Receptor and secreted targets of Wnt-1/beta-catenin signalling in mouse mammary epithelial cells. [PDF]
, 2005 BackgroundDeregulation of the Wnt/ beta-catenin signal transduction pathway has been implicated in the pathogenesis of tumours in the mammary gland, colon and other tissues. Mutations in components of this pathway result in beta-catenin stabilization and
Ashworth, Alan +2 more
core +3 more sources
Alteration of Subcellular Beta Catenin Expression in Normal Mucosa Adenoma and Carcinoma in Relation to Colorectal Carcinogenesis [PDF]
, 2010 Background: Adenomatous polyposis coli (APC) gene mutation was found in up to 80% of cases of sporadic colorectal cancers and adenomas. Loss of APC protein function has been known as one of the early process in colorectal carcinogenesis. This event leads
Abineno, P. D. (Pamela) +2 more
core +1 more source
Brain Beta-Catenin Signalling During Stress and Depression
Neurosignals, 2018 Beta-catenin is a protein with dual functions in the cell, playing a role in both adhesion between cells as well as gene transcription via the canonical Wnt signalling pathway.
Chuin Hau Teo +2 more
doaj +1 more source
Beta-catenin phosphorylated at serine 45 is spatially uncoupled from beta-catenin phosphorylated in the GSK3 domain: implications for signaling. [PDF]
PLoS ONE, 2010 C. elegans and Drosophila generate distinct signaling and adhesive forms of beta-catenin at the level of gene expression. Whether vertebrates, which rely on a single beta-catenin gene, generate unique adhesive and signaling forms at the level of protein ...
Meghan T Maher +4 more
doaj +1 more source
Physiological beta-catenin signaling controls self-renewal networks and generation of stem-like cells from nasopharyngeal carcinoma [PDF]
, 2013 BACKGROUND: A few reports suggested that low levels of Wnt signaling might drive cell reprogramming, but these studies could not establish a clear relationship between Wnt signaling and self-renewal networks.
Cheng, Y +7 more
core +2 more sources
Expression of dickkopf-1 and beta-catenin related to the prognosis of breast cancer patients with triple negative phenotype. [PDF]
PLoS ONE, 2012 BACKGROUND AND AIM: We investigated the prognostic importance of dickkopf-1(DKK1) and beta-catenin expression in triple negative breast cancers. METHODS: The expression of DKK1 and beta-catenin was evaluated in breast cell lines using RT-PCR and western ...
Wen-Huan Xu +4 more
doaj +1 more source
Dissecting the impact of Frizzled receptors in Wnt/beta-catenin signaling of human mesenchymal stem cells [PDF]
, 2012 Wnt/beta-catenin signaling is of fundamental importance in the regulation of self-renewal, migration/invasion, and differentiation of human mesenchymal stem cells (hMSCs).
Capovilla, Simon +8 more
core +2 more sources
OSTM1 regulates beta-catenin/Lef1 interaction and is required for Wnt/beta-catenin signaling [PDF]
, 2008 The Wnt/beta-catenin signaling pathway controls key aspects of embryonic development and adult tissue homeostasis, including the formation and maintenance of bone.
Feigin, M. E., Malbon, C. C.
core +1 more source
HGF/c-Met related activation of β-catenin in hepatoblastoma
Journal of Experimental & Clinical Cancer Research, 2011 Background Activation of beta-catenin is a hallmark of hepatoblastoma (HB) and appears to play a crucial role in its pathogenesis. While aberrant accumulation of the beta-catenin is a common event in HB, mutations or deletions in CTNNB1 (beta-catenin ...
Turner Clinton +6 more
doaj +1 more source
A lentivirus-mediated genetic screen identifies dihydrofolate reductase (DHFR) as a modulator of beta-catenin/GSK3 signaling. [PDF]
PLoS ONE, 2009 The multi-protein beta-catenin destruction complex tightly regulates beta-catenin protein levels by shuttling beta-catenin to the proteasome. Glycogen synthase kinase 3beta (GSK3beta), a key serine/threonine kinase in the destruction complex, is ...
Richard A Klinghoffer +10 more
doaj +1 more source