Results 21 to 30 of about 86,249 (262)

Expression of dickkopf-1 and beta-catenin related to the prognosis of breast cancer patients with triple negative phenotype. [PDF]

PLoS ONE, 2012
BACKGROUND AND AIM: We investigated the prognostic importance of dickkopf-1(DKK1) and beta-catenin expression in triple negative breast cancers. METHODS: The expression of DKK1 and beta-catenin was evaluated in breast cell lines using RT-PCR and western ...
Wen-Huan Xu, Zhe-Bin Liu, Chen Yang, Wenxin Qin, Zhi-Ming Shao   +4 more
doaj   +1 more source

Nuclear beta-catenin in mesenchymal tumors [PDF]

Modern Pathology, 2005
Beta-catenin is a crucial part of the Wnt and E-cadherin signalling pathways, which are involved in tumorigenesis. Dysregulation of these pathways allow beta-catenin to accumulate and translocate to the nucleus, where it may activate oncogenes. Such nuclear accumulation can be detected by immunohistochemistry, which may be useful in diagnosis. Although
Tony L, Ng, Allen M, Gown, Todd S, Barry, Maggie C U, Cheang, Andy K W, Chan, Dmitry A, Turbin, Forrest D, Hsu, Robert B, West, Torsten O, Nielsen   +8 more
openaire   +2 more sources

HGF/c-Met related activation of β-catenin in hepatoblastoma

Journal of Experimental & Clinical Cancer Research, 2011
Background Activation of beta-catenin is a hallmark of hepatoblastoma (HB) and appears to play a crucial role in its pathogenesis. While aberrant accumulation of the beta-catenin is a common event in HB, mutations or deletions in CTNNB1 (beta-catenin ...
Turner Clinton, Miles Carina, Maibach Rudolf, Childs Margaret, Purcell Rachel, Zimmermann Arthur, Sullivan Michael   +6 more
doaj   +1 more source

A lentivirus-mediated genetic screen identifies dihydrofolate reductase (DHFR) as a modulator of beta-catenin/GSK3 signaling. [PDF]

PLoS ONE, 2009
The multi-protein beta-catenin destruction complex tightly regulates beta-catenin protein levels by shuttling beta-catenin to the proteasome. Glycogen synthase kinase 3beta (GSK3beta), a key serine/threonine kinase in the destruction complex, is ...
Richard A Klinghoffer, Jason Frazier, James Annis, Jason D Berndt, Brian S Roberts, William T Arthur, Raul Lacson, Xiaohua Douglas Zhang, Marc Ferrer, Randall T Moon, Michele A Cleary   +10 more
doaj   +1 more source

Beta-catenin expression in psoriasis

Indian Dermatology Online Journal, 2015
Psoriasis is a common inflammatory skin disease characterized by abnormal keratinocyte proliferation and differentiation. Beta-catenin participates in intercellular adhesion. Catenins are proteins found in complexes with cadherin cell adhesion molecules of cells. The role of catenin in regulating keratinocyte stem cell differentiation and hair follicle
Mohamed Abd El-wahed Gaber, Mona Abd El-Halim Kandil, Shawki Mahmoud El-Farargy, Doaa Abd Elmoniem Galbet   +3 more
openaire   +3 more sources

Beta-Catenin in Pseudoexfoliation Syndrome [PDF]

Applied Sciences, 2020
To find whether it is possible that beta-catenin, associated with the development of serious systemic diseases, as well as the neoplastic process, plays a role in the development of pseudoexfoliation syndrome (PEX). If so, identifying PEX, an age-related, vision-threatening disorder of elastic fibers, which is manifested in eyes by the accumulation of ...
Joanna Stafiej, Marta Hałas-Wiśniewska, Magdalena Izdebska, Maciej Gagat, Alina Grzanka, Grażyna Malukiewicz   +5 more
openaire   +2 more sources

Predominance of beta-catenin mutations and beta-catenin dysregulation in sporadic aggressive fibromatosis (desmoid tumor) [PDF]

Oncogene, 1999
Aggressive fibromatosis (also called desmoid tumor) occurs as a sporadic lesion or as part of Familial Adenomatous Polyposis, which is caused by germ line mutations in the Adenomatous polyposis Coli (APC) gene. APC is involved in the regulation of the cellular level of beta-catenin, which is a mediator in Wnt signaling.
S, Tejpar, F, Nollet, C, Li, J S, Wunder, G, Michils, P, dal Cin, E, Van Cutsem, B, Bapat, F, van Roy, J J, Cassiman, B A, Alman   +10 more
openaire   +2 more sources

Functional Wnt signaling is increased in idiopathic pulmonary fibrosis. [PDF]

PLoS ONE, 2008
BackgroundIdiopathic pulmonary fibrosis (IPF) is a fatal lung disease, characterized by distorted lung architecture and loss of respiratory function.
Melanie Königshoff, Nisha Balsara, Eva-Maria Pfaff, Monika Kramer, Izabella Chrobak, Werner Seeger, Oliver Eickelberg   +6 more
doaj   +1 more source

Dlg1 activates beta-catenin signaling to regulate retinal angiogenesis and the blood-retina and blood-brain barriers

eLife, 2019
Beta-catenin (i.e., canonical Wnt) signaling controls CNS angiogenesis and the blood-brain and blood-retina barriers. To explore the role of the Discs large/membrane-associated guanylate kinase (Dlg/MAGUK) family of scaffolding proteins in beta-catenin ...
Chris Cho, Yanshu Wang, Philip M Smallwood, John Williams, Jeremy Nathans   +4 more
doaj   +1 more source

Regulation of slow and fast muscle myofibrillogenesis by Wnt/beta-catenin and myostatin signaling. [PDF]

PLoS ONE, 2009
Deviation from proper muscle development or homeostasis results in various myopathic conditions. Employing genetic as well as chemical intervention, we provide evidence that a tight regulation of Wnt/beta-catenin signaling is essential for muscle fiber ...
Jin-Ming Tee, Carina van Rooijen, Rick Boonen, Danica Zivkovic   +3 more
doaj   +1 more source