Results 31 to 40 of about 183,541 (259)

Deletion of Porcn in mice leads to multiple developmental defects and models human focal dermal hypoplasia (Goltz syndrome). [PDF]

PLoS ONE, 2012
Focal Dermal Hypoplasia (FDH) is a genetic disorder characterized by developmental defects in skin, skeleton and ectodermal appendages. FDH is caused by dominant loss-of-function mutations in X-linked PORCN.
Wei Liu, Timothy M Shaver, Alfred Balasa, M Cecilia Ljungberg, Xiaoling Wang, Shu Wen, Hoang Nguyen, Ignatia B Van den Veyver   +7 more
doaj   +1 more source

Chimeric Wnt proteins define the amino-terminus of Wnt-1 as a transformation-specific determinant [PDF]

Oncogene, 1999
Wnt-1 induces morphological transformation of C57MG mammary epithelial cells and accumulation of cytosolic beta-catenin whereas Wnt-5a has no effect. To identify regions within the 370 amino acid Wnt-1 protein required for these functions we tested eleven chimeric genes that contained variable amounts of Wnt-1 and Wnt-5a sequence.
M A, Julius, S D, Rai, J, Kitajewski
openaire   +2 more sources

Genome-wide identification and expression profiling analysis of Wnt family genes affecting adipocyte differentiation in cattle

Scientific Reports, 2022
The Wnt family features conserved glycoproteins that play roles in tissue regeneration, animal development and cell proliferation and differentiation. For its functional diversity and importance, this family has been studied in several species, but not ...
Cuili Pan, Shuzhe Wang, Chaoyun Yang, Chunli Hu, Hui Sheng, Xiaoshu Xue, Honghong Hu, Zhaoxiong Lei, Mengli Yang, Yun Ma   +9 more
doaj   +1 more source

Pharmacological interventions in the Wnt pathway: inhibition of Wnt secretion versus disrupting the protein–protein interfaces of nuclear factors [PDF]

British Journal of Pharmacology, 2017
Mutations in components of the Wnt pathways are a frequent cause of many human diseases, particularly cancer. Despite the fact that a causative link between aberrant Wnt signalling and many types of human cancers was established more than a decade ago, no Wnt signalling inhibitors have made it into the clinic so far.
Zimmerli, Dario, Hausmann, George, Cantù, Claudio, Basler, Konrad   +3 more
openaire   +4 more sources

The amyloid precursor protein is a conserved Wnt receptor

eLife, 2021
The Amyloid Precursor Protein (APP) and its homologues are transmembrane proteins required for various aspects of neuronal development and activity, whose molecular function is unknown. Specifically, it is unclear whether APP acts as a receptor, and if so what its ligand(s) may be.
Liu, Tengyuan, Zhang, Tingting, Nicolas, Maya, Boussicault, Lydie, Rice, Heather, Soldano, Alessia, Claeys, Annelies, Petrova, Iveta, Fradkin, Lee, De Strooper, Bart, Potier, Marie-Claude, Hassan, Bassem A.   +11 more
openaire   +5 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

HDAC1 regulates inflammation and osteogenic differentiation of ankylosing spondylitis fibroblasts through the Wnt-Smad signaling pathway

Journal of Orthopaedic Surgery and Research, 2022
Ankylosing spondylitis (AS) is a refractory autoimmune disease, whose typical pathology is the development of inflammation to ossification and ankylosis.
Yong Zeng, Rui He, Yong Liu, Ting Luo, Qing Li, Yu He, Miao Fang, Taiping Wang   +7 more
doaj   +1 more source

LRP5 and LRP6 in Wnt Signaling: Similarity and Divergence

Frontiers in Cell and Developmental Biology, 2021
The canonical Wnt/β-catenin signaling plays a fundamental role in regulating embryonic development, injury repair and the pathogenesis of human diseases.
Qian Ren, Jiongcheng Chen, Youhua Liu, Youhua Liu   +3 more
doaj   +1 more source

A Role for WNT Proteins in Induction of Dermomyotome

Developmental Biology, 1997
Dorsoventral patterning of somites into sclerotome and dermomyotome involves antagonistic actions of ventralizing and dorsalizing signals originating from tissues surrounding the somites. The notochord and the floor plate of the neural tube provide a ventralizing signal(s) directing sclerotome development, whereas the surface ectoderm and dorsal neural
Fan, Chen-Ming, Lee, Catherine S., Tessier-Lavigne, Marc   +2 more
openaire   +2 more sources

Roles of Wnt proteins in neural development and maintenance [PDF]

Current Opinion in Neurobiology, 2000
Many constituents of Wnt signaling pathways are expressed in the developing and mature nervous systems. Recent work has shown that Wnt signaling controls initial formation of the neural plate and many subsequent patterning decisions in the embryonic nervous system, including formation of the neural crest.
A, Patapoutian, L F, Reichardt
openaire   +2 more sources