Results 41 to 50 of about 674,582 (266)

Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy

Advanced Healthcare Materials, EarlyView.
This review summarizes the developmental basis of endochondral ossification (ECO) and its applications in bone tissue engineering (BTE). It first outlines the key biological processes and signaling pathways underlying ECO, then discusses biomaterial‐based engineering strategies derived from these principles, and finally highlights future directions for
Yiqi Su, Zihao He, Qianqian Chen, Long Chen, Caiyi Wei, Zijin Zhou, Jianhao Lin, Hui Li, Dan Xing   +8 more
wiley   +1 more source

Beta-catenin in the melanocyte lineage.

Pigment cell research, 2004
beta-Catenin is a multifunctional protein involved in cell-cell adhesion, intracellular signalling and gene transcription. It has been implicated in the development of various lineages, including neural crest derivatives. Melanocytes are derived from neural crest cells and beta-catenin is expressed throughout the development of this cell lineage.
Larue, L, Kumasaka, M, Goding, C
openaire   +2 more sources

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

Advanced Healthcare Materials, EarlyView.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang   +5 more
wiley   +1 more source

Beta-catenin expression and allelic loss at APC in sporadic colorectal carcinogenesis.

, 2002
beta-catenin is involved in E-cadherin-mediated cell adhesion, intracellular signal transduction, and also interacts with adenomatous polyposis coli (APC) protein.
Tomlinson, IP, Frayling, I.M., Hao, X, Han, W., Frayling, IM, Talbot, Ian C., Willcocks, T.C., Willocks, T., Hao, Xingpei, Tomlinson, Ian P., Pretlow, T.P., Pignatelli, M.N., Talbot, I.C., Frayling, Ian Martin, Han, W, Tomlinson, I.P.M., Pignatelli, Massimo N., Pignatelli, MN, Willcocks, TC, Han, Wei, Pretlow, Theresa P., Pretlow, TP, Hao, X., Willcocks, Teresa C., Talbot, IC   +24 more
core   +1 more source

Differential Regulation of Growth-Promoting Signalling Pathways by E-Cadherin [PDF]

, 2010
Background: Despite the well-documented association between loss of E-cadherin and carcinogenesis, as well as the link between restoration of its expression and suppression of proliferation in carcinoma cells, the ability of E-cadherin to modulate growth-
Dawn C Walker, Kirkwood, L.A., Lisa A Kirkwood, Dawn C. Walker, Georgopoulos, N.T., Lisa A. Kirkwood, Kirkwood Lisa A., Jennifer Southgate, Georgopoulos, Nikolaos T., Walker, Dawn C., Walker, D.C., Georgopoulos Nikolaos T., Nikolaos T. Georgopoulos, Kirkwood, Lisa A., Southgate, Jennifer, Southgate, J., Southgate Jennifer, Nikolaos T Georgopoulos, Walker Dawn C.   +18 more
core   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Hex acts with beta-catenin to regulate anteroposterior patterning via a Groucho-related co-repressor and Nodal [PDF]

, 2006
In Xenopus, the establishment of the anteroposterior axis involves two key signalling pathways, canonical Wnt and Nodal-related TGFbeta. There are also a number of transcription factors that feedback upon these pathways.
Gardner, Clare E, Clare E. Gardner, Geoffrey I. Johnston, Brickman, Joshua M, Andrea L. Zamparini, Tim Watts, Zamparini, Andrea L, Tomlinson, Simon R, Watts, Tim, Joshua M. Brickman, Johnston, Geoffrey I, Simon R. Tomlinson   +11 more
core   +1 more source

Emerging Direct Targeting β-Catenin Agents

, 2022
Aberrant accumulation of β-catenin in the cell nucleus as a result of deregulation of the Wnt/β-catenin pathway is found in various types of cancer.
Marianna Nalli, Masci, Domiziana, Silvestri, Romano, Domiziana Masci, Romano Silvestri, La Regina, Giuseppe, Giuseppe La Regina, Urbani, Andrea, Andrea Urbani, Nalli, Marianna   +9 more
core   +1 more source

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

An immunohistochemical study of beta-catenin in HNPCC colon tumours

, 2004
Includes bibliographical references (leaves 49-55).Beta-catenin is normally complexed with adenomatous polyposis coli (APC) protein and E-cadherin adhesion molecule, and localized on the cell membrane.
Watkins, Jennifer G
core