WTX beyond WNT signaling pathway
Visualized Cancer Medicine, 2023 Gastric cancer (GC) is a major malignancy in many developing countries with low early detection rate. As a tumour suppressor gene, WTX inhibits PI3K/AKT/mTOR pathway activity by inhibiting PI3K phosphorylation. WTX loss of WTX protein associates with tumor metastasis and poor survival of GC patients.
Zhang Qingling +3 more
openaire +2 more sources
Cyclin D1-mediated microRNA expression signature predicts breast cancer outcome [PDF]
, 2018 Background: Genetic classification of breast cancer based on the coding mRNA suggests the evolution of distinct subtypes. Whether the non-coding genome is altered concordantly with the coding genome and the mechanism by which the cell cycle directly ...
Addya, Sankar +16 more
core +2 more sources
Primary Cilia Formation Does Not Rely on WNT/β-Catenin Signaling
Frontiers in Cell and Developmental Biology, 2021 Primary cilia act as crucial regulators of embryo development and tissue homeostasis. They are instrumental for modulation of several signaling pathways, including Hedgehog, WNT, and TGF-β.
Ondrej Bernatik +4 more
doaj +1 more source
Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation [PDF]
, 2008 Background Wnt proteins comprise a large class of signaling molecules that regulate a variety of developmental processes, including synapse formation. Previous studies have shown Wnts to be involved in both the induction and prevention of synapses in a ...
Elizabeth K Davis +2 more
core +1 more source
The recent progress of peptide regulators for the Wnt/β-catenin signaling pathway
Frontiers in Medicine, 2023 Wnt signaling plays an important role in many biological processes such as stem cell self-renewal, cell proliferation, migration, and differentiation.
Nan Zhang +6 more
doaj +1 more source
Making sense of Wnt signaling—linking hair cell regeneration to development [PDF]
, 2015 Wnt signaling is a highly conserved pathway crucial for development and homeostasis of multicellular organisms. Secreted Wnt ligands bind Frizzled receptors to regulate diverse processes such as axis patterning, cell division, and cell fate specification.
Alan G. Cheng +2 more
core +2 more sources
Wnt Signaling in Neural Crest Ontogenesis and Oncogenesis. [PDF]
, 2019 Neural crest (NC) cells are a temporary population of multipotent stem cells that generate a diverse array of cell types, including craniofacial bone and cartilage, smooth muscle cells, melanocytes, and peripheral neurons and glia during embryonic ...
Hao, Hongyan +4 more
core +2 more sources
Wnt Signaling in Hepatocellular Carcinoma: Biological Mechanisms and Therapeutic Opportunities
CellsHepatocellular carcinoma (HCC), characterized by significant morbidity and mortality rates, poses a substantial threat to human health. The expression of ligands and receptors within the classical and non-classical Wnt signaling pathways plays an ...
Yingying Zhu, Yajing He, Runliang Gan
doaj +1 more source
TMEM132A, a Novel Wnt Signaling Pathway Regulator Through Wntless (WLS) Interaction
Frontiers in Cell and Developmental Biology, 2020 Wnt signaling pathway plays indispensable roles in embryonic development and adult tissue homeostasis. However, the regulatory mechanisms involved in Wnt ligand trafficking within and secretion from the signal sending cells is still relatively ...
Binbin Li, Lee A. Niswander
doaj +1 more source
Inhibition of Oncogenic Wnt Signaling through Direct Targeting of β-Catenin [PDF]
, 2014 Aberrant activation of signaling by the Wnt pathway is strongly implicated in the onset and progression of numerous types of cancer. Owing to the persistent dependence of these tumors on Wnt signaling for growth and survival, inhibition of this pathway ...
Bowman, Brian R. +5 more
core +1 more source