Results 11 to 20 of about 674,582 (266)
p35/cdk5 binds and phosphorylates beta-catenin and regulates beta-catenin/presenilin-1 interaction
European Journal of Neuroscience, 2001 The neuronal cyclin-dependent kinase p35/cdk5 comprises a catalytic subunit (cdk5) and an activator subunit (p35). To identify novel p35/cdk5 substrates, we utilized the yeast two-hybrid system to screen for human p35 binding partners.
Brownlees, J +7 more
core +4 more sources
β-catenin takes a HIT [PDF]
Cell Cycle, 2008 Histidine triad (HIT) proteins represent a small family of nucleotide-binding and -hydrolyzing proteins, which attracted the attention of cancer biologists because their expression is lost in multiple human malignancies. To some of the family members including Fhit, Hint1 and Hint2, a tumor suppressive activity was assigned.
Otmar, Huber, Jörg, Weiske
openaire +2 more sources
MicroRNA roles in beta-catenin pathway [PDF]
Molecular Cancer, 2010 Abstractβ-catenin, a key factor in the Wnt signaling pathway, has essential functions in the regulation of cell growth and differentiation. Aberrant β-catenin signaling has been linked to various disease pathologies, including an important role in tumorigenesis.
Han Lei +6 more
openaire +3 more sources
In melanoma, beta-catenin is a suppressor of invasion [PDF]
Oncogene, 2011 Cell-type-specific signalling determines cell fate under physiological conditions, but it is increasingly apparent that also in cancer development the impact of any given oncogenic pathway on the individual cancer pathology is dependent on cell-lineage-specific molecular traits.
Arozarena, I +5 more
openaire +3 more sources
Nuclear beta-catenin in mesenchymal tumors [PDF]
Modern Pathology, 2005 Beta-catenin is a crucial part of the Wnt and E-cadherin signalling pathways, which are involved in tumorigenesis. Dysregulation of these pathways allow beta-catenin to accumulate and translocate to the nucleus, where it may activate oncogenes. Such nuclear accumulation can be detected by immunohistochemistry, which may be useful in diagnosis. Although
Tony L, Ng +8 more
openaire +2 more sources
Journal of Oral and Maxillofacial Pathology, 2016 In continuation with the previous review on "β-catenin in health", in this review we discuss the role of β-catenin in the pathogenesis of common oral lesions in the oral and maxillofacial region- oral potentially malignant disorders, their progression to oral squamous cell carcinoma, salivary gland tumors and odontogenic tumours.
Prakash, Sharada +3 more
openaire +3 more sources
Predominance of beta-catenin mutations and beta-catenin dysregulation in sporadic aggressive fibromatosis (desmoid tumor) [PDF]
Oncogene, 1999 Aggressive fibromatosis (also called desmoid tumor) occurs as a sporadic lesion or as part of Familial Adenomatous Polyposis, which is caused by germ line mutations in the Adenomatous polyposis Coli (APC) gene. APC is involved in the regulation of the cellular level of beta-catenin, which is a mediator in Wnt signaling.
S, Tejpar +10 more
openaire +2 more sources
Beta-Catenin in Pseudoexfoliation Syndrome [PDF]
Applied Sciences, 2020 To find whether it is possible that beta-catenin, associated with the development of serious systemic diseases, as well as the neoplastic process, plays a role in the development of pseudoexfoliation syndrome (PEX). If so, identifying PEX, an age-related, vision-threatening disorder of elastic fibers, which is manifested in eyes by the accumulation of ...
Joanna Stafiej +5 more
openaire +2 more sources
Beta-catenin expression in psoriasis
Indian Dermatology Online Journal, 2015 Psoriasis is a common inflammatory skin disease characterized by abnormal keratinocyte proliferation and differentiation. Beta-catenin participates in intercellular adhesion. Catenins are proteins found in complexes with cadherin cell adhesion molecules of cells. The role of catenin in regulating keratinocyte stem cell differentiation and hair follicle
Mohamed Abd El-wahed Gaber +3 more
openaire +3 more sources
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source