Results 31 to 40 of about 284,518 (203)
Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023 Ovarian cancer is a malignant tumor of the female reproductive system with the highest mortality, and involves the aberrant regulation of multiple molecular signaling pathways.
ZHOU Wanzhen, TENG Yincheng
doaj +1 more source
Wnt signaling pathways meet Rho GTPases [PDF]
Genes & Development, 2009 Wnt ligands and their receptors orchestrate many essential cellular and physiological processes. During development they control differentiation, proliferation, migration, and patterning, while in the adult, they regulate tissue homeostasis, primarily through their effects on stem cell proliferation and differentiation.
Karni, Schlessinger +2 more
openaire +2 more sources
Role of Wnt canonical pathway in hematological malignancies
Journal of Hematology & Oncology, 2010 Wnt canonical signaling pathway plays a diverse role in embryonic development and maintenance of organs and tissues in adults. It has been observed that Wnt/β-catenin signaling pathway is involved in the pathogenesis of many carcinomas.
Wang Xin, GE Xueling
doaj +1 more source
The Wnt signaling pathway in cancer [PDF]
Critical Reviews in Oncology/Hematology, 2016 The Wnt signaling pathway is critically involved in both the development and homeostasis of tissues via regulation of their endogenous stem cells. Aberrant Wnt signaling has been described as a key player in the initiation of and/or maintenance and development of many cancers, via affecting the behavior of Cancer Stem Cells (CSCs).
Yann Duchartre +2 more
openaire +2 more sources
Regulation of SUMOylation Targets Associated With Wnt/β-Catenin Pathway
Frontiers in Oncology, 2022 Wnt/β-catenin signaling is a delicate and complex signal transduction pathway mediated by multiple signaling molecules, which plays a significant role in regulating human physiology and pathology.
Linlin Fan +6 more
doaj +1 more source
Could an endoneurial endothelial crosstalk between Wnt/β-catenin and Sonic Hedgehog pathways underlie the early disruption of the infra-orbital blood-nerve barrier following chronic constriction injury? [PDF]
, 2017 BackgroundBlood–nerve barrier disruption is pivotal in the development of neuroinflammation, peripheral sensitization, and neuropathic pain after peripheral nerve injury.
Boucher, Yves +7 more
core +4 more sources
SnapShot: Noncanonical Wnt Signaling Pathways
Cell, 2007 Noncanonical Wnt signaling is defined here as Wnt- or Fz-initiated signaling that is independent of β-catenin transcriptional function. Noncanonical Wnt pathways are diverse and in many cases less characterized/defined. They are grouped into several categories for clarity and simplicity.
Semenov, Mikhail V. +3 more
openaire +2 more sources
The Wnt Signaling Pathway in Diabetic Nephropathy [PDF]
Frontiers in Cell and Developmental Biology, 2022 Diabetic nephropathy (DN) is a serious kidney-related complication of both type 1 and type 2 diabetes mellitus (T1DM, T2DM) and the second major cause of end-stage kidney disease. DN can lead to hypertension, edema, and proteinuria. In some cases, DN can even progress to kidney failure, a life-threatening condition.
Haiying Wang +9 more
openaire +3 more sources
Acta Biochimica et Biophysica Sinica, 2023 Roof plate-specific spondin 1 (R-spondin1, RSPO1) is a Wnt/β-catenin signaling pathway activator that binds with Wnt ligands to stimulate the Wnt/β-catenin signaling pathway, which is key to hair regeneration. However, it is not clear whether recombinant
Chen Yijun +7 more
doaj +1 more source
Porcine Circovirus-Like Virus P1 Inhibits Wnt Signaling Pathway in Vivo and in Vitro
Frontiers in Microbiology, 2018 Porcine circovirus-like virus P1 is an important pathogen of the current pig industry, the infection mechanism is not entirely clear. Wnt signaling pathway plays an important role in the growth of young animals and infection of some viruses.
Xuejiao Zhu +24 more
doaj +1 more source