Results 61 to 70 of about 75,163 (297)
Frontiers in Oncology, 2023 IntroductionCancer Stem Cells (CSC) are responsible for maintaining tumor growth, chemoresistance, and metastasis. Therefore, understanding their characteristics is critical to progress in cancer therapy.
Miguel Angel Sarabia-Sánchez +5 more
doaj +1 more source
Canonical Wnt Signaling Pathway on Polarity Formation of Utricle Hair Cells
Neural Plasticity, 2021 As part of the inner ear, the vestibular system is responsible for sense of balance, which consists of three semicircular canals, the utricle, and the saccule.
Di Deng +8 more
doaj +1 more source
Role of canonical Wnt signaling in endometrial carcinogenesis [PDF]
Expert Review of Anticancer Therapy, 2012 While the role of Wnt signaling is well established in colorectal carcinogenesis, its function in gynecologic cancers has not been elucidated. Here, we describe the current state of knowledge of canonical Wnt signaling in endometrial cancer (EC), and its implications for future therapeutic targets. Deregulation of the Wnt/β-catenin signaling pathway in
Dellinger, Thanh H +3 more
openaire +4 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Canonical and non-canonical Wnt pathways. [PDF]
, 2014 Scheme of the interactions observed between canonical and non-canonical Wnt pathways.
Agata Homa (468129) +13 more
core +1 more source
Membrane Targeting of Disheveled Can Bypass the Need for Arrow/LRP5
Scientific Reports, 2017 The highly conserved Wnt signaling pathway regulates cell proliferation and differentiation in vertebrates and invertebrates. Upon binding of a Wnt ligand to a receptor of the Fz family, Disheveled (Dsh/Dvl) transduces the signal during canonical and non-
Prameet Kaur +5 more
doaj +1 more source
A CRISPR knockout screen reveals new regulators of canonical Wnt signaling
Oncogenesis, 2021 The Wnt signaling pathways play fundamental roles during both development and adult homeostasis. Aberrant activation of the canonical Wnt signal transduction pathway is involved in many diseases including cancer, and is especially implicated in the ...
Tamar Evron +9 more
doaj +1 more source
Canonical WNT pathway inhibition reduces ATP synthesis rates in glioblastoma stem cells
Frontiers in Bioscience-Landmark, 2022 Background: The conserved stem cell signaling network canonical Wingless (WNT) plays important roles in development and disease. Aberrant activation of this pathway has been linked to tumor progression and resistance to therapy.
Dymphna Margriet Ouwens +12 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
WNT signalling in joint repair and homeostasis [PDF]
, 2011 PhDDisruption of the Wnt canonical signalling leads to the development of osteoarthritis both in human and in mice but the underlying molecular mechanisms are poorly understood.
Nalesso, Giovanna
core