Results 31 to 40 of about 209,276 (265)
Wnt10b-GSK3β–dependent Wnt/STOP signaling prevents aneuploidy in human somatic cells
Life Science Alliance, 2021 Autocrine Wnt10b signaling ensures proper mitotic microtubule polymerization and faithful chromosome segregation. Wnt signaling is crucial for proper development, tissue homeostasis and cell cycle regulation.
Yu-Chih Lin +9 more
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Wnt signaling and cancer [PDF]
Genes & Development, 2000 The regulation of cell growth and survival can be subverted by a variety of genetic defects that alter transcriptional programs normally responsible for controlling cell number. High throughput analysis of these gene expression patterns should ultimately lead to the identification of minimal expression profiles that will serve as common denominators in
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β-Arrestin interacts with the beta/gamma subunits of trimeric G-proteins and dishevelled in the Wnt/Ca(2+) pathway in xenopus gastrulation. [PDF]
PLoS ONE, 2014 β-Catenin independent, non-canonical Wnt signaling pathways play a major role in the regulation of morphogenetic movements in vertebrates. The term non-canonical Wnt signaling comprises multiple, intracellularly divergent, Wnt-activated and β-Catenin ...
Katharina Seitz +5 more
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Wnt Signaling in Angiogenesis [PDF]
Current Drug Targets, 2008 Although progress has been made in understanding the role of growth factors and their receptors in angiogenesis, little is known about how the Wnt family of growth factors function in the vasculature. Wnts are multifunctional factors that act through the frizzled receptors to regulate proliferation, apoptosis, branching morphogenesis, inductive ...
Nancy L, Parmalee, Jan, Kitajewski
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Wnt Signaling in Mitosis [PDF]
Developmental Cell, 2009 Previously, the connection between cell proliferation and Wnt signaling focused on transcriptional activation of cyclin D1 and c-myc, which control the G1/S transition of the cell cycle. In this issue of Developmental Cell, the Niehrs group demonstrates mitotic activation of Wnt signaling by a novel Cdk/cyclin complex containing Cdk14 (PFTK1) and ...
Kaldis, Philipp, Pagano, Michele
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Cancer Biology & Medicine, 2020 Objectives: Improper activation of Wnt/β-catenin signaling has been implicated in human diseases. Beyond the well-studied glycogen synthase kinase 3β (GSK3β) and casein kinase 1 (CK1), other kinases affecting Wnt/β-catenin signaling remain to be defined.
Danmin Ou +10 more
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High throughput genomic screen identifies multiple factors that promote cooperative Wnt signaling. [PDF]
PLoS ONE, 2013 Previous studies have demonstrated that certain Wnt ligands can promote high levels of cooperative signaling in a cell type specific manner. To explore the underlying mechanism of this cooperative Wnt signaling, we performed a high-throughput screen of ...
Mayumi F Miller +4 more
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Cell Reports, 2018 Summary: Wnt/β-catenin signaling is necessary for lymphatic vascular development. Oscillatory shear stress (OSS) enhances Wnt/β-catenin signaling in cultured lymphatic endothelial cells (LECs) to induce expression of the lymphedema-associated ...
Boksik Cha +16 more
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Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations
Pediatric Blood &Cancer, EarlyView.ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan +18 more
wiley +1 more source
Rethinking WNT signalling [PDF]
Nature, 2018 The identification of genetic mutations that can hinder the development of human limbs has led to the discovery of an unanticipated mode of regulation for the WNT signalling pathway during limb development. The identification of genetic mutations that can hinder the development of human limbs has led to the discovery of an unanticipated mode of ...
Jessica A, Lehoczky, Clifford J, Tabin
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