Results 31 to 40 of about 239,096 (264)

Disinhibition of the HECT E3 ubiquitin ligase WWP2 by polymerized Dishevelled [PDF]

Open Biology, 2015
Dishevelled is a pivot in Wnt signal transduction, controlling both β-catenin-dependent transcription to specify proliferative cell fates, and cell polarity and other non-nuclear events in post-mitotic cells.
Thomas Mund, Michael Graeb, Juliusz Mieszczanek, Melissa Gammons, Hugh R. B. Pelham, Mariann Bienz   +5 more
doaj   +1 more source

Morphogenesis and axis specification occur in parallel during optic cup and optic fissure formation, differentially modulated by BMP and Wnt [PDF]

Open Biology, 2019
Optic cup morphogenesis is an intricate process. Especially, the formation of the optic fissure is not well understood. Persisting optic fissures, termed coloboma, are frequent causes for congenital blindness.
Priska Eckert, Max D. Knickmeyer, Lucas Schütz, Joachim Wittbrodt, Stephan Heermann   +4 more
doaj   +1 more source

Canonical WNT pathway inhibition reduces ATP synthesis rates in glioblastoma stem cells

Frontiers in Bioscience-Landmark, 2022
Background: The conserved stem cell signaling network canonical Wingless (WNT) plays important roles in development and disease. Aberrant activation of this pathway has been linked to tumor progression and resistance to therapy.
Dymphna Margriet Ouwens, Michael Hewera, Guanzhang Li, Wang Di, Sajjad Muhammad, Daniel Hänggi, Hans-Jakob Steiger, Claudia A. Dumitru, Erol Sandalcioglu, Roland S Croner, Wei Zhang, Or Kakhlon, Ulf D. Kahlert   +12 more
doaj   +1 more source

Arf6 is necessary for senseless expression in response to wingless signalling during Drosophila wing development

Biology Open, 2021
Wnt signalling is a core pathway involved in a wide range of developmental processes throughout the metazoa. In vitro studies have suggested that the small GTP binding protein Arf6 regulates upstream steps of Wnt transduction, by promoting the ...
Julien Marcetteau, Tamàs Matusek, Frédéric Luton, Pascal P. Thérond   +3 more
doaj   +1 more source

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

Stimulation of epidermal hyperplasia and tumorigenesis by resident p16INK4a-expressing cells

Molecular & Cellular Oncology, 2020
p16INK4a (CDKN2A) is a central tumor-suppressor and activator of senescence. We recently found that prolonged expression of p16INK4a in epidermal cells induces hyperplasia and dysplasia through Wnt-mediated stimulation of neighboring keratinocytes.
Narmen Azazmeh, Ittai Ben-Porath
doaj   +1 more source

Wnt-1 and Wnt-4 regulate thymic cellularity [PDF]

European Journal of Immunology, 2002
Thymic primordium, formed by cells derived from the endoderm, the ectoderm and the neural crest-derived mesenchyme, receive fetal liver derived lymphoid precursors. Reciprocal cell-cell interactions between thymic stromal cells and lymphoid precursors are critical in the expansion and maturation of thymocytes. Transcription factor TCF-1 is critical for
Mulroy, Thomas, McMahon, Jill A., Burakoff, Steven J., McMahon, Andrew P., Sen, Jyoti   +4 more
openaire   +2 more sources

Nephrogenic Rests/Nephroblastomatosis in Patients With Unilateral Wilms Tumor Are Not Associated With an Increased Risk of Relapse: An Analysis of Patients Treated on the SIOP‐WT‐2001 Protocol in the SIOP‐UK‐CCLG and SIOP‐GPOH Studies (2001–2022)

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Nephrogenic rests (NRs) and nephroblastomatosis (NBM) are precursor lesions for development of Wilms tumor (WT). Their association with the risk of relapse has not been properly assessed, partly due to misunderstanding of their diagnostic criteria and terminology.
Gordan M. Vujanić, Rhoikos Furtwängler, Tanzina Chowdhury, Christian Vokuhl, Jenny Wegert, Norbert Graf   +5 more
wiley   +1 more source

Transcription Factor FOSL1 Promotes Cisplatin Resistance in Non-Small Cell Lung Cancer Cells by Modulating the Wnt3a/β-Catenin Signaling through Upregulation of PLIN3 Expression

Frontiers in Bioscience-Landmark
Background: Lung adenocarcinoma (LUAD) is the most prevalent histological subtype of lung cancer, accounting for 45.3% of all cases and serving as a major cause of cancer-related mortality.
Wanning Tong, Jianjun Sun, Bin Shen, Yaohua Hu, Chenxing Wang, Min Rao, Jin Li, Delin Xia, Jiagui Dong, Hong Wang, Dongmei Zhu, Haibo Wu, Zhigang Cai   +12 more
doaj   +1 more source

Mechanism of inhibition of growth and metastasis of colon cancer by celecoxib analog OSU-03013 via wnt signaling pathway [PDF]

Acta Poloniae Pharmaceutica
OSU-03013 is a structurally modified analog of celecoxib. This study probed the antitumor activity of OSU-03013 on colon cancer (CC) and explored its possible mechanism.
ChunYong Yang, ZhiQiang Zhou, XueSong Wang, JianZhe Ren, Jing Qi   +4 more
doaj   +1 more source