Results 21 to 30 of about 1,893,676 (290)

Wnt/β-catenin signaling pathway inhibits the proliferation and apoptosis of U87 glioma cells via different mechanisms. [PDF]

PLoS ONE, 2017
The Wnt signaling pathway is necessary for the development of the central nervous system and is associated with tumorigenesis in various cancers. However, the mechanism of the Wnt signaling pathway in glioma cells has yet to be elucidated. Small-molecule
Liyang Gao, Bing Chen, Jinhong Li, Fan Yang, Xuecheng Cen, Zhuangbing Liao, Xiao'ao Long   +6 more
doaj   +1 more source

Integration of SHH and WNT pathways controls morphogenesis of the CNS. [PDF]

, 2008
[eng] Dorsoventral patterning of the vertebrate nervous system is achieved by the combined activity of morphogenetic signals secreted from dorsal and ventral signalling centres. The Shh/Gli pathway plays a major role in patterning the ventral neural tube;
Álvarez Medina, José Roberto
core   +6 more sources

Interaction of viral oncogenic proteins with the Wnt signaling pathway [PDF]

Iranian Journal of Basic Medical Sciences, 2018
It is estimated that up to 20% of all types of human cancers worldwide are attributed to viruses. The genome of oncogenic viruses carries genes that have protein products that act as oncoproteins in cell proliferation and transformation.
Sayyad Khanizadeh, Banafshe Hasanvand, Hamed Esmaeil Lashgarian, Mohammad Almasian, Gholamreza Goudarzi   +4 more
doaj   +1 more source

Regulation of the WNT-CTNNB1 signaling pathway by severe fever with thrombocytopenia syndrome virus in a cap-snatching manner

mBio, 2023
The segmented negative-strand RNA viruses (sNSVs) include highly pathogenic human and animal viruses such as Lassa virus (LASV), severe fever with thrombocytopenia syndrome virus (SFTSV), and influenza A virus (IAV).
Xia-Ming Jiang, Qi-Lin Xin, Kai Liu, Xue-Fang Peng, Shuo Han, Ling-Yu Zhang, Wei Liu, Geng-Fu Xiao, Hao Li, Lei-Ke Zhang   +9 more
doaj   +1 more source

Wnt and the Wnt signaling pathway in bone development and disease [PDF]

Frontiers in Bioscience, 2014
Wnt signaling affects both bone modeling, which occurs during development, and bone remodeling, which is a lifelong process involving tissue renewal. Wnt signals are especially known to affect the differentiation of osteoblasts. In this review, we summarize recent advances in understanding the mechanisms of Wnt signaling, which is divided into two ...
Yiping, Wang, Yi-Ping, Li, Christie, Paulson, Jian-Zhong, Shao, Xiaoling, Zhang, Mengrui, Wu, Wei, Chen   +6 more
openaire   +2 more sources

A CRISPR knockout screen reveals new regulators of canonical Wnt signaling

Oncogenesis, 2021
The Wnt signaling pathways play fundamental roles during both development and adult homeostasis. Aberrant activation of the canonical Wnt signal transduction pathway is involved in many diseases including cancer, and is especially implicated in the ...
Tamar Evron, Michal Caspi, Michal Kazelnik, Yarden Shor-Nareznoy, Shir Armoza-Eilat, Revital Kariv, Zohar Manber, Ran Elkon, Ella H. Sklan, Rina Rosin-Arbesfeld   +9 more
doaj   +1 more source

Expression Levels of WNT Signaling Pathway Genes During Early Tooth Development

Organogenesis, 2023
It is known to all that Wnt signaling pathway plays an important role in the early development of tooth. Our previous research found that Wnt signaling pathway played crucial roles in dental development, and mutations in antagonist of Wnt signaling ...
Yuhan Song, Fujie Song, Xuan Xiao, Zhifeng Song, Shangfeng Liu   +4 more
doaj   +1 more source

Autophagy and the Wnt signaling pathway: A focus on Wnt/β-catenin signaling

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2021
Cellular homeostasis and adaptation to various environmental conditions are importantly regulated by the sophisticated mechanism of autophagy and its crosstalk with Wnt signaling and other developmental pathways. Both autophagy and Wnt signaling are involved in embryogenesis and differentiation. Autophagy is responsible for degradation and recycling of
Shahrokh, Lorzadeh, Leila, Kohan, Saeid, Ghavami, Negar, Azarpira   +3 more
openaire   +2 more sources

A phenotypic screen in zebrafish identifies a novel small-molecule inducer of ectopic tail formation suggestive of alterations in non-canonical Wnt/PCP signaling [PDF]

, 2013
Zebrafish have recently emerged as an attractive model for the in vivo bioassay-guided isolation and characterization of pharmacologically active small molecules of natural origin.
Alexander D. Crawford, Crawford, Alexander D, Alexander I. Gray, Cordero-Maldonado, María Lorena, de Witte, Peter A M, Gray, Alexander I, Alan L Harvey, Camila V. Esguerra, Gebruers, Evelien, Evelien Gebruers, Harvey, Alan L, Carol Clements, Clements, Carol, Alexander D Crawford, Edrada-Ebel, Ruangelie, Camila V Esguerra, Alan L. Harvey, Ruangelie Edrada-Ebel, Esguerra, Camila V, María Lorena Cordero-Maldonado, Alexander I Gray, Peter A M de Witte, Cordero Maldonado, María Lorena, Peter A. M. de Witte, Edrada-Ebel, R., CRAWFORD, Alexander Dettmar, De Witte, P. A. M., Crawford Alexander D., Clements Carol, de Witte Peter A. M., Cordero-Maldonado, M. L., Gebruers, E., Edrada-Ebel Ruangelie, Esguerra, C. V., Cordero-Maldonado María Lorena, Gray Alexander I., Clements, C., Gebruers Evelien, Harvey, A. L., Esguerra Camila V., Gray, A. I., Harvey Alan L.   +41 more
core   +4 more sources

Wnt/β-catenin signaling pathway in lung cancer

Medicine in Drug Discovery, 2022
The Wnt signaling pathway regulates cell proliferation, differentiation, migration, genetic stability, and apoptosis in almost all tissues and organs. It plays a crucial role in the normal development of embryos and the dynamic balance of adult tissues ...
Wenhua Zhu, Heng Wang, Di Zhu
doaj   +1 more source