Results 21 to 30 of about 313,995 (297)
Wnt and Wnt inhibitors in bone metastasis [PDF]
BoneKEy Reports, 2012 Bone metastasis is a clinically devastating development of progressive cancers including prostate carcinoma, breast carcinoma and multiple myeloma. Bone metastases are typically painful, lead to adverse skeletal-related events, such as fracture, and are highly resistant to therapy.
Joseph L, Sottnik +3 more
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SLC20a1/PiT-1 is required for chorioallantoic placental morphogenesis
Vascular Biology, 2023 The placenta mediates the transport of nutrients, such as inorganic phosphate (Pi), between the maternal and fetal circulatory systems. The placenta itself also requires high levels of nutrient uptake as it develops to provide critical support for fetal ...
Ana Correia-Branco +10 more
doaj +1 more source
Cold Spring Harbor Perspectives in Biology, 2012 Wnt proteins comprise a major family of signaling molecules that orchestrate and influence a myriad of cell biological and developmental processes. Although our understanding of the role of Wnt signaling in regulating development and affecting disease, such as cancer, has been ever increasing, the study of the Wnt proteins themselves has been ...
Karl, Willert, Roel, Nusse
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Shiyan dongwu yu bijiao yixue, 2021 ObjectiveTo explore whether CD137-CD137L signaling can promote cardio-cerebral angiogenesis in atherosclerotic plaques via endothelium-mesenchymal transition (End-MT).MethodsMouse brain-derived endothelial cells (Bend.3) and aortas from male mice were ...
WENG Jiayi +3 more
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Frontiers in Physiology, 2019 Studies support that regular physical activity (PA) decelerates senescence-related decline of physiological and molecular parameters in the elderly. We have addressed the other end of this spectrum: healthy and young, inactive individuals participated in
Kitti Garai +15 more
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Quantitative analysis of signaling responses during mouse primordial germ cell specification
Biology Open, 2021 During early mammalian development, the pluripotent cells of the embryo are exposed to a combination of signals that drive exit from pluripotency and germ layer differentiation.
Sophie M. Morgani +1 more
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Developmental Cell, 2003 A recent Juan March Foundation workshop on "wnt genes and Wnt signaling" brought developmental and cancer biologists together to share some of the latest advances in Wnt research. Discussion topics included molecular, genetic, and genomic dissections of wnt genes in embryogenesis and cancer, Wnt signaling components and downstream targets, interactions
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miR-7 Controls the Dopaminergic/Oligodendroglial Fate through Wnt/β-catenin Signaling Regulation
Cells, 2020 During the development of the central nervous system, the proliferation of neural progenitors and differentiation of neurons and glia are tightly regulated by different transcription factors and signaling cascades, such as the Wnt and Shh pathways.
Lavanya Adusumilli +12 more
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Reporter gene HEK 293 cells and WNT/Frizzled fusion proteins as tools to study WNT signaling pathways [PDF]
, 2011 WNT/Frizzled receptor (FZD) signaling pathways are pivotal for physiological and pathophysiological processes. In humans, the complexity of WNT/FZD signaling is based on 19 WNTs, 10 FZDs and at least two (co)receptors (LRP5/6) mediating supposably four ...
Marisa Karow, +17 more
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Cartilage development and degeneration: a Wnt Wnt situation [PDF]
Cell Biochemistry and Function, 2012 The Wnt signaling pathway plays a crucial role in the development and homeostasis of a variety of adult tissues and, as such, is emerging as an important therapeutic target for numerous diseases. Factors involved in the Wnt pathway are expressed throughout limb development and chondrogenesis and have been shown to be critical in joint homeostasis and ...
Katherine Ann, Staines +2 more
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