Results 11 to 20 of about 305,854 (292)
Integration of SHH and WNT pathways controls morphogenesis of the CNS. [PDF]
, 2008 [eng] Dorsoventral patterning of the vertebrate nervous system is achieved by the combined activity of morphogenetic signals secreted from dorsal and ventral signalling centres. The Shh/Gli pathway plays a major role in patterning the ventral neural tube;
Álvarez Medina, José Roberto
core +6 more sources
WNT signalling in joint repair and homeostasis [PDF]
, 2011 PhDDisruption of the Wnt canonical signalling leads to the development of osteoarthritis both in human and in mice but the underlying molecular mechanisms are poorly understood.
Nalesso, Giovanna
core +4 more sources
When Wnts antagonize Wnts [PDF]
The Journal of Cell Biology, 2003 Secreted Wnt ligands appear to activate a variety of signaling pathways. Two papers in this issue now present genetic evidence that “noncanonical” Wnt signaling inhibits the “canonical” Wnt/β-catenin pathway. Westfall et al. (2003a) show that zebrafish embryos lacking maternal Wnt-5 function are dorsalized due to ectopic activation of β-catenin ...
Weidinger, Gilbert, Moon, Randall T.
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Activation of the Wnt Pathway by Mycobacterium tuberculosis: A Wnt–Wnt Situation [PDF]
Frontiers in Immunology, 2017 Mycobacterium tuberculosis (M. tuberculosis), an intracellular pathogenic Gram-positive bacterium, is the cause of Tuberculosis, a major worldwide human infectious disease. The innate immune system is the first host defense against M. tuberculosis. The recognition of this pathogen is mediated by several classes of pattern recognition receptors (PRRs ...
Tomás Villaseñor +5 more
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Wnt and Wnt inhibitors in bone metastasis [PDF]
BoneKEy Reports, 2012 Bone metastasis is a clinically devastating development of progressive cancers including prostate carcinoma, breast carcinoma and multiple myeloma. Bone metastases are typically painful, lead to adverse skeletal-related events, such as fracture, and are highly resistant to therapy.
Joseph L, Sottnik +3 more
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Cold Spring Harbor Perspectives in Biology, 2012 Wnt proteins comprise a major family of signaling molecules that orchestrate and influence a myriad of cell biological and developmental processes. Although our understanding of the role of Wnt signaling in regulating development and affecting disease, such as cancer, has been ever increasing, the study of the Wnt proteins themselves has been ...
Karl, Willert, Roel, Nusse
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Prostate cancer stem cell fate: β-catenin and the Wnt pathway [PDF]
, 2010 A major problem in prostate cancer is the high relapse rate post therapy. This is believed to be due to the presence of a small number of prostate cancer stem cells within a tumour.
Jakoby, Sarah
core +6 more sources
Developmental Cell, 2003 A recent Juan March Foundation workshop on "wnt genes and Wnt signaling" brought developmental and cancer biologists together to share some of the latest advances in Wnt research. Discussion topics included molecular, genetic, and genomic dissections of wnt genes in embryogenesis and cancer, Wnt signaling components and downstream targets, interactions
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Quantitative analysis of signaling responses during mouse primordial germ cell specification
Biology Open, 2021 During early mammalian development, the pluripotent cells of the embryo are exposed to a combination of signals that drive exit from pluripotency and germ layer differentiation.
Sophie M. Morgani +1 more
doaj +1 more source
Augmenting endogenous wnt signaling improves skin wound healing [PDF]
, 2013 Wnt signaling is required for both the development and homeostasis of the skin, yet its contribution to skin wound repair remains controversial. By employing Axin2(LacZ/+) reporter mice we evaluated the spatial and temporal distribution patterns of Wnt ...
Manzano Wilfred R. +57 more
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