Results 21 to 30 of about 135,228 (293)

Physiological beta-catenin signaling controls self-renewal networks and generation of stem-like cells from nasopharyngeal carcinoma [PDF]

, 2013
BACKGROUND: A few reports suggested that low levels of Wnt signaling might drive cell reprogramming, but these studies could not establish a clear relationship between Wnt signaling and self-renewal networks.
Cheng, Y, Cheung, AKL, Chiu, PM, Ko, JMY, Lo, PH, Lung, ML, Phoon, YP, Waterman, ML   +7 more
core   +2 more sources

Beta-catenin in disease

Journal of Oral and Maxillofacial Pathology, 2016
In continuation with the previous review on "β-catenin in health", in this review we discuss the role of β-catenin in the pathogenesis of common oral lesions in the oral and maxillofacial region- oral potentially malignant disorders, their progression to oral squamous cell carcinoma, salivary gland tumors and odontogenic tumours.
Prakash, Sharada, Swaminathan, Uma, Nagamalini, BR, Krishnamurthy, Ashwini Balkuntla   +3 more
openaire   +3 more sources

Expression of dickkopf-1 and beta-catenin related to the prognosis of breast cancer patients with triple negative phenotype. [PDF]

PLoS ONE, 2012
BACKGROUND AND AIM: We investigated the prognostic importance of dickkopf-1(DKK1) and beta-catenin expression in triple negative breast cancers. METHODS: The expression of DKK1 and beta-catenin was evaluated in breast cell lines using RT-PCR and western ...
Wen-Huan Xu, Zhe-Bin Liu, Chen Yang, Wenxin Qin, Zhi-Ming Shao   +4 more
doaj   +1 more source

Dissecting the impact of Frizzled receptors in Wnt/beta-catenin signaling of human mesenchymal stem cells [PDF]

, 2012
Wnt/beta-catenin signaling is of fundamental importance in the regulation of self-renewal, migration/invasion, and differentiation of human mesenchymal stem cells (hMSCs).
Capovilla, Simon, Fernsebner, Katharina, Geissler, Claudia, Jochum, Marianne, Kolben, Thomas, Lechner, Felix, Neth, Peter, Peroebner, Iris, Ruiz-Heinrich, Lourdes   +8 more
core   +2 more sources

HGF/c-Met related activation of β-catenin in hepatoblastoma

Journal of Experimental & Clinical Cancer Research, 2011
Background Activation of beta-catenin is a hallmark of hepatoblastoma (HB) and appears to play a crucial role in its pathogenesis. While aberrant accumulation of the beta-catenin is a common event in HB, mutations or deletions in CTNNB1 (beta-catenin ...
Turner Clinton, Miles Carina, Maibach Rudolf, Childs Margaret, Purcell Rachel, Zimmermann Arthur, Sullivan Michael   +6 more
doaj   +1 more source

A lentivirus-mediated genetic screen identifies dihydrofolate reductase (DHFR) as a modulator of beta-catenin/GSK3 signaling. [PDF]

PLoS ONE, 2009
The multi-protein beta-catenin destruction complex tightly regulates beta-catenin protein levels by shuttling beta-catenin to the proteasome. Glycogen synthase kinase 3beta (GSK3beta), a key serine/threonine kinase in the destruction complex, is ...
Richard A Klinghoffer, Jason Frazier, James Annis, Jason D Berndt, Brian S Roberts, William T Arthur, Raul Lacson, Xiaohua Douglas Zhang, Marc Ferrer, Randall T Moon, Michele A Cleary   +10 more
doaj   +1 more source

Beta-catenin expression in psoriasis

Indian Dermatology Online Journal, 2015
Psoriasis is a common inflammatory skin disease characterized by abnormal keratinocyte proliferation and differentiation. Beta-catenin participates in intercellular adhesion. Catenins are proteins found in complexes with cadherin cell adhesion molecules of cells. The role of catenin in regulating keratinocyte stem cell differentiation and hair follicle
Mohamed Abd El-wahed Gaber, Mona Abd El-Halim Kandil, Shawki Mahmoud El-Farargy, Doaa Abd Elmoniem Galbet   +3 more
openaire   +3 more sources

Molecular Genetics of Intracranial Meningiomas with Emphasis on Canonical Wnt Signalling. [PDF]

, 2016
Research over the last decade recognized the importance of novel molecular pathways in pathogenesis of intracranial meningiomas. In this review, we focus on human brain tumours meningiomas and the involvement of Wnt signalling pathway genes and proteins ...
Kafka, Anja, Lechpammer, Mirna, Pećina-Šlaus, Nives   +2 more
core   +2 more sources

Functions of p120ctn isoforms in cell-cell adhesion and intracellular signaling [PDF]

, 2012
The functions of many organs depend on the generation of an epithelium. The transition from a set of loosely connected nonpolarized cells to organized sheets of closely associated polarized epithelial cells requires the assembly of specialized cell ...
Pieters, Tim, van Hengel, Jolanda, Van Roy, Frans   +2 more
core   +2 more sources

Nuclear beta-catenin in mesenchymal tumors [PDF]

Modern Pathology, 2005
Beta-catenin is a crucial part of the Wnt and E-cadherin signalling pathways, which are involved in tumorigenesis. Dysregulation of these pathways allow beta-catenin to accumulate and translocate to the nucleus, where it may activate oncogenes. Such nuclear accumulation can be detected by immunohistochemistry, which may be useful in diagnosis. Although
Tony L, Ng, Allen M, Gown, Todd S, Barry, Maggie C U, Cheang, Andy K W, Chan, Dmitry A, Turbin, Forrest D, Hsu, Robert B, West, Torsten O, Nielsen   +8 more
openaire   +2 more sources