Results 21 to 30 of about 4,340,608 (283)
The role of primary cilia and sonic hedgehog signalling in adrenal development function. [PDF]
, 2012 PhDPrimary cilia are sensory organelles found on most vertebrate cells during interphase. They play key roles in development, cell signalling and cancer, and are involved in signal transduction pathways such as Hh and Wnt signalling.
Cogger, Kathryn
core +4 more sources
Vaping in Asthmatic Adolescents: Time to Deal with the Elephant in the Room
Children, 2022 Adolescence is a period characterized by developmental, psychological, and psychosocial alterations, with a major impact on youths’ attitudes and perceptions.
Grigorios Chatziparasidis, Ahmad Kantar
doaj +1 more source
Recent advances in primary cilia in bone metabolism
Frontiers in Endocrinology, 2023 Primary cilia are microtubule-based organelles that are widespread on the cell surface and play a key role in tissue development and homeostasis by sensing and transducing various signaling pathways.
Fenfen Lian +4 more
doaj +1 more source
Diverged morphology changes of astrocytic and neuronal primary cilia under reactive insults
Molecular Brain, 2020 Primary cilia are centriole-derived sensory organelles that are present in most mammalian cells, including astrocytes and neurons. Evidence is emerging that astrocyte and neuronal primary cilia demonstrate a dichotomy in the mature mouse brain.
Ashley Sterpka +5 more
doaj +1 more source
Primary Cilia Dysfunction in Neurodevelopmental Disorders beyond Ciliopathies
Journal of Developmental Biology, 2022 Primary cilia are specialized, microtubule-based structures projecting from the surface of most mammalian cells. These organelles are thought to primarily act as signaling hubs and sensors, receiving and integrating extracellular cues.
Vasiliki Karalis +2 more
doaj +1 more source
Calcium channels in primary cilia [PDF]
Current Opinion in Nephrology and Hypertension, 2016 Primary cilia have become important organelles implicated in embryonic development, organogenesis, health, and diseases. Although many studies in cell biology have focused on changes in ciliary length or ciliogenesis, the most common readout for evaluating ciliary function is intracellular calcium.Recent tools have allowed us to examine intracellular ...
Surya M, Nauli +2 more
openaire +2 more sources
Primary cilia: a novel research approach to overcome anticancer drug resistance
Frontiers in Molecular Biosciences, 2023 Primary cilia are cellular organelles that consist of a microtubule skeleton surrounded by a membrane filled with cell signaling receptors. Many studies have shown that primary cilia are cellular antennas, which serve as signaling hubs and their assembly
Kyung Ho Lee, Kyung Ho Lee
doaj +1 more source
Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium. [PDF]
, 2013 BACKGROUND: The primary cilium coordinates signalling in development, health and disease. Previously we have shown that the cilium is essential for the anabolic response to loading and the inflammatory response to interleukin-1β (IL-1β).
Wann, AK +7 more
core +1 more source
Role of Primary Cilia in Odontogenesis [PDF]
Journal of Dental Research, 2017 Primary cilium is a solitary organelle that emanates from the surface of most postmitotic mammalian cells and serves as a sensory organelle, transmitting the mechanical and chemical cues to the cell. Primary cilia are key coordinators of various signaling pathways during development and maintenance of tissue homeostasis.
M, Hampl +6 more
openaire +2 more sources
Heat shock induces rapid resorption of primary cilia [PDF]
, 2012 Primary cilia are involved in important developmental and disease pathways, such as the regulation of neurogenesis and tumorigenesis. They function as sensory antennae and are essential in the regulation of key extracellular signalling systems.
Ashworth, R +7 more
core +1 more source