Results 41 to 50 of about 271,086 (305)

Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination. [PDF]

, 2011
Permanent damage to white matter tracts, comprising axons and myelinating oligodendrocytes, is an important component of brain injuries of the newborn that cause cerebral palsy and cognitive disabilities, as well as multiple sclerosis in adults. However,
Baranzini, Sergio E, Bruce, Charlotte C, Fancy, Stephen PJ, Franklin, Robin JM, Harrington, Emily P, Huang, Eric J, Nusse, Roel, Otero, Jose J, Rowitch, David H, Silbereis, John C, Yuen, Tracy J, Zhao, Chao   +11 more
core   +3 more sources

Evaluating the Role of Wnt Signal Transduction in Promoting the Development of the Heart

The Scientific World Journal, 2007
Wnts are a family of secreted signaling proteins that are encoded by 19 distinct genes in the vertebrate genome. These molecules initiate several signal transduction pathways: the canonical Wnt, Wnt/Ca2+, and Wnt/planar cell polarity pathways.
Leonard M. Eisenberg, Carol A. Eisenberg
doaj   +1 more source

The vacuolar-ATPase inhibitor bafilomycin and mutant VPS35 inhibit canonical Wnt signaling

Neurobiology of Disease, 2007
Endosomal acidification and transport are essential functions in signal transduction. Recent data suggest that Wnt signaling requires intact endosomal transport machinery but the effects of endosomal acidification on Wnt signal transduction have not been
Ana George, Hannah Leahy, Jianhua Zhou, Peter J. Morin   +3 more
doaj   +1 more source

Novel role for the innate immune receptor toll-like receptor 4 (TLR4) in the regulation of the wnt signaling pathway and photoreceptor apoptosis [PDF]

, 2012
Recent evidence has implicated innate immunity in regulating neuronal survival in the brain during stroke and other neurodegenerations. Photoreceptors are specialized light-detecting neurons in the retina that are essential for vision.
A Poltorak, A Wenzel, Abigail S. Hackam, AK Silva, AL Kindzelskii, Amit K. Patel, AO Edwards, AS Hackam, B Marsh, BJ Marsh, BJ Marsh, C Bowes, C Liu, C Niehrs, C Zhang, Chhinder P. Sodhi, CP Sodhi, CY Logan, D Jiang, David J. Hackam, DJ Kaczorowski, E Cario, E Chaum, E Okun, F Hua, F Limana, G Faraco, G Tezel, GA Limb, GM Seigel, GR Barile, GS Hageman, GT Higgins, H Yi, H Yi, HL Rosenzweig, HL Rosenzweig, HP Scholl, Hyun Yi, IA El-Ghrably, J Merenmies, J Qiu, J Watson, JK Shen, JR Caso, K Hoshino, K Kaarniranta, K Miyake, K Takeda, KP Mollen, L Barandon, L Minghetti, M Mizukami, MA Fragoso, Mauricio Martins Rodrigues, MD Gordon, MK Ko, MT Lotze, N Arimura, P Matzinger, PJ Franco, PY Leung, Q Xing, R Gauthier, R Gorina, R Kacimi, R Seitz, R Shechter, RM Vabulas, RR Caspi, RT Moon, S Lehnardt, S Lin, S Tell, S Walter, S Zareparsi, SC Gribar, SC Tang, SC Tang, SR Coats, T Ha, T Harada, T Harada, T Nakazawa, U Kilic, V Bocchini, V Fontaine, Y de Kozak, Y Xin, Z Tu   +89 more
core   +5 more sources

Use of a molecular genetic platform technology to produce human Wnt proteins reveals distinct local and distal signaling abilities. [PDF]

PLoS ONE, 2013
Functional and mechanistic studies of Wnt signaling have been severely hindered by the inaccessibility of bioactive proteins. To overcome this long-standing barrier, we engineered and characterized a panel of Chinese hamster ovary (CHO) cell lines with ...
Jennifer L Green, Matthieu Bauer, Kyu Won Yum, Yao-Cheng Li, Miranda L Cox, Karl Willert, Geoffrey M Wahl   +6 more
doaj   +1 more source

Could an endoneurial endothelial crosstalk between Wnt/β-catenin and Sonic Hedgehog pathways underlie the early disruption of the infra-orbital blood-nerve barrier following chronic constriction injury? [PDF]

, 2017
BackgroundBlood–nerve barrier disruption is pivotal in the development of neuroinflammation, peripheral sensitization, and neuropathic pain after peripheral nerve injury.
Boucher, Yves, Couraud, Pierre-Olivier, Mauborgne, Annie, Moreau, Nathan, Pohl, Michel, Romero, Ignacio A, Villanueva, Luis, Weksler, Babette B   +7 more
core   +4 more sources

Targeted protein degradation systems to enhance Wnt signaling

eLife, 2023
Abstract Molecules that facilitate targeted protein degradation (TPD) offer great promise as novel therapeutics. Human hepatic lectin, asialoglycoprotein receptor (ASGR) is selectively expressed on hepatocytes. We have previously engineered an anti-ASGR1 antibody-mutant RSPO2 (RSPO2RA) fusion protein (called SWEETSTM) to drive tissue ...
Heekyung Jung, Parthasarathy Sampathkumar, Hui Chen, Zhengjian Zhang, Nicholas Suen, Yiran Yang, Zhong Huang, Tom Lopez, Robert Benisch, Sung-Jin Lee, Jay Ye, Wen-Chen Yeh, Yang Li   +12 more
openaire   +3 more sources

Biochemical characterization of Wnt-Frizzled interactions using a soluble, biologically active vertebrate Wnt protein [PDF]

Proceedings of the National Academy of Sciences, 1999
Biochemical studies of Wnt signaling have been hampered by difficulties in obtaining large quantities of soluble, biologically active Wnt proteins. In this paper, we report the production in Drosophila S2 cells of biologically active Xenopus Wnt8 (XWnt8).
J C, Hsieh, A, Rattner, P M, Smallwood, J, Nathans   +3 more
openaire   +2 more sources

Hipk proteins dually regulate Wnt/Wingless signal transduction [PDF]

Fly, 2012
The Wnt/Wingless (Wg) pathway is an evolutionarily conserved signaling system that is used reiteratively, both spatially and temporally, to control the development of multicellular animals. The stability of cytoplasmic β-catenin/Armadillo, the transcriptional effector of the pathway, is controlled by sequential N-terminal phosphorylation and ...
Esther M, Verheyen, Sharan, Swarup, Wendy, Lee   +2 more
openaire   +2 more sources

Spreading around a Wnt protein [PDF]

Journal of Cell Biology, 2013
![Figure][1] In a fly lacking Trol, arrows and arrowheads mark the extra boutons in a neuromuscular junction stained for pre- (purple) and postsynaptic (green) markers. Aproteoglycan helps disperse Wnt proteins during development of the neuromuscular junction, [Kamimura et al.][2 ...
openaire   +1 more source