MicroRNA roles in beta-catenin pathway [PDF]
Molecular Cancer, 2010 Abstractβ-catenin, a key factor in the Wnt signaling pathway, has essential functions in the regulation of cell growth and differentiation. Aberrant β-catenin signaling has been linked to various disease pathologies, including an important role in tumorigenesis.
Han Lei +6 more
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Proceedings of the National Academy of Sciences of the United States of America, 1995 S Munemitsu +4 more
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Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6. [PDF]
PLoS ONE, 2009 The Wnt/beta-catenin signaling pathway plays essential roles in cell proliferation and differentiation, and deregulated beta-catenin protein levels lead to many types of human cancers.
Geng Wu +3 more
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Beta-catenin signaling negatively regulates intermediate progenitor population numbers in the developing cortex. [PDF]
PLoS ONE, 2010 Intermediate progenitor cells constitute a second proliferative cell type in the developing mammalian cerebral cortex. Little is known about the factors that govern the production of intermediate progenitors.
Christopher A Mutch +3 more
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The vitamin D receptor is a Wnt effector that controls hair follicle differentiation and specifies tumor type in adult epidermis. [PDF]
PLoS ONE, 2008 We have investigated how Wnt and vitamin D receptor signals regulate epidermal differentiation. Many epidermal genes induced by beta-catenin, including the stem cell marker keratin 15, contain vitamin D response elements (VDREs) and several are induced ...
Héctor G Pálmer +4 more
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Cadherin-bound beta-catenin feeds into the Wnt pathway upon adherens junctions dissociation: evidence for an intersection between beta-catenin pools. [PDF]
PLoS ONE, 2009 Beta-catenin is an essential component of two cellular systems: cadherin-based adherens junctions (AJ) and the Wnt signaling pathway. A functional or physical connection between these beta-catenin pools has been suggested in previous studies, but not ...
Yoonseok Kam, Vito Quaranta
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Accumulation of phosphorylated beta-catenin enhances ROS-induced cell death in presenilin-deficient cells. [PDF]
PLoS ONE, 2009 Presenilin (PS) is involved in many cellular events under physiological and pathological conditions. Previous reports have revealed that PS deficiency results in hyperproliferation and resistance to apoptotic cell death.
Jung H Boo +4 more
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β-catenin takes a HIT [PDF]
Cell Cycle, 2008 Histidine triad (HIT) proteins represent a small family of nucleotide-binding and -hydrolyzing proteins, which attracted the attention of cancer biologists because their expression is lost in multiple human malignancies. To some of the family members including Fhit, Hint1 and Hint2, a tumor suppressive activity was assigned.
Otmar, Huber, Jörg, Weiske
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P53 and Beta-Catenin Activity during Estrogen treatment of Osteoblasts
Cancer Cell International, 2005 Background This study was undertaken to examine the relationship between the tumor suppressor gene p53 and the nuclear signaling protein beta-catenin during bone differentiation.
Kolman Kevin +4 more
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Wnt/beta-catenin/Tcf signaling: A critical pathway in gastrointestinal tumorigenesis [PDF]
, 2002 Cancers of the gastrointestinal tract, including the liver, bile ducts, and pancreas, constitute the largest group of malignant tumors. Colorectal cancer is one of the most common neoplastic diseases in Western countries and one of the leading causes of ...
Bommer, G., Göke, B., Kolligs, F. T.
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