Results 11 to 20 of about 200,393 (308)
Progress of Wnt Signaling Pathway in Osteoporosis
Biomolecules, 2023 Osteoporosis, one of the serious health diseases, involves bone mass loss, bone density diminishing, and degeneration of bone microstructure, which is accompanied by a tendency toward bone fragility and a predisposition to fracture. More than 200 million
Yongguang Gao +3 more
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The Wnt signaling pathway in cancer [PDF]
Critical Reviews in Oncology/Hematology, 2016 The Wnt signaling pathway is critically involved in both the development and homeostasis of tissues via regulation of their endogenous stem cells. Aberrant Wnt signaling has been described as a key player in the initiation of and/or maintenance and development of many cancers, via affecting the behavior of Cancer Stem Cells (CSCs).
Yong－Mi Kim, Michael Kahn
exaly +3 more sources
Wnt and the Wnt signaling pathway in bone development and disease [PDF]
Frontiers in Bioscience - Landmark, 2014 Wnt signaling affects both bone modeling, which occurs during development, and bone remodeling, which is a lifelong process involving tissue renewal. Wnt signals are especially known to affect the differentiation of osteoblasts. In this review, we summarize recent advances in understanding the mechanisms of Wnt signaling, which is divided into two ...
Yi-Ping Li +2 more
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TMEM132A, a Novel Wnt Signaling Pathway Regulator Through Wntless (WLS) Interaction
Frontiers in Cell and Developmental Biology, 2020 Wnt signaling pathway plays indispensable roles in embryonic development and adult tissue homeostasis. However, the regulatory mechanisms involved in Wnt ligand trafficking within and secretion from the signal sending cells is still relatively ...
Binbin Li, Lee A. Niswander
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Wnt Signaling Pathway in Tumor Biology. [PDF]
Genes (Basel)Relapse and metastasis are the major challenges that stand in the way of cancer healing and survival, mainly attributed to cancer stem cells (CSCs). Their capabilities of self-renewal and tumorigenic potential leads to treatment resistance development. CSCs function through signaling pathways such as the Wnt/β-catenin cascade.
Iluta S, Nistor M, Buruiana S, Dima D.
europepmc +3 more sources
Wnt Signaling in Hepatocellular Carcinoma: Biological Mechanisms and Therapeutic Opportunities
CellsHepatocellular carcinoma (HCC), characterized by significant morbidity and mortality rates, poses a substantial threat to human health. The expression of ligands and receptors within the classical and non-classical Wnt signaling pathways plays an ...
Yingying Zhu, Yajing He, Runliang Gan
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Wnt signaling pathway in retinal vascularization
Eye and Brain, 2016 Wnt-signaling, a ubiquitous pathway that directs differentiation, cell polarity, and tissue specificity, has been implicated as an important gene-expression pathway in retinal development. An increasing body of evidence supports the importance of Wnt-signaling, and specifically, norrin-mediated Wnt-signaling in retinal development and retinal ...
Drenser KA
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Wnt signaling in colorectal cancer: pathogenic role and therapeutic target
Molecular Cancer, 2022 Background The Wnt signaling pathway is a complex network of protein interactions that functions most commonly in embryonic development and cancer, but is also involved in normal physiological processes in adults.
Hui Zhao +7 more
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The Wnt signalling pathway [PDF]
Journal of Cell Science, 2002 Recent advances in the field require an update of our Wnt pathway scheme ( [Hulsken and Behrens, 2000][1]). Intracellular signaling of the Wnt pathway diversifies into at least three branches: (1) the β-catenin pathway (canonical Wnt pathway, blue), which activates target genes in the nucleus ...
Joerg, Huelsken, Juergen, Behrens
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Aquaculture Reports, 2023 We previously found that squalene may influence immunity of grouper by affecting the Wnt/β-Catenin signaling pathway, but the exact mechanism is uncertain.
Xiaobo Yan +8 more
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