Results 21 to 30 of about 865,952 (246)

Expression of dickkopf-1 and beta-catenin related to the prognosis of breast cancer patients with triple negative phenotype. [PDF]

PLoS ONE, 2012
BACKGROUND AND AIM: We investigated the prognostic importance of dickkopf-1(DKK1) and beta-catenin expression in triple negative breast cancers. METHODS: The expression of DKK1 and beta-catenin was evaluated in breast cell lines using RT-PCR and western ...
Wen-Huan Xu, Zhe-Bin Liu, Chen Yang, Wenxin Qin, Zhi-Ming Shao   +4 more
doaj   +1 more source

The FAM deubiquitylating enzyme localizes to multiple points of protein trafficking in epithelia, where it associates with E-cadherin and beta-catenin [PDF]

, 2004
Copyright © 2004 by The American Society for Cell Biology.Ubiquitylation is a necessary step in the endocytosis and lysosomal trafficking of many plasma membrane proteins and can also influence protein trafficking in the biosynthetic pathway.
Murray, Rachael, Murray, RZ, Wood, S., Wood, SA, Wood, Stephen J., Jolly, LA, A. Jolly, Lachlan, A. Wood, Stephen, Jolly, Lachlan, Murray, R., Jolly, L., Z. Murray, Rachael   +11 more
core   +2 more sources

HGF/c-Met related activation of β-catenin in hepatoblastoma

Journal of Experimental & Clinical Cancer Research, 2011
Background Activation of beta-catenin is a hallmark of hepatoblastoma (HB) and appears to play a crucial role in its pathogenesis. While aberrant accumulation of the beta-catenin is a common event in HB, mutations or deletions in CTNNB1 (beta-catenin ...
Turner Clinton, Miles Carina, Maibach Rudolf, Childs Margaret, Purcell Rachel, Zimmermann Arthur, Sullivan Michael   +6 more
doaj   +1 more source

A lentivirus-mediated genetic screen identifies dihydrofolate reductase (DHFR) as a modulator of beta-catenin/GSK3 signaling. [PDF]

PLoS ONE, 2009
The multi-protein beta-catenin destruction complex tightly regulates beta-catenin protein levels by shuttling beta-catenin to the proteasome. Glycogen synthase kinase 3beta (GSK3beta), a key serine/threonine kinase in the destruction complex, is ...
Richard A Klinghoffer, Jason Frazier, James Annis, Jason D Berndt, Brian S Roberts, William T Arthur, Raul Lacson, Xiaohua Douglas Zhang, Marc Ferrer, Randall T Moon, Michele A Cleary   +10 more
doaj   +1 more source

Wnt/beta-catenin signaling controls development of the blood–brain barrier [PDF]

, 2008
The blood–brain barrier (BBB) is confined to the endothelium of brain capillaries and is indispensable for fluid homeostasis and neuronal function. In this study, we show that endothelial Wnt/beta-catenin (beta-cat) signaling regulates induction and ...
Fruttiger, Marcus, Hartwig Wolburg, Babbage, J., M. Corada, Taddei, A., Monica Corada, Babbage, Jane, Wolburg, Hartwig, Corada, M., Makoto M. Taketo, Plate, Karl, A. Felici, Wolburg, H., C. J. Czupalla, Karl Heinz Plate, Harald von Melchner, Reis, M., E. Dejana, Gerhardt, Holger, Elisabetta Dejana, Marcus Fruttiger, M. Fruttiger, Dejana, Elisabetta, Angelina Felici, Jane Babbage, Taddei, Andrea, Liebner, S., Taketo, Makoto Mark, Felici, A., Liebner, Stefan, K. H. Plate, Reis, Marco, Bangsow, T., Dejana, E., M. Reis, Marco Reis, Czupalla, C.J., T. Bangsow, Cathrin J. Czupalla, A. Taddei, Felici, Angelina, H. von Melchner, Andrea Taddei, H. Wolburg, Taketo, M.M., von Melchner, H., J. Babbage, H. Gerhardt, Plate, K.H., Corada, Monica, M. M. Taketo, Czupalla, Cathrin Jacqueline, Holger Gerhardt, Stefan Liebner, S. Liebner, Fruttiger, M., Gerhardt, H., Bangsow, Thorsten, Melchner, Harald von (Prof. Dr.), Thorsten Bangsow   +59 more
core   +1 more source

Fusion of the BCL9 HD2 domain to E1A increases the cytopathic effect of an oncolytic adenovirus that targets colon cancer cells [PDF]

, 2006
Swiss Cancer League, Swiss National Science Foundation and SNSF NCCR Molecular Oncology ProgrammeBackground: The Wnt signaling pathway is activated by mutations in the APC and beta-catenin genes in many types of human cancer.
Homicsko, Krisztian, Pittet Anne-Laure, Christophe Fuerer, Lukashev, Alexander N., Homicsko Krisztian, Alexander N Lukashev, Fuerer Christophe, Anne-Laure Pittet, Iggo, Richard D., Fuerer, Christophe, Pittet, Anne-Laure, Richard D Iggo, Lukashev Alexander N, Iggo Richard D, Krisztian Homicsko, Iggo, R.D., Fuerer, C., Homicsko, K., Pittet, A.L., Lukashev, A.N.   +19 more
core   +2 more sources

Functional Wnt signaling is increased in idiopathic pulmonary fibrosis. [PDF]

PLoS ONE, 2008
BackgroundIdiopathic pulmonary fibrosis (IPF) is a fatal lung disease, characterized by distorted lung architecture and loss of respiratory function.
Melanie Königshoff, Nisha Balsara, Eva-Maria Pfaff, Monika Kramer, Izabella Chrobak, Werner Seeger, Oliver Eickelberg   +6 more
doaj   +1 more source

An immunohistochemical study of beta-catenin in HNPCC colon tumours [PDF]

, 2004
Includes bibliographical references (leaves 49-55).Beta-catenin is normally complexed with adenomatous polyposis coli (APC) protein and E-cadherin adhesion molecule, and localized on the cell membrane.
Watkins, Jennifer G
core   +1 more source

Regulation of slow and fast muscle myofibrillogenesis by Wnt/beta-catenin and myostatin signaling. [PDF]

PLoS ONE, 2009
Deviation from proper muscle development or homeostasis results in various myopathic conditions. Employing genetic as well as chemical intervention, we provide evidence that a tight regulation of Wnt/beta-catenin signaling is essential for muscle fiber ...
Jin-Ming Tee, Carina van Rooijen, Rick Boonen, Danica Zivkovic   +3 more
doaj   +1 more source

Dlg1 activates beta-catenin signaling to regulate retinal angiogenesis and the blood-retina and blood-brain barriers

eLife, 2019
Beta-catenin (i.e., canonical Wnt) signaling controls CNS angiogenesis and the blood-brain and blood-retina barriers. To explore the role of the Discs large/membrane-associated guanylate kinase (Dlg/MAGUK) family of scaffolding proteins in beta-catenin ...
Chris Cho, Yanshu Wang, Philip M Smallwood, John Williams, Jeremy Nathans   +4 more
doaj   +1 more source