Results 31 to 40 of about 76,105 (304)

INPP5E and Coordination of Signaling Networks in Cilia

Frontiers in Molecular Biosciences, 2022
Primary cilia are ubiquitous mechanosensory organelles that specifically coordinate a series of cellular signal transduction pathways to control cellular physiological processes during development and in tissue homeostasis.
Renshuai Zhang, Jianming Tang, Tianliang Li, Jun Zhou, Wei Pan   +4 more
doaj   +1 more source

A role for Tctex-1 (DYNLT1) in controlling primary cilium length [PDF]

, 2011
The microtubule motor complex cytoplasmic dynein is known to be involved in multiple processes including endomembrane organization and trafficking, mitosis, and microtubule organization.
MacCarthy-Morrogh, LJ, Miss Nicola, Smyllie, Palmer, KJ, Stephens, DJ   +3 more
core   +2 more sources

Endothelial primary cilia inhibit atherosclerosis [PDF]

EMBO reports, 2016
Primary cilia are microtubule-based structures present on most mammalian cells that are important for intercellular signaling. Cilia are present on a subset of endothelial cells where they project into the vessel lumen and are implicated as mechanical sensors of blood flow.
Dinsmore, Colin, Reiter, Jeremy F
openaire   +4 more sources

Hedgehog Pathway Activation Alters Ciliary Signaling in Primary Hypothalamic Cultures [PDF]

, 2019
Primary cilia dysfunction has been associated with hyperphagia and obesity in both ciliopathy patients and mouse models of cilia perturbation. Neurons throughout the brain possess these solitary cellular appendages, including in the feeding centers of ...
Antonellis, Patrick J., Bansal, Ruchi, Baucum, Anthony J., Berbari, Nicolas F., Cummins, Theodore R., Engle, Staci E., Reiter, Jeremy F., Whitehouse, Logan S.   +7 more
core   +1 more source

Kinesin motors and primary cilia [PDF]

Biochemical Society Transactions, 2011
Cilia and flagella play important roles in human health by contributing to cellular motility as well as sensing and responding to environmental cues. Defects in ciliary assembly and/or function can lead to a range of human diseases, collectively known as the ciliopathies, including polycystic kidney, liver and pancreatic diseases, sterility, obesity ...
Kristen J, Verhey, John, Dishinger, Hooi Lynn, Kee   +2 more
openaire   +2 more sources

Targeting of vasoactive intestinal peptide receptor 2, VPAC2, a secretin family G-protein coupled receptor, to primary cilia

Biology Open, 2013
Summary Primary cilia protrude from the cell surface of many cell types in the human body and function as cellular antennae via ciliary membrane localized receptors.
Livana Soetedjo, De'Vona A. Glover, Hua Jin   +2 more
doaj   +1 more source

Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium. [PDF]

, 2013
BACKGROUND: The primary cilium coordinates signalling in development, health and disease. Previously we have shown that the cilium is essential for the anabolic response to loading and the inflammatory response to interleukin-1β (IL-1β).
AC Lin, AK Wann, AK Wann, AM Malone, AR Sartori-Cintra, BL Thoms, BL Thoms, CA Clement, CA Clement, CF Chang, CJ Haycraft, CJ Haycraft, CR Thoma, D Kong, D Zhu, DA Hoey, DM Katschinski, E Verghese, EN Pugacheva, F Oeffner, GJ Pazour, HA Praetorius, J Kim, JB Catterall, JC Kim, JE Bohonowych, JE Lafont, JF Reiter, JH Moyer, JH Ryu, JM Gerdes, JR Marszalek, JT Eggenschwiler, KC Corbit, KC Corbit, L Schneider, M Windheim, MA Lancaster, MF Bijlsma, NV Prodromou, P Jaakkola, PD Taulman, PV Tran, R Rohatgi, RD Thornton, S Abdul-Majeed, S Kim, S Massinen, S Murakami, S Proulx-Bonneau, S Yang, SH Low, SM Nauli, SN Greer, SR McGlashan, SR McGlashan, T Caspary, TY Besschetnova, X Xue, Y Li, YJ Jung   +60 more
core   +1 more source

Primary Cilia and Calcium Signaling Interactions [PDF]

International Journal of Molecular Sciences, 2020
The calcium ion (Ca2+) is a diverse secondary messenger with a near-ubiquitous role in a vast array of cellular processes. Cilia are present on nearly every cell type in either a motile or non-motile form; motile cilia generate fluid flow needed for a variety of biological processes, such as left–right body patterning during development, while non ...
Hannah Saternos, Sidney Ley, Wissam AbouAlaiwi   +2 more
openaire   +2 more sources

Visualization of Astrocytic Primary Cilia in the Mouse Brain by Immunofluorescent Analysis Using the Cilia Marker Arl13b [PDF]

, 2014
In vertebrates, almost all somatic cells extend a single immotile cilium, referred to as a primary cilium. Increasing evidence suggests that primary cilia serve as cellular antennae in many types of tissues by sensing chemical or mechanical stimuli in ...
Asanuma, Masato, Kasahara, Kyosuke, Miyazaki, Ikuko, Miyoshi, Ko, Murakami, Shinki   +4 more
core   +1 more source

Ionizing radiation promotes primary ciliogenesis in glioblastoma cells

Fushe yanjiu yu fushe gongyi xuebao, 2021
The aim of this study was to investigate the effects of ionizing radiation (IR) on ciliogenesis of human glioblastoma cells. The glioblastoma cell lines M059K and M059J were exposed to X-ray or carbon ion at different doses, and the incidence and length ...
MA Wei, MA Qinglong, WEI Li, HUA Junrui, HE Jinpeng, WANG Jufang   +5 more
doaj   +1 more source