Results 31 to 40 of about 4,554,367 (185)

Role of Primary Cilia in Odontogenesis [PDF]

Journal of Dental Research, 2017
Primary cilium is a solitary organelle that emanates from the surface of most postmitotic mammalian cells and serves as a sensory organelle, transmitting the mechanical and chemical cues to the cell. Primary cilia are key coordinators of various signaling pathways during development and maintenance of tissue homeostasis.
M, Hampl, P, Cela, H L, Szabo-Rogers, M, Kunova Bosakova, H, Dosedelova, P, Krejci, M, Buchtova   +6 more
openaire   +2 more sources

Heat shock induces rapid resorption of primary cilia [PDF]

, 2012
Primary cilia are involved in important developmental and disease pathways, such as the regulation of neurogenesis and tumorigenesis. They function as sensory antennae and are essential in the regulation of key extracellular signalling systems.
Ashworth, R, Prodromou, NV, Osborn, DP, Chapple, JP, Beales, PL, Knight, MM, Thompson, CL, Cogger, KF   +7 more
core   +1 more source

Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium. [PDF]

, 2013
BACKGROUND: The primary cilium coordinates signalling in development, health and disease. Previously we have shown that the cilium is essential for the anabolic response to loading and the inflammatory response to interleukin-1β (IL-1β).
Wann, AK, Wann, Angus K.T., Chapple, JP, Knight, MM, Knight, Martin M., Thompson, CL, Thompson, Clare L., Chapple, J. Paul   +7 more
core   +1 more source

Primary cilia in neurodevelopmental disorders [PDF]

Nature Reviews Neurology, 2013
Primary cilia are generally solitary organelles that emanate from the surface of almost all vertebrate cell types. Until recently, details regarding the function of these structures were lacking; however, extensive evidence now suggests that primary cilia have critical roles in sensing the extracellular environment, and in coordinating developmental ...
VALENTE, Enza Maria, R. O. Rosti, E. Gibbs, J. G. Gleeson   +3 more
openaire   +4 more sources

A Flow Cytometry-Based Approach for the Isolation and Characterization of Neural Stem Cell Primary Cilia

Frontiers in Cellular Neuroscience, 2019
In the adult mammalian brain, the apical surface of the subependymal zone (SEZ) is covered by many motile ependymal cilia and a few primary cilia originating from rare intermingled neural stem cells (NSCs).
Sara Monaco, Katja Baur, Andrea Hellwig, Gabriele Hölzl-Wenig, Claudia Mandl, Francesca Ciccolini   +5 more
doaj   +1 more source

INPP5E and Coordination of Signaling Networks in Cilia

Frontiers in Molecular Biosciences, 2022
Primary cilia are ubiquitous mechanosensory organelles that specifically coordinate a series of cellular signal transduction pathways to control cellular physiological processes during development and in tissue homeostasis.
Renshuai Zhang, Jianming Tang, Tianliang Li, Jun Zhou, Wei Pan   +4 more
doaj   +1 more source

Depletion of chondrocyte primary cilia reduces the compressive modulus of articular cartilage [PDF]

, 2014
Primary cilia are slender, microtubule based structures found in the majority of cell types with one cilium per cell. In articular cartilage, primary cilia are required for chondrocyte mechanotransduction and the development of healthy tissue.
Ramaswamy, G, Irianto, J, Knight, MM, Serra, R   +3 more
core   +1 more source

Primary cilia and their role in preeclampsia. [PDF]

Int J Med Sci
Preeclampsia is a hypertensive disorder of pregnancy characterized by chronic placental ischemia and systemic maternal organ damage. The placenta is rich in blood vessels containing various types of cells, and preeclampsia is now widely accepted as a placenta-derived disease. Although the primary cilium regulates many diseases, its role in preeclampsia
Liao L, Zhou R, Liu M.
europepmc   +4 more sources

Alteration of primary cilia in COPD [PDF]

European Respiratory Journal, 2018
Non-differentiated airway epithelial cells display primary cilia and their number is associated with COPD featureshttp://ow.ly ...
Perotin, Jeanne-Marie, Coraux, Christelle, Lagonotte, Eymeric, Birembaut, Philippe, Delepine, Gonzague, Polette, Myriam, Deslée, Gaetan, Dormoy, Valérian   +7 more
openaire   +4 more sources

Targeting of vasoactive intestinal peptide receptor 2, VPAC2, a secretin family G-protein coupled receptor, to primary cilia

Biology Open, 2013
Summary Primary cilia protrude from the cell surface of many cell types in the human body and function as cellular antennae via ciliary membrane localized receptors.
Livana Soetedjo, De'Vona A. Glover, Hua Jin   +2 more
doaj   +1 more source