Results 41 to 50 of about 4,340,608 (283)
Kinesin motors and primary cilia [PDF]
Biochemical Society Transactions, 2011 Cilia and flagella play important roles in human health by contributing to cellular motility as well as sensing and responding to environmental cues. Defects in ciliary assembly and/or function can lead to a range of human diseases, collectively known as the ciliopathies, including polycystic kidney, liver and pancreatic diseases, sterility, obesity ...
Kristen J, Verhey +2 more
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Ionizing radiation promotes primary ciliogenesis in glioblastoma cells
Fushe yanjiu yu fushe gongyi xuebao, 2021 The aim of this study was to investigate the effects of ionizing radiation (IR) on ciliogenesis of human glioblastoma cells. The glioblastoma cell lines M059K and M059J were exposed to X-ray or carbon ion at different doses, and the incidence and length ...
MA Wei +5 more
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Bardet-Biedl syndrome proteins control cilia length through regulation of actin polymerisation. [PDF]
, 2012 Primary cilia are cellular appendages important for signal transduction and sensing the environment. Bardet-Biedl syndrome proteins form a complex that is important for several cytoskeleton-related processes such as ciliogenesis, cell migration and ...
D Jenkins +20 more
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Primary cilia are lost in preinvasive and invasive prostate cancer. [PDF]
PLoS ONE, 2013 Prostate cancer is the second most commonly diagnosed cancer in men worldwide. Little is known about the role of primary cilia in preinvasive and invasive prostate cancer.
Nadia B Hassounah +5 more
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The emerging face of primary cilia [PDF]
genesis, 2011 AbstractPrimary cilia are microtubule‐based organelles that serve as hubs for the transduction of various developmental signaling pathways includingHedgehog, Wnt, FGF, and PDGF. Ciliary dysfunction contributes to a range of disorders, collectively known as the ciliopathies.
Norann A, Zaghloul, Samantha A, Brugmann
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口腔疾病防治, 2020 Primary cilia are organelles present on most mammalian cells that sense environmental changes and transduce signaling, and they are the key coordinators of various signaling pathways during tissue development.
ZHOU Tao +4 more
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Alteration of primary cilia and intraflagellar transport 20 (IFT20) expression in oral squamous cell carcinoma (OSCC) cell lines [PDF]
PeerJBackground Aberrations in primary cilia expression and intraflagellar transport (IFT) protein function have been implicated in tumourigenesis.
Gulam Sakinah-Syed +3 more
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Primary cilia are not calcium-responsive mechanosensors [PDF]
Nature, 2016 Primary cilia are solitary, generally non-motile, hair-like protrusions that extend from the surface of cells between cell divisions. Their antenna-like structure leads naturally to the assumption that they sense the surrounding environment, the most common hypothesis being sensation of mechanical force through calcium-permeable ion channels within the
Delling, M. +6 more
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Primary cilia and forebrain development
Mechanisms of Development, 2013 With a microtubule-based axoneme supporting its plasma membrane-ensheathed projection from the basal body of almost all cell types in the human body, and present in only one copy per cell, the primary cilium can be considered an organelle sui generis.
Willaredt, Marc August +2 more
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Renal epithelial cells retain primary cilia during human acute renal allograft rejection injury
BMC Research Notes, 2019 Objectives Primary cilia are sensory organelles which co-ordinate several developmental/repair pathways including hedgehog signalling. Studies of human renal allografts suffering acute tubular necrosis have shown that length of primary cilia borne by ...
Elizabeth Verghese +9 more
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