Results 31 to 40 of about 135,228 (293)
Wnt Signaling in Neural Crest Ontogenesis and Oncogenesis. [PDF]
, 2019 Neural crest (NC) cells are a temporary population of multipotent stem cells that generate a diverse array of cell types, including craniofacial bone and cartilage, smooth muscle cells, melanocytes, and peripheral neurons and glia during embryonic ...
Hao, Hongyan +4 more
core +2 more sources
Beta-Catenin in Pseudoexfoliation Syndrome [PDF]
Applied Sciences, 2020 To find whether it is possible that beta-catenin, associated with the development of serious systemic diseases, as well as the neoplastic process, plays a role in the development of pseudoexfoliation syndrome (PEX). If so, identifying PEX, an age-related, vision-threatening disorder of elastic fibers, which is manifested in eyes by the accumulation of ...
Joanna Stafiej +5 more
openaire +2 more sources
Regulation of slow and fast muscle myofibrillogenesis by Wnt/beta-catenin and myostatin signaling. [PDF]
PLoS ONE, 2009 Deviation from proper muscle development or homeostasis results in various myopathic conditions. Employing genetic as well as chemical intervention, we provide evidence that a tight regulation of Wnt/beta-catenin signaling is essential for muscle fiber ...
Jin-Ming Tee +3 more
doaj +1 more source
Functions of p120ctn in development and disease [PDF]
, 2012 p120 catenin (p120ctn), a component of the cadherin-catenin complex, was the first member to be identified in a most interesting subfamily of the Armadillo family. Several p120ctn isoforms are generated by alternative splicing.
Pieters, Tim +2 more
core +1 more source
Beta-catenin cleavage enhances transcriptional activation [PDF]
Scientific Reports, 2018 AbstractNuclear activation of Wnt/β-catenin signaling is required for cell proliferation in inflammation and cancer. Studies from our group indicate that β-catenin activation in colitis and colorectal cancer (CRC) correlates with increased nuclear levels of β-catenin phosphorylated at serine 552 (pβ-Cat552).
Tatiana Goretsky +12 more
openaire +3 more sources
eLife, 2019 Beta-catenin (i.e., canonical Wnt) signaling controls CNS angiogenesis and the blood-brain and blood-retina barriers. To explore the role of the Discs large/membrane-associated guanylate kinase (Dlg/MAGUK) family of scaffolding proteins in beta-catenin ...
Chris Cho +4 more
doaj +1 more source
Molecular and cellular pathogenesis of adamantinomatous craniopharyngioma. [PDF]
, 2015 Adamantinomatous craniopharyngiomas (ACPs) are the most common pituitary tumours in children. Although histologically benign, these are clinically aggressive tumours, difficult to manage and associated with poor quality of life for the patients.
Martinez-Barbera, JP
core +1 more source
Silencing mutated β-catenin inhibits cell proliferation and stimulates apoptosis in the adrenocortical cancer cell line H295R [PDF]
, 2013 Adrenocortical carcinoma (ACC) is a rare and highly aggressive endocrine neoplasm, with limited therapeutic options. Activating β-catenin somatic mutations are found in ACC and have been associated with a poor clinical outcome. In fact, activation of the
Bertherat, Jérôme +11 more
core +8 more sources
Functional Wnt signaling is increased in idiopathic pulmonary fibrosis. [PDF]
PLoS ONE, 2008 BackgroundIdiopathic pulmonary fibrosis (IPF) is a fatal lung disease, characterized by distorted lung architecture and loss of respiratory function.
Melanie Königshoff +6 more
doaj +1 more source
Increasing β-catenin/Wnt3A activity levels drive mechanical strain-induced cell cycle progression through mitosis. [PDF]
, 2016 Mechanical force and Wnt signaling activate β-catenin-mediated transcription to promote proliferation and tissue expansion. However, it is unknown whether mechanical force and Wnt signaling act independently or synergize to activate β-catenin signaling ...
Benham-Pyle, Blair W +4 more
core +2 more sources