Results 11 to 20 of about 2,032,739 (298)
Wnt signaling pathway in retinal vascularization
Eye and Brain, 2016 Kimberly A Drenser Associated Retinal Consultants, Royal Oak, MI, USA Abstract: Wnt-signaling, a ubiquitous pathway that directs differentiation, cell polarity, and tissue specificity, has been implicated as an important gene-expression pathway in ...
Drenser KA
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The Wnt Signaling Pathway in Diabetic Nephropathy [PDF]
Frontiers in Cell and Developmental Biology, 2022 Diabetic nephropathy (DN) is a serious kidney-related complication of both type 1 and type 2 diabetes mellitus (T1DM, T2DM) and the second major cause of end-stage kidney disease. DN can lead to hypertension, edema, and proteinuria. In some cases, DN can even progress to kidney failure, a life-threatening condition.
Haiying Wang +9 more
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The Wnt signalling pathway [PDF]
Journal of Cell Science, 2002 Recent advances in the field require an update of our Wnt pathway scheme ( [Hulsken and Behrens, 2000][1]). Intracellular signaling of the Wnt pathway diversifies into at least three branches: (1) the β-catenin pathway (canonical Wnt pathway, blue), which activates target genes in the nucleus ...
Huelsken, J., Behrens, J.
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Wnt signal transduction pathways [PDF]
Organogenesis, 2008 The Wnt signaling pathway is an ancient and evolutionarily conserved pathway that regulates crucial aspects of cell fate determination, cell migration, cell polarity, neural patterning and organogenesis during embryonic development. The Wnts are secreted glycoproteins and comprise a large family of nineteen proteins in humans hinting to a daunting ...
Yuko, Komiya, Raymond, Habas
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Wnt and the Wnt signaling pathway in bone development and disease [PDF]
Frontiers in Bioscience, 2014 Wnt signaling affects both bone modeling, which occurs during development, and bone remodeling, which is a lifelong process involving tissue renewal. Wnt signals are especially known to affect the differentiation of osteoblasts. In this review, we summarize recent advances in understanding the mechanisms of Wnt signaling, which is divided into two ...
Yiping, Wang +6 more
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Autophagy and the Wnt signaling pathway: A focus on Wnt/β-catenin signaling
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2021 Cellular homeostasis and adaptation to various environmental conditions are importantly regulated by the sophisticated mechanism of autophagy and its crosstalk with Wnt signaling and other developmental pathways. Both autophagy and Wnt signaling are involved in embryogenesis and differentiation. Autophagy is responsible for degradation and recycling of
Shahrokh, Lorzadeh +3 more
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Wnt/β-catenin signaling pathway in lung cancer
Medicine in Drug Discovery, 2022 The Wnt signaling pathway regulates cell proliferation, differentiation, migration, genetic stability, and apoptosis in almost all tissues and organs. It plays a crucial role in the normal development of embryos and the dynamic balance of adult tissues ...
Wenhua Zhu, Heng Wang, Di Zhu
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An update on Wnt signaling pathway in cancer [PDF]
Translational Cancer Research, 2020 Wnt signaling involves many aspects of development, cell biology and physiology. Mutations in the Wnt gene can lead to abnormal embryonic development and cancer formation, including various aspects that affect proliferation, morphogenesis, and differentiation. The occurrence and development of tumors is a complex process involving multiple factors. The
Zhang, Yanlu +3 more
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Reporter gene HEK 293 cells and WNT/Frizzled fusion proteins as tools to study WNT signaling pathways [PDF]
, 2011 WNT/Frizzled receptor (FZD) signaling pathways are pivotal for physiological and pathophysiological processes. In humans, the complexity of WNT/FZD signaling is based on 19 WNTs, 10 FZDs and at least two (co)receptors (LRP5/6) mediating supposably four ...
Marisa Karow, +17 more
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Role of the Wnt signaling molecules in the tooth
Japanese Dental Science Review, 2016 Wnt signaling plays a central role in many processes during embryonic development and adult homeostasis. At least 19 types of Wnt ligands, receptors, transducers, transcription factors, and antagonists have been identified in mammals.
Masato Tamura, PhD, DDS +1 more
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