Results 21 to 30 of about 37,275 (255)

Primary cilia in neurodevelopmental disorders [PDF]

Nature Reviews Neurology, 2013
Primary cilia are generally solitary organelles that emanate from the surface of almost all vertebrate cell types. Until recently, details regarding the function of these structures were lacking; however, extensive evidence now suggests that primary cilia have critical roles in sensing the extracellular environment, and in coordinating developmental ...
VALENTE, Enza Maria, R. O. Rosti, E. Gibbs, J. G. Gleeson   +3 more
openaire   +4 more sources

Diverged morphology changes of astrocytic and neuronal primary cilia under reactive insults

Molecular Brain, 2020
Primary cilia are centriole-derived sensory organelles that are present in most mammalian cells, including astrocytes and neurons. Evidence is emerging that astrocyte and neuronal primary cilia demonstrate a dichotomy in the mature mouse brain.
Ashley Sterpka, Juan Yang, Matthew Strobel, Yuxin Zhou, Connor Pauplis, Xuanmao Chen   +5 more
doaj   +1 more source

Alteration of primary cilia in COPD [PDF]

European Respiratory Journal, 2018
Non-differentiated airway epithelial cells display primary cilia and their number is associated with COPD featureshttp://ow.ly ...
Perotin, Jeanne-Marie, Coraux, Christelle, Lagonotte, Eymeric, Birembaut, Philippe, Delepine, Gonzague, Polette, Myriam, Deslée, Gaetan, Dormoy, Valérian   +7 more
openaire   +4 more sources

Primary Cilia Dysfunction in Neurodevelopmental Disorders beyond Ciliopathies

Journal of Developmental Biology, 2022
Primary cilia are specialized, microtubule-based structures projecting from the surface of most mammalian cells. These organelles are thought to primarily act as signaling hubs and sensors, receiving and integrating extracellular cues.
Vasiliki Karalis, Kathleen E. Donovan, Mustafa Sahin   +2 more
doaj   +1 more source

Primary cilia: a novel research approach to overcome anticancer drug resistance

Frontiers in Molecular Biosciences, 2023
Primary cilia are cellular organelles that consist of a microtubule skeleton surrounded by a membrane filled with cell signaling receptors. Many studies have shown that primary cilia are cellular antennas, which serve as signaling hubs and their assembly
Kyung Ho Lee, Kyung Ho Lee
doaj   +1 more source

Calcium channels in primary cilia [PDF]

Current Opinion in Nephrology and Hypertension, 2016
Primary cilia have become important organelles implicated in embryonic development, organogenesis, health, and diseases. Although many studies in cell biology have focused on changes in ciliary length or ciliogenesis, the most common readout for evaluating ciliary function is intracellular calcium.Recent tools have allowed us to examine intracellular ...
Surya M, Nauli, Rajasekharreddy, Pala, Steven J, Kleene   +2 more
openaire   +2 more sources

Primary cilia and their role in preeclampsia. [PDF]

Int J Med Sci
Preeclampsia is a hypertensive disorder of pregnancy characterized by chronic placental ischemia and systemic maternal organ damage. The placenta is rich in blood vessels containing various types of cells, and preeclampsia is now widely accepted as a placenta-derived disease. Although the primary cilium regulates many diseases, its role in preeclampsia
Liao L, Zhou R, Liu M.
europepmc   +4 more sources

Kinesin motors and primary cilia [PDF]

Biochemical Society Transactions, 2011
Cilia and flagella play important roles in human health by contributing to cellular motility as well as sensing and responding to environmental cues. Defects in ciliary assembly and/or function can lead to a range of human diseases, collectively known as the ciliopathies, including polycystic kidney, liver and pancreatic diseases, sterility, obesity ...
Kristen J, Verhey, John, Dishinger, Hooi Lynn, Kee   +2 more
openaire   +2 more sources

A Flow Cytometry-Based Approach for the Isolation and Characterization of Neural Stem Cell Primary Cilia

Frontiers in Cellular Neuroscience, 2019
In the adult mammalian brain, the apical surface of the subependymal zone (SEZ) is covered by many motile ependymal cilia and a few primary cilia originating from rare intermingled neural stem cells (NSCs).
Sara Monaco, Katja Baur, Andrea Hellwig, Gabriele Hölzl-Wenig, Claudia Mandl, Francesca Ciccolini   +5 more
doaj   +1 more source

INPP5E and Coordination of Signaling Networks in Cilia

Frontiers in Molecular Biosciences, 2022
Primary cilia are ubiquitous mechanosensory organelles that specifically coordinate a series of cellular signal transduction pathways to control cellular physiological processes during development and in tissue homeostasis.
Renshuai Zhang, Jianming Tang, Tianliang Li, Jun Zhou, Wei Pan   +4 more
doaj   +1 more source