Cadherin-bound beta-catenin feeds into the Wnt pathway upon adherens junctions dissociation: evidence for an intersection between beta-catenin pools. [PDF]
PLoS ONE, 2009 Beta-catenin is an essential component of two cellular systems: cadherin-based adherens junctions (AJ) and the Wnt signaling pathway. A functional or physical connection between these beta-catenin pools has been suggested in previous studies, but not ...
Yoonseok Kam, Vito Quaranta
doaj +1 more source
Accumulation of phosphorylated beta-catenin enhances ROS-induced cell death in presenilin-deficient cells. [PDF]
PLoS ONE, 2009 Presenilin (PS) is involved in many cellular events under physiological and pathological conditions. Previous reports have revealed that PS deficiency results in hyperproliferation and resistance to apoptotic cell death.
Jung H Boo +4 more
doaj +1 more source
β-catenin takes a HIT [PDF]
Cell Cycle, 2008 Histidine triad (HIT) proteins represent a small family of nucleotide-binding and -hydrolyzing proteins, which attracted the attention of cancer biologists because their expression is lost in multiple human malignancies. To some of the family members including Fhit, Hint1 and Hint2, a tumor suppressive activity was assigned.
Otmar, Huber, Jörg, Weiske
openaire +2 more sources
P53 and Beta-Catenin Activity during Estrogen treatment of Osteoblasts
Cancer Cell International, 2005 Background This study was undertaken to examine the relationship between the tumor suppressor gene p53 and the nuclear signaling protein beta-catenin during bone differentiation.
Kolman Kevin +4 more
doaj +1 more source
Journal of Oral and Maxillofacial Pathology, 2016 In continuation with the previous review on "β-catenin in health", in this review we discuss the role of β-catenin in the pathogenesis of common oral lesions in the oral and maxillofacial region- oral potentially malignant disorders, their progression to oral squamous cell carcinoma, salivary gland tumors and odontogenic tumours.
Prakash, Sharada +3 more
openaire +3 more sources
Brain Beta-Catenin Signalling During Stress and Depression
Neurosignals, 2018 Beta-catenin is a protein with dual functions in the cell, playing a role in both adhesion between cells as well as gene transcription via the canonical Wnt signalling pathway.
Chuin Hau Teo +2 more
doaj +1 more source
Beta-catenin phosphorylated at serine 45 is spatially uncoupled from beta-catenin phosphorylated in the GSK3 domain: implications for signaling. [PDF]
PLoS ONE, 2010 C. elegans and Drosophila generate distinct signaling and adhesive forms of beta-catenin at the level of gene expression. Whether vertebrates, which rely on a single beta-catenin gene, generate unique adhesive and signaling forms at the level of protein ...
Meghan T Maher +4 more
doaj +1 more source
Expression of dickkopf-1 and beta-catenin related to the prognosis of breast cancer patients with triple negative phenotype. [PDF]
PLoS ONE, 2012 BACKGROUND AND AIM: We investigated the prognostic importance of dickkopf-1(DKK1) and beta-catenin expression in triple negative breast cancers. METHODS: The expression of DKK1 and beta-catenin was evaluated in breast cell lines using RT-PCR and western ...
Wen-Huan Xu +4 more
doaj +1 more source
HGF/c-Met related activation of β-catenin in hepatoblastoma
Journal of Experimental & Clinical Cancer Research, 2011 Background Activation of beta-catenin is a hallmark of hepatoblastoma (HB) and appears to play a crucial role in its pathogenesis. While aberrant accumulation of the beta-catenin is a common event in HB, mutations or deletions in CTNNB1 (beta-catenin ...
Turner Clinton +6 more
doaj +1 more source
A lentivirus-mediated genetic screen identifies dihydrofolate reductase (DHFR) as a modulator of beta-catenin/GSK3 signaling. [PDF]
PLoS ONE, 2009 The multi-protein beta-catenin destruction complex tightly regulates beta-catenin protein levels by shuttling beta-catenin to the proteasome. Glycogen synthase kinase 3beta (GSK3beta), a key serine/threonine kinase in the destruction complex, is ...
Richard A Klinghoffer +10 more
doaj +1 more source