Results 31 to 40 of about 1,133,912 (305)

Dissecting the roles of WNT signaling in breast cancer using "in vitro" and "in vivo" experimental models [PDF]

, 2009
Canonical WNT pathway regulates expression of target genes by modulating intracellular amount of β-catenin. Without WNT pathway activation, a so-called “destruction complex” including APC and Axin facilitates the degradation of β-catenin. Upon binding of
Matsuda, Yutaka
core   +1 more source

Wnt signaling in myogenesis [PDF]

Trends in Cell Biology, 2012
The formation of skeletal muscle is a tightly regulated process that is critically modulated by Wnt signaling. Myogenesis is dependent on the precise and dynamic integration of multiple Wnt signals allowing self-renewal and progression of muscle precursors in the myogenic lineage.
Julia, von Maltzahn, Natasha C, Chang, C Florian, Bentzinger, Michael A, Rudnicki   +3 more
openaire   +2 more sources

Persistent Wnt/β-catenin signaling determines dorsalization of the postnatal subventricular zone and neural Stem cell specification into oligodendrocytes and glutamatergic neurons [PDF]

, 2014
In the postnatal and adult central nervous system (CNS), the subventricular zone (SVZ) of the forebrain is the main source of neural stem cells (NSCs) that generate olfactory neurons and oligodendrocytes (OLs), the myelinating cells of the CNS.
Raineteau, Olivier, Fischer, Bruno,, Sommer, Lukas, Sommer, Lukas,, Draganova, Kalina,, Draganova, Kalina, Fischer, Bruno, Cantu, Claudio, Azim, Kasum,, Butt, Arthur, Raineteau, Olivier,, Butt, Arthur,, Azim, Kasum, Hurtado-Chong, Anahi,, Hurtado-Chong, Anahi, Cantù, Claudio,, Zemke, Martina, Zemke, Martina,, Butt A, Cantù C, Draganova K, Raineteau O, Sommer L, Fischer B, Zemke M, Hurtado-Chong A, Azim K   +26 more
core   +1 more source

Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma

Nature Communications, 2016
Cutaneous squamous cell carcinomas is a growing problem but the driver genes causing this remain poorly defined. Here, the authors demonstrate that inactivating driver mutations in TGFBR1 and TGFBR2occur in vemurafenib-induced and sporadic cutaneous ...
Patrizia Cammareri, Aidan M. Rose, David F. Vincent, Jun Wang, Ai Nagano, Silvana Libertini, Rachel A. Ridgway, Dimitris Athineos, Philip J. Coates, Angela McHugh, Celine Pourreyron, Jasbani H. S. Dayal, Jonas Larsson, Simone Weidlich, Lindsay C. Spender, Gopal P. Sapkota, Karin J. Purdie, Charlotte M. Proby, Catherine A. Harwood, Irene M. Leigh, Hans Clevers, Nick Barker, Stefan Karlsson, Catrin Pritchard, Richard Marais, Claude Chelala, Andrew P. South, Owen J. Sansom, Gareth J. Inman   +28 more
doaj   +1 more source

Running Against the Wnt: How Wnt/β-Catenin Suppresses Adipogenesis

Frontiers in Cell and Developmental Biology, 2021
Mesenchymal stem cells (MSCs) give rise to adipocytes, osteocytes, and chondrocytes and reside in various tissues, including bone marrow and adipose tissue.
Twan J. J. de Winter, Roeland Nusse, Roeland Nusse   +2 more
doaj   +1 more source

Impaired Mitochondrial ATP Production Downregulates Wnt Signaling via ER Stress Induction

Cell Reports, 2019
Summary: Wnt signaling affects fundamental development pathways and, if aberrantly activated, promotes the development of cancers. Wnt signaling is modulated by different factors, but whether the mitochondrial energetic state affects Wnt signaling is ...
Roberto Costa, Roberta Peruzzo, Magdalena Bachmann, Giulia Dalla Montà, Mattia Vicario, Giulia Santinon, Andrea Mattarei, Enrico Moro, Rubén Quintana-Cabrera, Luca Scorrano, Massimo Zeviani, Francesca Vallese, Mario Zoratti, Cristina Paradisi, Francesco Argenton, Marisa Brini, Tito Calì, Sirio Dupont, Ildikò Szabò, Luigi Leanza   +19 more
doaj   +1 more source

A CRISPR knockout screen reveals new regulators of canonical Wnt signaling

Oncogenesis, 2021
The Wnt signaling pathways play fundamental roles during both development and adult homeostasis. Aberrant activation of the canonical Wnt signal transduction pathway is involved in many diseases including cancer, and is especially implicated in the ...
Tamar Evron, Michal Caspi, Michal Kazelnik, Yarden Shor-Nareznoy, Shir Armoza-Eilat, Revital Kariv, Zohar Manber, Ran Elkon, Ella H. Sklan, Rina Rosin-Arbesfeld   +9 more
doaj   +1 more source

Maternal Wnt/β-catenin signaling coactivates transcription through NF-κB binding sites during Xenopus axis formation. [PDF]

, 2012
Maternal Wnt/β-Catenin signaling establishes a program of dorsal-specific gene expression required for axial patterning in Xenopus. We previously reported that a subset of dorsally expressed genes depends not only on Wnt/β-Catenin stimulation, but also ...
Rupp, Ralph A. W., Armstrong Neil J., Fagotto François, Christian Prothmann, Ralph A W Rupp, Prothmann, Christian, Neil J Armstrong, Rupp Ralph A. W., François Fagotto, Prothmann Christian, Fagotto, François, Armstrong, Neil J.   +11 more
core   +2 more sources

A Rare Human Syndrome Provides Genetic Evidence that WNT Signaling Is Required for Reprogramming of Fibroblasts to Induced Pluripotent Stem Cells

Cell Reports, 2014
Summary: WNT signaling promotes the reprogramming of somatic cells to an induced pluripotent state. We provide genetic evidence that WNT signaling is a requisite step during the induction of pluripotency.
Jason Ross, Julia Busch, Ellen Mintz, Damian Ng, Alexandra Stanley, David Brafman, V. Reid Sutton, Ignatia Van den Veyver, Karl Willert   +8 more
doaj   +1 more source

Wnt10b-GSK3β–dependent Wnt/STOP signaling prevents aneuploidy in human somatic cells

Life Science Alliance, 2021
Autocrine Wnt10b signaling ensures proper mitotic microtubule polymerization and faithful chromosome segregation. Wnt signaling is crucial for proper development, tissue homeostasis and cell cycle regulation.
Yu-Chih Lin, Alexander Haas, Anja Bufe, Sabnam Parbin, Magdalena Hennecke, Oksana Voloshanenko, Julia Gross, Michael Boutros, Sergio P Acebron, Holger Bastians   +9 more
doaj   +1 more source