Results 41 to 50 of about 42,278 (249)

Alteration of primary cilia and intraflagellar transport 20 (IFT20) expression in oral squamous cell carcinoma (OSCC) cell lines [PDF]

PeerJ
Background Aberrations in primary cilia expression and intraflagellar transport (IFT) protein function have been implicated in tumourigenesis.
Gulam Sakinah-Syed, Jia Shi Liew, Nazia Abdul Majid, Siti Amalina Inche Zainal Abidin   +3 more
doaj   +2 more sources

Tau tubulin kinase 1 and 2 regulate ciliogenesis and human pluripotent stem cells–derived neural rosettes

Scientific Reports, 2023
Primary cilia are key regulators of embryo development and tissue homeostasis. However, their mechanisms and functions, particularly in the context of human cells, are still unclear.
Lucia Binó, Lukáš Čajánek
doaj   +1 more source

Basal body stability and ciliogenesis requires the conserved component Poc1 [PDF]

, 2009
Centrioles are the foundation for centrosome and cilia formation. The biogenesis of centrioles is initiated by an assembly mechanism that first synthesizes the ninefold symmetrical cartwheel and subsequently leads to a stable cylindrical microtubule ...
Thomas H. Giddings, Mark Winey, Osborn, DP, Chad G. Pearson, Philip L. Beales, Beales, PL, Giddings, TH, Winey, M, Pearson, CG, Daniel P.S. Osborn   +9 more
core   +1 more source

Renal epithelial cells retain primary cilia during human acute renal allograft rejection injury

BMC Research Notes, 2019
Objectives Primary cilia are sensory organelles which co-ordinate several developmental/repair pathways including hedgehog signalling. Studies of human renal allografts suffering acute tubular necrosis have shown that length of primary cilia borne by ...
Elizabeth Verghese, Luciano G. Martelotto, Jason E. Cain, Timothy M. Williams, Andrea F. Wise, Prudence A. Hill, Robyn G. Langham, D. Neil Watkins, Sharon D. Ricardo, James A. Deane   +9 more
doaj   +1 more source

An inducible CiliaGFP mouse model for in vivo visualization and analysis of cilia in live tissue [PDF]

, 2013
BackgroundCilia are found on nearly every cell type in the mammalian body, and have been historically classified as either motile or immotile. Motile cilia are important for fluid and cellular movement; however, the roles of non-motile or primary cilia ...
Mandy J Croyle, Erik B Malarkey, Nicolas F Berbari, Croyle, Mandy J., Robert A Kesterson, Croyle, Mandy J, Malarkey, Erik B., O’Connor, Amber K., Yoder, Bradley K., Yoder, Bradley K, Bell, P Darwin, Amber K O’Connor, Haycraft, Courtney J., Peter Hohenstein, Berbari, Nicolas F., Kesterson, Robert A., Haycraft, Courtney J, P Darwin Bell, Bradley K Yoder, Hohenstein, Peter, Bell, P. Darwin, Malarkey, Erik B, Courtney J Haycraft, Berbari, Nicolas F, Kesterson, Robert A, O’connor, Amber K   +25 more
core   +1 more source

Primary cilia regulate adaptive responses to fasting [PDF]

, 2022
Objective: Neuronal primary cilia are known to be a required organelle for energy balance and leptin action. However, whether primary cilia directly mediate adaptive responses during starvation is yet unknown.
신동민, 김기우, 최윤희
core   +2 more sources

Mechanical Properties of Isolated Primary Cilia Measured by Micro-tensile Test and Atomic Force Microscopy

Frontiers in Bioengineering and Biotechnology, 2021
Mechanotransduction is a well-known mechanism by which cells sense their surrounding mechanical environment, convert mechanical stimuli into biochemical signals, and eventually change their morphology and functions.
Tien-Dung Do, Jimuro Katsuyoshi, Haonai Cai, Toshiro Ohashi   +3 more
doaj   +1 more source

Loss of FTO Antagonises Wnt Signaling and Leads to Developmental Defects Associated with Ciliopathies [PDF]

, 2014
Common intronic variants in the Human fat mass and obesity-associated gene (FTO) are found to be associated with an increased risk of obesity. Overexpression of FTO correlates with increased food intake and obesity, whilst loss-of-function results in ...
Rosa Maria Roccasecca (519728), Osborn Daniel P. S., Beales, PL, Daniel P. S. Osborn (519727), Fiona McMurray, Derek Stemple (183414), McMurray, F, Stemple Derek, Roccasecca, RM, Barroso, I, Philip L. Beales (492737), Osborn, DP, Inês Barroso (2144), Hernandez-Hernandez, V, Mukherjee, S, Derek Stemple, Cox, R, Philip L Beales, Victor Hernandez-Hernandez, Stemple, D, Sonia Christou-Savina (519731), Christou-Savina, S, Barroso Inês, Sriparna Mukherjee, Mukherjee Sriparna, Roccasecca Rosa Maria, Cox Roger, Sonia Christou-Savina, Hernandez-Hernandez Victor, Victor Hernandez-Hernandez (519729), Fiona McMurray (106290), Rosa Maria Roccasecca, Sriparna Mukherjee (519730), Beales Philip L., Daniel P S Osborn, Inês Barroso, McMurray Fiona, Osborn, DPS, Roger Cox, Christou-Savina Sonia, Roger Cox (73899)   +40 more
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Primary Cilia Are Critical Regulators of White Adipose Tissue Expansion

Frontiers in Physiology, 2021
The primary cilium is a microtubule-based cellular protrusion found on most mammalian cell types in diverse tissues. It functions as a cellular antenna to sense and transduce a broad range of signals, including odorants, light, mechanical stimuli, and ...
Keren I. Hilgendorf
doaj   +1 more source