Adenoid ameloblastoma harbors beta-catenin mutations [PDF]
Modern Pathology, 2022 Adenoid ameloblastoma is a very rare benign epithelial odontogenic tumor characterized microscopically by epithelium resembling conventional ameloblastoma, with additional duct-like structures, epithelial whorls, and cribriform architecture. Dentinoid deposits, clusters of clear cells, and ghost-cell keratinization may also be present.
Victor Coutinho Bastos +13 more
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A reappraisal of transcriptional regulation by NR5A1 and beta-catenin in adrenocortical carcinoma [PDF]
Frontiers in Endocrinology, 2023 BackgroundOverexpression of the transcription factor NR5A1 and constitutive activation of canonical Wnt signalling leading to nuclear translocation of beta-catenin are hallmarks of malignancy in adrenocortical carcinoma (ACC).
Enzo Lalli, Enzo Lalli, Enzo Lalli
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Beta-catenin expression in psoriasis
Indian Dermatology Online Journal, 2015 Psoriasis is a common inflammatory skin disease characterized by abnormal keratinocyte proliferation and differentiation. Beta-catenin participates in intercellular adhesion. Catenins are proteins found in complexes with cadherin cell adhesion molecules of cells. The role of catenin in regulating keratinocyte stem cell differentiation and hair follicle
Mohamed A Gaber +3 more
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Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing. [PDF]
PLoS Medicine, 2007 BACKGROUND: Delayed fracture healing causes substantial disability and usually requires additional surgical treatments. Pharmacologic management to improve fracture repair would substantially improve patient outcome.
Yan Chen +6 more
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Transcriptome analysis of beta-catenin-related genes in CD34+ haematopoietic stem and progenitor cells from patients with AML [PDF]
Mediterranean Journal of Hematology and Infectious DiseasesBackground: Acute myeloid leukaemia(AML) is a disease of the haematopoietic stem cells. Beta-catenin, a key element of the Wnt signalling, which is particularly active in various cancers.
Buket Altinok Gunes +10 more
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The Saudi Journal of Gastroenterology, 2013 Background/Aim: The inactivation of the tumor suppressor gene and activation of the proto-oncogene are key steps in the development of human cancer. p53 and beta-catenin are examples of such genes, respectively.
Mila Ghosh +3 more
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β-Catenin signaling increases during melanoma progression and promotes tumor cell survival and chemoresistance. [PDF]
PLoS ONE, 2011 Beta-catenin plays an important role in embryogenesis and carcinogenesis by controlling either cadherin-mediated cell adhesion or transcriptional activation of target gene expression.
Tobias Sinnberg +7 more
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GSK3beta is involved in JNK2-mediated beta-catenin inhibition. [PDF]
PLoS ONE, 2009 We have recently reported that mitogen-activated protein kinase (MAPK) JNK1 downregulates beta-catenin signaling and plays a critical role in regulating intestinal homeostasis and in suppressing tumor formation.
Dong Hu +4 more
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beta-Catenin regulates intercellular signalling networks and cell-type specific transcription in the developing mouse midbrain-rhombomere 1 region. [PDF]
PLoS ONE, 2010 beta-Catenin is a multifunctional protein involved in both signalling by secreted factors of Wnt family and regulation of the cellular architecture.
Dmitri Chilov +4 more
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CK1epsilon is required for breast cancers dependent on beta-catenin activity. [PDF]
PLoS ONE, 2010 Aberrant beta-catenin signaling plays a key role in several cancer types, notably colon, liver and breast cancer. However approaches to modulate beta-catenin activity for therapeutic purposes have proven elusive to date.To uncover genetic dependencies in
So Young Kim +13 more
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