Results 31 to 40 of about 1,874,468 (294)

Role of morphogenic proteins of the WNT signaling pathway in coronary artery disease

Медицинская иммунология, 2023
In recent years, researchers’ attention has been directed to the WNT signaling pathway study, which regulates embryogenesis processes and is involved in pathological condition development.
I. A. Snimshchikova, M. O. Plotnikova
doaj   +1 more source

Differences in the secretion and transport of Wnt proteins [PDF]

Journal of Biochemistry, 2017
During the last three decades, our understanding about Wnt signaling has progressed greatly, especially with regards to the molecular mechanism of intracellular transmission of this signaling, as well as its physiological roles. In parallel, the molecular nature of Wnt proteins has gradually but surely been clarified.
Shinji, Takada, Sayumi, Fujimori, Takuma, Shinozuka, Ritsuko, Takada, Yusuke, Mii   +4 more
openaire   +2 more sources

A novel bidirectional positive feedback loop between Wnt/ -catenin and EGFR/ERK: role of context-specific signalling crosstalk in modulating epithelial tissue regeneration [PDF]

, 2014
By operating as both a subunit of the cadherin complex and a key component of Wnt signalling, β-catenin constitutes the lynchpin between cell:cell contact and transcriptional regulation of proliferation to co-ordinate epithelial tissue homeostasis and ...
Kirkwood, Lisa A., Southgate, Jennifer, Georgopoulos, Nikolaos T.   +2 more
core   +3 more sources

Evaluating the Role of Wnt Signal Transduction in Promoting the Development of the Heart

The Scientific World Journal, 2007
Wnts are a family of secreted signaling proteins that are encoded by 19 distinct genes in the vertebrate genome. These molecules initiate several signal transduction pathways: the canonical Wnt, Wnt/Ca2+, and Wnt/planar cell polarity pathways.
Leonard M. Eisenberg, Carol A. Eisenberg
doaj   +1 more source

WNT signalling in joint repair and homeostasis [PDF]

, 2011
PhDDisruption of the Wnt canonical signalling leads to the development of osteoarthritis both in human and in mice but the underlying molecular mechanisms are poorly understood.
Nalesso, Giovanna
core   +2 more sources

Wnt/beta-catenin/Tcf signaling: A critical pathway in gastrointestinal tumorigenesis [PDF]

, 2002
Cancers of the gastrointestinal tract, including the liver, bile ducts, and pancreas, constitute the largest group of malignant tumors. Colorectal cancer is one of the most common neoplastic diseases in Western countries and one of the leading causes of ...
Bommer, G., Göke, Burkhard, Göke, B., Kolligs, Frank T, Bommer, Guido, Kolligs, F. T.   +5 more
core   +1 more source

The vacuolar-ATPase inhibitor bafilomycin and mutant VPS35 inhibit canonical Wnt signaling

Neurobiology of Disease, 2007
Endosomal acidification and transport are essential functions in signal transduction. Recent data suggest that Wnt signaling requires intact endosomal transport machinery but the effects of endosomal acidification on Wnt signal transduction have not been
Ana George, Hannah Leahy, Jianhua Zhou, Peter J. Morin   +3 more
doaj   +1 more source

Use of a molecular genetic platform technology to produce human Wnt proteins reveals distinct local and distal signaling abilities. [PDF]

PLoS ONE, 2013
Functional and mechanistic studies of Wnt signaling have been severely hindered by the inaccessibility of bioactive proteins. To overcome this long-standing barrier, we engineered and characterized a panel of Chinese hamster ovary (CHO) cell lines with ...
Jennifer L Green, Matthieu Bauer, Kyu Won Yum, Yao-Cheng Li, Miranda L Cox, Karl Willert, Geoffrey M Wahl   +6 more
doaj   +1 more source

Wnt activation of immortalized brain endothelial cells as a tool for generating a standardized model of the blood brain barrier in vitro [PDF]

, 2013
Reproducing the characteristics and the functional responses of the blood–brain barrier (BBB) in vitro represents an important task for the research community, and would be a critical biotechnological breakthrough.
Eleanna Papa (441409), Rudini, Noemi, B. Engelhardt, Papa, Eleanna, E. Papa, M. Corada, Kavi Devraj, Pierre Olivier Couraud (383879), Couraud, Pierre Olivier, Luca Ferrarini, Monica Corada, Roberta Paolinelli, Pierre Olivier Couraud, K. Devraj, Luigi Maddaluno (441408), Cathrin J Czupalla, Engelhardt, Britta, Britta Engelhardt, Stefan Liebner (307398), R. Paolinelli, Noemi Rudini (441407), C. J. Czupalla, Cédric Artus, Luca Ferrarini (441403), E. Dejana, Elisabetta Dejana, C. Artus, Roberta Paolinelli (237864), Ferrarini, Luca, Devraj, Kavi, Dejana, Elisabetta, N. Rudini, Elisabetta Dejana (110746), Paolinelli, Roberta, Liebner, Stefan, Noemi Rudini, Monica Corada (217515), Cathrin J. Czupalla (441406), Kavi Devraj (441404), Artus, Cédric, Luigi Maddaluno, Cédric Artus (441405), Eleanna Papa, P. O. Couraud, Corada, Monica, Czupalla, Cathrin Jacqueline, Stefan Liebner, L. Maddaluno, Czupalla, Cathrin J., S. Liebner, Maddaluno, Luigi, Britta Engelhardt (307404), L. Ferrarini, Maddaluno Luigi, Devraj Kavi, Paolinelli Roberta, Liebner Stefan, Ferrarini Luca, Dejana Elisabetta, Papa Eleanna, Couraud Pierre Olivier, Rudini Noemi, Corada Monica, Artus Cédric, Czupalla Cathrin J., Engelhardt Britta   +65 more
core   +3 more sources

A phenotypic screen in zebrafish identifies a novel small-molecule inducer of ectopic tail formation suggestive of alterations in non-canonical Wnt/PCP signaling [PDF]

, 2013
Zebrafish have recently emerged as an attractive model for the in vivo bioassay-guided isolation and characterization of pharmacologically active small molecules of natural origin.
Alexander D. Crawford, Crawford, Alexander D, Alexander I. Gray, Cordero-Maldonado, María Lorena, de Witte, Peter A M, Gray, Alexander I, Alan L Harvey, Camila V. Esguerra, Gebruers, Evelien, Evelien Gebruers, Harvey, Alan L, Carol Clements, Clements, Carol, Alexander D Crawford, Edrada-Ebel, Ruangelie, Camila V Esguerra, Alan L. Harvey, Ruangelie Edrada-Ebel, Esguerra, Camila V, María Lorena Cordero-Maldonado, Alexander I Gray, Peter A M de Witte, Cordero Maldonado, María Lorena, Peter A. M. de Witte, Edrada-Ebel, R., CRAWFORD, Alexander Dettmar, De Witte, P. A. M., Crawford Alexander D., Clements Carol, de Witte Peter A. M., Cordero-Maldonado, M. L., Gebruers, E., Edrada-Ebel Ruangelie, Esguerra, C. V., Cordero-Maldonado María Lorena, Gray Alexander I., Clements, C., Gebruers Evelien, Harvey, A. L., Esguerra Camila V., Gray, A. I., Harvey Alan L.   +41 more
core   +3 more sources