Results 21 to 30 of about 94,567 (312)

Brain Beta-Catenin Signalling During Stress and Depression

Neurosignals, 2018
Beta-catenin is a protein with dual functions in the cell, playing a role in both adhesion between cells as well as gene transcription via the canonical Wnt signalling pathway.
Chuin Hau Teo, Tomoko Soga, Ishwar S. Parhar   +2 more
doaj   +1 more source

In melanoma, beta-catenin is a suppressor of invasion [PDF]

Oncogene, 2011
Cell-type-specific signalling determines cell fate under physiological conditions, but it is increasingly apparent that also in cancer development the impact of any given oncogenic pathway on the individual cancer pathology is dependent on cell-lineage-specific molecular traits.
Arozarena, I, Bischof, H, Gilby, D, Belloni, B, Dummer, R, Wellbrock, C   +5 more
openaire   +3 more sources

Beta-catenin phosphorylated at serine 45 is spatially uncoupled from beta-catenin phosphorylated in the GSK3 domain: implications for signaling. [PDF]

PLoS ONE, 2010
C. elegans and Drosophila generate distinct signaling and adhesive forms of beta-catenin at the level of gene expression. Whether vertebrates, which rely on a single beta-catenin gene, generate unique adhesive and signaling forms at the level of protein ...
Meghan T Maher, Rigen Mo, Annette S Flozak, Ofra N Peled, Cara J Gottardi   +4 more
doaj   +1 more source

Expression of dickkopf-1 and beta-catenin related to the prognosis of breast cancer patients with triple negative phenotype. [PDF]

PLoS ONE, 2012
BACKGROUND AND AIM: We investigated the prognostic importance of dickkopf-1(DKK1) and beta-catenin expression in triple negative breast cancers. METHODS: The expression of DKK1 and beta-catenin was evaluated in breast cell lines using RT-PCR and western ...
Wen-Huan Xu, Zhe-Bin Liu, Chen Yang, Wenxin Qin, Zhi-Ming Shao   +4 more
doaj   +1 more source

Fusion of the BCL9 HD2 domain to E1A increases the cytopathic effect of an oncolytic adenovirus that targets colon cancer cells [PDF]

, 2006
Swiss Cancer League, Swiss National Science Foundation and SNSF NCCR Molecular Oncology ProgrammeBackground: The Wnt signaling pathway is activated by mutations in the APC and beta-catenin genes in many types of human cancer.
Homicsko, Krisztian, Pittet Anne-Laure, Christophe Fuerer, Lukashev, Alexander N., Homicsko Krisztian, Alexander N Lukashev, Fuerer Christophe, Anne-Laure Pittet, Iggo, Richard D., Fuerer, Christophe, Pittet, Anne-Laure, Richard D Iggo, Lukashev Alexander N, Iggo Richard D, Krisztian Homicsko   +14 more
core   +1 more source

HGF/c-Met related activation of β-catenin in hepatoblastoma

Journal of Experimental & Clinical Cancer Research, 2011
Background Activation of beta-catenin is a hallmark of hepatoblastoma (HB) and appears to play a crucial role in its pathogenesis. While aberrant accumulation of the beta-catenin is a common event in HB, mutations or deletions in CTNNB1 (beta-catenin ...
Turner Clinton, Miles Carina, Maibach Rudolf, Childs Margaret, Purcell Rachel, Zimmermann Arthur, Sullivan Michael   +6 more
doaj   +1 more source

A lentivirus-mediated genetic screen identifies dihydrofolate reductase (DHFR) as a modulator of beta-catenin/GSK3 signaling. [PDF]

PLoS ONE, 2009
The multi-protein beta-catenin destruction complex tightly regulates beta-catenin protein levels by shuttling beta-catenin to the proteasome. Glycogen synthase kinase 3beta (GSK3beta), a key serine/threonine kinase in the destruction complex, is ...
Richard A Klinghoffer, Jason Frazier, James Annis, Jason D Berndt, Brian S Roberts, William T Arthur, Raul Lacson, Xiaohua Douglas Zhang, Marc Ferrer, Randall T Moon, Michele A Cleary   +10 more
doaj   +1 more source

Nuclear beta-catenin in mesenchymal tumors [PDF]

Modern Pathology, 2005
Beta-catenin is a crucial part of the Wnt and E-cadherin signalling pathways, which are involved in tumorigenesis. Dysregulation of these pathways allow beta-catenin to accumulate and translocate to the nucleus, where it may activate oncogenes. Such nuclear accumulation can be detected by immunohistochemistry, which may be useful in diagnosis. Although
Tony L, Ng, Allen M, Gown, Todd S, Barry, Maggie C U, Cheang, Andy K W, Chan, Dmitry A, Turbin, Forrest D, Hsu, Robert B, West, Torsten O, Nielsen   +8 more
openaire   +2 more sources

Silencing mutated β-catenin inhibits cell proliferation and stimulates apoptosis in the adrenocortical cancer cell line H295R [PDF]

, 2013
Adrenocortical carcinoma (ACC) is a rare and highly aggressive endocrine neoplasm, with limited therapeutic options. Activating β-catenin somatic mutations are found in ACC and have been associated with a poor clinical outcome. In fact, activation of the
Lucile Lefèvre, Ragazzon, Bruno, Constanze Hantel (280561), Guillaud-Bataille, Marine, Bruno Ragazzon (140444), Launay, Pierre, Stéphane Bonnet (280565), Marthe Rizk-Rabin (280575), Marine Guillaud-Bataille (9131), Karine Perlemoine, Lefèvre, Lucile, Sébastien Gaujoux (280559), Tissier, Frédérique, Hantel, Constanze, Frédérique Tissier (140448), Lucile Lefèvre (280570), Rizk-Rabin, Marthe, Karine Perlemoine (280567), Bertherat, Jérôme, Stéphane Bonnet, Bonnet, Stéphane, Sébastien Gaujoux, Perlemoine, Karine, Jérôme Bertherat, Bruno Ragazzon, Beuschlein, Felix, Marthe Rizk-Rabin, Frédérique Tissier, Pierre Launay (280563), Jérôme Bertherat (140471), Felix Beuschlein, Marine Guillaud-Bataille, Constanze Hantel, Felix Beuschlein (158361), Gaujoux, Sébastien, Pierre Launay   +35 more
core   +1 more source

Predominance of beta-catenin mutations and beta-catenin dysregulation in sporadic aggressive fibromatosis (desmoid tumor) [PDF]

Oncogene, 1999
Aggressive fibromatosis (also called desmoid tumor) occurs as a sporadic lesion or as part of Familial Adenomatous Polyposis, which is caused by germ line mutations in the Adenomatous polyposis Coli (APC) gene. APC is involved in the regulation of the cellular level of beta-catenin, which is a mediator in Wnt signaling.
S, Tejpar, F, Nollet, C, Li, J S, Wunder, G, Michils, P, dal Cin, E, Van Cutsem, B, Bapat, F, van Roy, J J, Cassiman, B A, Alman   +10 more
openaire   +2 more sources