Wang, Chaoyun Yang, Chunli Hu, Hui Sheng, Xiaoshu Xue, Honghong Hu, Zhaoxiong Lei, Mengli Yang, Yun Ma   +9 more
doaj   +1 more source

Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression [PDF]

, 2012
Endothelial Wnt/β-catenin signaling is necessary for angiogenesis of the central nervous system and blood–brain barrier (BBB) differentiation, but its relevance for glioma vascularization is unknown. In this study, we show that doxycycline-dependent Wnt1
Devraj, Kavi, Nicole Ziegler, Fruttiger, Marcus, Rosario Heck, Sascha Seidel, Sonja Thom, Taketo, Makoto Mark, Kavi Devraj, Seidel, Sascha, Karl H. Plate, Liebner, Stefan, Reis, Marco, Bockamp, Ernesto, Heck, Rosario, Ernesto Bockamp, Marco Reis, Cathrin J. Czupalla, Makoto M. Taketo, Thom, Sonja, Zinke, Jenny, Plate, Karl, Macas, Jadranka, Jenny Zinke, Czupalla, Cathrin Jacqueline, Jadranka Macas, Stefan Liebner, Stefanie Dimmeler, Dimmeler, Stefanie, Ziegler, Nicole, Marcus Fruttiger   +29 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source