β-catenin takes a HIT [PDF]
Cell Cycle, 2008 Histidine triad (HIT) proteins represent a small family of nucleotide-binding and -hydrolyzing proteins, which attracted the attention of cancer biologists because their expression is lost in multiple human malignancies. To some of the family members including Fhit, Hint1 and Hint2, a tumor suppressive activity was assigned.
Otmar, Huber, Jörg, Weiske
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The vitamin D receptor is a Wnt effector that controls hair follicle differentiation and specifies tumor type in adult epidermis. [PDF]
PLoS ONE, 2008 We have investigated how Wnt and vitamin D receptor signals regulate epidermal differentiation. Many epidermal genes induced by beta-catenin, including the stem cell marker keratin 15, contain vitamin D response elements (VDREs) and several are induced ...
Héctor G Pálmer +4 more
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Cadherin-bound beta-catenin feeds into the Wnt pathway upon adherens junctions dissociation: evidence for an intersection between beta-catenin pools. [PDF]
PLoS ONE, 2009 Beta-catenin is an essential component of two cellular systems: cadherin-based adherens junctions (AJ) and the Wnt signaling pathway. A functional or physical connection between these beta-catenin pools has been suggested in previous studies, but not ...
Yoonseok Kam, Vito Quaranta
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Accumulation of phosphorylated beta-catenin enhances ROS-induced cell death in presenilin-deficient cells. [PDF]
PLoS ONE, 2009 Presenilin (PS) is involved in many cellular events under physiological and pathological conditions. Previous reports have revealed that PS deficiency results in hyperproliferation and resistance to apoptotic cell death.
Jung H Boo +4 more
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P53 and Beta-Catenin Activity during Estrogen treatment of Osteoblasts
Cancer Cell International, 2005 Background This study was undertaken to examine the relationship between the tumor suppressor gene p53 and the nuclear signaling protein beta-catenin during bone differentiation.
Kolman Kevin +4 more
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Journal of Oral and Maxillofacial Pathology, 2016 In continuation with the previous review on "β-catenin in health", in this review we discuss the role of β-catenin in the pathogenesis of common oral lesions in the oral and maxillofacial region- oral potentially malignant disorders, their progression to oral squamous cell carcinoma, salivary gland tumors and odontogenic tumours.
Prakash, Sharada +3 more
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In melanoma, beta-catenin is a suppressor of invasion [PDF]
Oncogene, 2011 Cell-type-specific signalling determines cell fate under physiological conditions, but it is increasingly apparent that also in cancer development the impact of any given oncogenic pathway on the individual cancer pathology is dependent on cell-lineage-specific molecular traits.
Arozarena, I +5 more
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Brain Beta-Catenin Signalling During Stress and Depression
Neurosignals, 2018 Beta-catenin is a protein with dual functions in the cell, playing a role in both adhesion between cells as well as gene transcription via the canonical Wnt signalling pathway.
Chuin Hau Teo +2 more
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Beta-catenin phosphorylated at serine 45 is spatially uncoupled from beta-catenin phosphorylated in the GSK3 domain: implications for signaling. [PDF]
PLoS ONE, 2010 C. elegans and Drosophila generate distinct signaling and adhesive forms of beta-catenin at the level of gene expression. Whether vertebrates, which rely on a single beta-catenin gene, generate unique adhesive and signaling forms at the level of protein ...
Meghan T Maher +4 more
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MicroRNA roles in beta-catenin pathway [PDF]
Molecular Cancer, 2010 Abstractβ-catenin, a key factor in the Wnt signaling pathway, has essential functions in the regulation of cell growth and differentiation. Aberrant β-catenin signaling has been linked to various disease pathologies, including an important role in tumorigenesis.
Han Lei +6 more
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