Results 11 to 20 of about 239,096 (264)
SLC20a1/PiT-1 is required for chorioallantoic placental morphogenesis
Vascular Biology, 2023 The placenta mediates the transport of nutrients, such as inorganic phosphate (Pi), between the maternal and fetal circulatory systems. The placenta itself also requires high levels of nutrient uptake as it develops to provide critical support for fetal ...
Ana Correia-Branco +10 more
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Shiyan dongwu yu bijiao yixue, 2021 ObjectiveTo explore whether CD137-CD137L signaling can promote cardio-cerebral angiogenesis in atherosclerotic plaques via endothelium-mesenchymal transition (End-MT).MethodsMouse brain-derived endothelial cells (Bend.3) and aortas from male mice were ...
WENG Jiayi +3 more
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Cold Spring Harbor Perspectives in Biology, 2012 Wnt proteins comprise a major family of signaling molecules that orchestrate and influence a myriad of cell biological and developmental processes. Although our understanding of the role of Wnt signaling in regulating development and affecting disease, such as cancer, has been ever increasing, the study of the Wnt proteins themselves has been ...
Karl, Willert, Roel, Nusse
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Frontiers in Physiology, 2019 Studies support that regular physical activity (PA) decelerates senescence-related decline of physiological and molecular parameters in the elderly. We have addressed the other end of this spectrum: healthy and young, inactive individuals participated in
Kitti Garai +15 more
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Quantitative analysis of signaling responses during mouse primordial germ cell specification
Biology Open, 2021 During early mammalian development, the pluripotent cells of the embryo are exposed to a combination of signals that drive exit from pluripotency and germ layer differentiation.
Sophie M. Morgani +1 more
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Developmental Cell, 2003 A recent Juan March Foundation workshop on "wnt genes and Wnt signaling" brought developmental and cancer biologists together to share some of the latest advances in Wnt research. Discussion topics included molecular, genetic, and genomic dissections of wnt genes in embryogenesis and cancer, Wnt signaling components and downstream targets, interactions
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miR-7 Controls the Dopaminergic/Oligodendroglial Fate through Wnt/β-catenin Signaling Regulation
Cells, 2020 During the development of the central nervous system, the proliferation of neural progenitors and differentiation of neurons and glia are tightly regulated by different transcription factors and signaling cascades, such as the Wnt and Shh pathways.
Lavanya Adusumilli +12 more
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To Wnt or not to Wnt: the bone and joint health dilemma [PDF]
Nature Reviews Rheumatology, 2013 The Wnt signalling cascades have essential roles in development, growth and homeostasis of joints and the skeleton. Progress in basic research, particularly relating to our understanding of intracellular signalling cascades and fine regulation of receptor activation in the extracellular space, has provided novel insights into the roles of Wnt ...
Lories, Rik J. +2 more
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eLife, 2016 Many organisms lose the capacity to regenerate damaged tissues as they mature. Damaged Drosophila imaginal discs regenerate efficiently early in the third larval instar (L3) but progressively lose this ability.
Robin E Harris +3 more
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Winning WNT: Race to Wnt signaling inhibitors [PDF]
Proceedings of the National Academy of Sciences, 2011 More than a quarter of a century ago, a mammalian homolog of Drosophila wingless, int-1 (Wnt1), was identified as an oncogenic viral integration site in mouse breast cancer (1). A decade later, deregulation of canonical Wnt/β-catenin signaling through mutations in adenomatous polyposis coli (APC) was recognized to be an initiating event in colon ...
Kazuhide, Watanabe, Xing, Dai
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