Results 51 to 60 of about 42,278 (249)

Endothelial primary cilia inhibit atherosclerosis [PDF]

, 2016
Primary cilia are microtubule-based structures present on most mammalian cells that are important for intercellular signaling. Cilia are present on a subset of endothelial cells where they project into the vessel lumen and are implicated as mechanical ...
Dinsmore, Colin, Jeremy F Reiter, Colin Dinsmore, Reiter, Jeremy F   +3 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Characterization of astrocytic primary cilia in the adult mouse cortex and hippocampus

Heliyon
The primary cilium is a single, antenna-like projection found on the surface of eukaryotic cells. Primary cilia contain cell signaling components that are critical for developmental patterning and cell cycle maintenance.
Sylvie C. Lahaie, Albert HK. Fok, Jessica M. Nicholls, Hannah Lee, Tabish A. Syed, Sabrina Chierzi, Sayuri Hatada, Naomi Egawa, Alex L. Schober, Tak Yi Mayumi Wong, Robert Royston, Jr., Kaleem Siddiqi, Yoshiyuki Kubota, Keith K. Murai   +13 more
doaj   +1 more source

Primary Cilium Identifies a Quiescent Cell Population in the Human Intestinal Crypt

Cells, 2023
Primary cilia are sensory antennae located at the cell surface which mediate a variety of extracellular signals involved in development, tissue homeostasis, stem cells and cancer.
Blanche Sénicourt, Gabriel Cloutier, Nuria Basora, Sepideh Fallah, Andréanne Laniel, Christine Lavoie, Jean-François Beaulieu   +6 more
doaj   +1 more source

Primary ciliary dyskinesia: current state of the art

, 2007
Primary ciliary dyskinesia (PCD) is usually inherited as an autosomal recessive, and in classical form presents with upper and lower respiratory tract infection, and mirror image arrangement in around 50% cases.
Hall, Pippa, Collins, Nicola F., Hariri, Mohamed, Harcourt, Jonny, Chodhari, Rahul, Lucas, Jane, Phillips, Gill, Bush, Andrew, Copeland, Fiona, Hogg, Claire, O'Callaghan, Chriatopher   +10 more
core   +1 more source

Islet primary cilia motility controls insulin secretion

, 2022
Primary cilia are specialized cell-surface organelles that mediate sensory perception and, in contrast to motile cilia and flagella, are thought to lack motility function.
Hughes, Jing W., Bayly, Philip V., Bayly, Philip V, Li, Zipeng A., Hughes, Jing W, Zhu, Lifei, Woodhams, Louis G., Muegge, Brian D, Muegge, Brian D., Lee, Eun Young, Roseman, Henry F., Utterback, Toby, Roseman, Henry F, Cho, Jung Hoon, Woodhams, Louis G, Li, Zipeng A   +15 more
core   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Primary Cilia in the Skin: Functions in Immunity and Therapeutic Potential

Frontiers in Cell and Developmental Biology, 2021
The skin is the biggest organ and provides a physical and immunological barrier against pathogen infection. The distribution of primary cilia in the skin of mice has been reported, but which cells in human skin have them has not, and we still know very ...
Manami Toriyama, Manami Toriyama, Manami Toriyama, Ken J. Ishii, Ken J. Ishii, Ken J. Ishii   +5 more
doaj   +1 more source

Primary cilia utilize glycoprotein-dependent adhesion mechanisms to stabilize long-lasting cilia-cilia contacts [PDF]

, 2012
Background The central tenet of cilia function is sensing and transmitting information. The capacity to directly contact extracellular surfaces would empower primary cilia to probe the environment for information about the nature and location of nearby ...
Prabuddha Sengupta, Sengupta, Prabuddha, Carolyn Ott, Ott, Carolyn, Lippincott-Schwartz, Jennifer, Jennifer Lippincott-Schwartz, Insinna, Christine, Christine Insinna, Suh Jeong, Jeong, Suh, Elia, Natalie, Natalie Elia   +11 more
core   +1 more source

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source