NKX2-5 regulates the expression of beta-catenin and GATA4 in ventricular myocytes. [PDF]
PLoS ONE, 2009 The molecular pathway that controls cardiogenesis is temporally and spatially regulated by master transcriptional regulators such as NKX2-5, Isl1, MEF2C, GATA4, and beta-catenin.
Ali M Riazi +7 more
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Diagnostic Pathology, 2011 Background Beta-catenin, a component of the Wingless/Wnt signaling pathway, can activate target genes linking with the adenomatous polyposis coli (APC) gene in colorectal cancer.
Cheng Hongxia +3 more
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Quercetin treatment reduces the severity of renal dysplasia in a beta-catenin dependent manner.
PLoS ONE, 2020 Renal dysplasia, the major cause of childhood renal failure, is characterized by defective branching morphogenesis and nephrogenesis. Beta-catenin, a transcription factor and cell adhesion molecule, is markedly increased in the nucleus of kidney cells in
Joanna Cunanan +7 more
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Bioinformatics Knowledge Map for Analysis of Beta-Catenin Function in Cancer. [PDF]
PLoS ONE, 2015 Given the wealth of bioinformatics resources and the growing complexity of biological information, it is valuable to integrate data from disparate sources to gain insight into the role of genes/proteins in health and disease.
İrem Çelen +3 more
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WNT4/beta-catenin pathway maintains female germ cell survival by inhibiting activin betaB in the mouse fetal ovary. [PDF]
PLoS ONE, 2010 Female germ cells are essential for organogenesis of the ovary; without them, ovarian follicles do not form and functional and structural characteristics of the ovary are lost.
Chia-Feng Liu +2 more
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The Wnt/beta-catenin pathway interacts differentially with PTHrP signaling to control chondrocyte hypertrophy and final maturation. [PDF]
PLoS ONE, 2009 Sequential proliferation, hypertrophy and maturation of chondrocytes are required for proper endochondral bone development and tightly regulated by cell signaling.
Xizhi Guo +3 more
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Kinetics of Wnt-driven beta-catenin stabilization revealed by quantitative and temporal imaging.
PLoS ONE, 2008 The Wnt/beta-catenin signal transduction pathway regulates a broad range of developmental processes. Aberrant activation of the Wnt pathway leads to cancer and degenerative diseases.
Rami N Hannoush
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Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of the Wnt/beta-catenin pathway. [PDF]
PLoS ONE, 2009 BACKGROUND:Aberrant activation of Wnt/beta-catenin signaling promotes the development of several cancers. It has been demonstrated that the Wnt signaling pathway is activated in chronic lymphocytic leukemia (CLL) cells, and that uncontrolled Wnt/beta ...
Desheng Lu +8 more
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A nuclear function for armadillo/beta-catenin.
PLoS Biology, 2004 The Wnt signaling pathway provides key information during development of vertebrates and invertebrates, and mutations in this pathway lead to various forms of cancer.
Nicholas S Tolwinski, Eric Wieschaus
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Folia Histochemica et Cytobiologica, 2007 In progression of tumours, resulting from, i.e., release of cells from the parental tumour and development of metastases, expression of cell adhesion molecules (CAM) plays a significant role.
Marcin Nowak +2 more
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