Results 31 to 40 of about 336,645 (300)
WNT Signaling in Disease [PDF]
Cells, 2019 Developmental signaling pathways control a vast array of biological processes during embryogenesis and in adult life. The WNT pathway was discovered simultaneously in cancer and development. Recent advances have expanded the role of WNT to a wide range of pathologies in humans.
Li Ng +7 more
openaire +3 more sources
Cell Reports, 2014 Summary: WNT signaling promotes the reprogramming of somatic cells to an induced pluripotent state. We provide genetic evidence that WNT signaling is a requisite step during the induction of pluripotency.
Jason Ross +8 more
doaj +1 more source
A CRISPR knockout screen reveals new regulators of canonical Wnt signaling
Oncogenesis, 2021 The Wnt signaling pathways play fundamental roles during both development and adult homeostasis. Aberrant activation of the canonical Wnt signal transduction pathway is involved in many diseases including cancer, and is especially implicated in the ...
Tamar Evron +9 more
doaj +1 more source
Could an endoneurial endothelial crosstalk between Wnt/β-catenin and Sonic Hedgehog pathways underlie the early disruption of the infra-orbital blood-nerve barrier following chronic constriction injury? [PDF]
, 2017 BackgroundBlood–nerve barrier disruption is pivotal in the development of neuroinflammation, peripheral sensitization, and neuropathic pain after peripheral nerve injury.
Boucher, Yves +7 more
core +4 more sources
Wnt signaling in myogenesis [PDF]
Trends in Cell Biology, 2012 The formation of skeletal muscle is a tightly regulated process that is critically modulated by Wnt signaling. Myogenesis is dependent on the precise and dynamic integration of multiple Wnt signals allowing self-renewal and progression of muscle precursors in the myogenic lineage.
Julia, von Maltzahn +3 more
openaire +2 more sources
Synaptic Wnt/GSK3β Signaling Hub in Autism [PDF]
, 2016 Indexación: ScopusHundreds of genes have been associated with autism spectrum disorders (ASDs) and the interaction of weak and de novo variants derive from distinct autistic phenotypes thus making up the "spectrum." The convergence of these variants in ...
Avila, M.E. +2 more
core +1 more source
Wnt signaling potentiates nevogenesis [PDF]
Proceedings of the National Academy of Sciences, 2013 Significance Human benign nevi (moles) are clonal neoplasms that rarely progress to melanoma because their cells (melanocytes) are arrested in a viable but nonproliferating state (senescence). However, at low frequency, nevus melanocytes do progress to melanoma.
Pawlikowski, J.S. +9 more
openaire +4 more sources
Cancer Biology & Medicine, 2020 Objectives: Improper activation of Wnt/β-catenin signaling has been implicated in human diseases. Beyond the well-studied glycogen synthase kinase 3β (GSK3β) and casein kinase 1 (CK1), other kinases affecting Wnt/β-catenin signaling remain to be defined.
Danmin Ou +10 more
doaj +1 more source
High throughput genomic screen identifies multiple factors that promote cooperative Wnt signaling. [PDF]
PLoS ONE, 2013 Previous studies have demonstrated that certain Wnt ligands can promote high levels of cooperative signaling in a cell type specific manner. To explore the underlying mechanism of this cooperative Wnt signaling, we performed a high-throughput screen of ...
Mayumi F Miller +4 more
doaj +1 more source
Wnt/β-catenin signaling stimulates the expression and synaptic clustering of the autism-associated Neuroligin 3 gene [PDF]
, 2018 Indexación: Scopus.Synaptic abnormalities have been described in individuals with autism spectrum disorders (ASD). The cell-adhesion molecule Neuroligin-3 (Nlgn3) has an essential role in the function and maturation of synapses and NLGN3 ASD-associated ...
Andrade, V.M. +9 more
core +1 more source