Results 31 to 40 of about 4,340,608 (283)

Depletion of chondrocyte primary cilia reduces the compressive modulus of articular cartilage [PDF]

, 2014
Primary cilia are slender, microtubule based structures found in the majority of cell types with one cilium per cell. In articular cartilage, primary cilia are required for chondrocyte mechanotransduction and the development of healthy tissue.
Ramaswamy, G, Ramaswamy, Girish, Irianto, J, Serra, Rosa, Knight, MM, Knight, Martin M., Serra, R, Irianto, Jerome   +7 more
core   +1 more source

Primary cilia in neurodevelopmental disorders [PDF]

Nature Reviews Neurology, 2013
Primary cilia are generally solitary organelles that emanate from the surface of almost all vertebrate cell types. Until recently, details regarding the function of these structures were lacking; however, extensive evidence now suggests that primary cilia have critical roles in sensing the extracellular environment, and in coordinating developmental ...
VALENTE, Enza Maria, R. O. Rosti, E. Gibbs, J. G. Gleeson   +3 more
openaire   +4 more sources

A Flow Cytometry-Based Approach for the Isolation and Characterization of Neural Stem Cell Primary Cilia

Frontiers in Cellular Neuroscience, 2019
In the adult mammalian brain, the apical surface of the subependymal zone (SEZ) is covered by many motile ependymal cilia and a few primary cilia originating from rare intermingled neural stem cells (NSCs).
Sara Monaco, Katja Baur, Andrea Hellwig, Gabriele Hölzl-Wenig, Claudia Mandl, Francesca Ciccolini   +5 more
doaj   +1 more source

INPP5E and Coordination of Signaling Networks in Cilia

Frontiers in Molecular Biosciences, 2022
Primary cilia are ubiquitous mechanosensory organelles that specifically coordinate a series of cellular signal transduction pathways to control cellular physiological processes during development and in tissue homeostasis.
Renshuai Zhang, Jianming Tang, Tianliang Li, Jun Zhou, Wei Pan   +4 more
doaj   +1 more source

Primary cilia elongation in response to interleukin-1 mediates the inflammatory response [PDF]

, 2012
Primary cilia are singular, cytoskeletal organelles present in the majority of mammalian cell types where they function as coordinating centres for mechanotransduction, Wnt and hedgehog signalling. The length of the primary cilium is proposed to modulate
Knight, M.M., A. K. T. Wann, Wann, A.K.T., Knight, MM, Wann, AKT, M. M. Knight   +5 more
core   +1 more source

Primary cilia and their role in preeclampsia. [PDF]

Int J Med Sci
Preeclampsia is a hypertensive disorder of pregnancy characterized by chronic placental ischemia and systemic maternal organ damage. The placenta is rich in blood vessels containing various types of cells, and preeclampsia is now widely accepted as a placenta-derived disease. Although the primary cilium regulates many diseases, its role in preeclampsia
Liao L, Zhou R, Liu M.
europepmc   +4 more sources

Alteration of primary cilia in COPD [PDF]

European Respiratory Journal, 2018
Non-differentiated airway epithelial cells display primary cilia and their number is associated with COPD featureshttp://ow.ly ...
Perotin, Jeanne-Marie, Coraux, Christelle, Lagonotte, Eymeric, Birembaut, Philippe, Delepine, Gonzague, Polette, Myriam, Deslée, Gaetan, Dormoy, Valérian   +7 more
openaire   +4 more sources

Targeting of vasoactive intestinal peptide receptor 2, VPAC2, a secretin family G-protein coupled receptor, to primary cilia

Biology Open, 2013
Summary Primary cilia protrude from the cell surface of many cell types in the human body and function as cellular antennae via ciliary membrane localized receptors.
Livana Soetedjo, De'Vona A. Glover, Hua Jin   +2 more
doaj   +1 more source

Primary Cilia and the Cell Cycle [PDF]

, 2009
Cilia are microtubule-based structures that protrude from the cell surface and function as sensors for mechanical and chemical environmental cues that regulate cellular differentiation or division. In metazoans, ciliary signaling is important during organismal development and in the homeostasis controls of adult tissues, with receptors for the Hedgehog,
Olga V, Plotnikova, Elena N, Pugacheva, Erica A, Golemis   +2 more
openaire   +2 more sources

Primary Cilia in Glial Cells: An Oasis in the Journey to Overcoming Neurodegenerative Diseases

Frontiers in Neuroscience, 2021
Many neurodegenerative diseases have been associated with defects in primary cilia, which are cellular organelles involved in diverse cellular processes and homeostasis.
Soo Mi Ki, Hui Su Jeong, Ji Eun Lee, Ji Eun Lee   +3 more
doaj   +1 more source