Results 51 to 60 of about 4,340,608 (283)

Culture and detection of primary cilia in endothelial cell models [PDF]

, 2015
Background: The primary cilium is a sensor of blood-induced forces in endothelial cells (ECs). Studies that have examined EC primary cilia have reported a wide range of cilia incidence (percentage of ciliated cells). We hypothesise that this variation is
Cooling, Michael, Yi Chung Lim, Long, David, David S. Long, McGlashan, Susan, Sue R. McGlashan, Michael T. Cooling, Lim, Yi   +7 more
core   +1 more source

Tau tubulin kinase 1 and 2 regulate ciliogenesis and human pluripotent stem cells–derived neural rosettes

Scientific Reports, 2023
Primary cilia are key regulators of embryo development and tissue homeostasis. However, their mechanisms and functions, particularly in the context of human cells, are still unclear.
Lucia Binó, Lukáš Čajánek
doaj   +1 more source

Cep164, a novel centriole appendage protein required for primary cilium formation [PDF]

, 2007
Primary cilia (PC) function as microtubule-based sensory antennae projecting from the surface of many eukaryotic cells. They play important roles in mechano- and chemosensory perception and their dysfunction is implicated in developmental disorders and ...
Graser, Susanne, Erich A. Nigg, Gassner, Oliver S., Gassner, O. S., Susanne Graser, Stierhof, Y. D., Lavoie, S. B., Stierhof, York-Dieter, Nigg, E. A., Sébastien B. Lavoie, Le Clech, M., Stefan Lamla, Graser, S., Nigg, Erich A., Lavoie, Sébastien B., York-Dieter Stierhof, Le Clech, Mikael, Oliver S. Gassner, Mikael Le Clech, Lamla, S., Lamla, Stefan   +20 more
core   +1 more source

A Phosphoinositide Code for Primary Cilia [PDF]

Developmental Cell, 2015
How phosphoinositide metabolism is coupled to primary cilia physiology is poorly understood. Reporting recently in Developmental Cell, Chávez et al. (2015) and Garcia-Gonzalo et al. (2015) show that INPP5E-mediated phosphoinositide metabolism, which creates a specific phosphoinositide distribution, ensures proper protein trafficking and Hh signaling in
openaire   +2 more sources

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Mechanical Properties of Isolated Primary Cilia Measured by Micro-tensile Test and Atomic Force Microscopy

Frontiers in Bioengineering and Biotechnology, 2021
Mechanotransduction is a well-known mechanism by which cells sense their surrounding mechanical environment, convert mechanical stimuli into biochemical signals, and eventually change their morphology and functions.
Tien-Dung Do, Jimuro Katsuyoshi, Haonai Cai, Toshiro Ohashi   +3 more
doaj   +1 more source

Rab7 regulates primary cilia disassembly through cilia excision [PDF]

Journal of Cell Biology, 2019
The primary cilium is a sensory organelle that protrudes from the cell surface. Primary cilia undergo dynamic transitions between assembly and disassembly to exert their function in cell signaling. In this study, we identify the small GTPase Rab7 as a novel regulator of cilia disassembly.
Guang Wang, Huai-Bin Hu, Yan Chang, Yan Huang, Zeng-Qing Song, Shi-Bo Zhou, Liang Chen, Yu-Cheng Zhang, Min Wu, Hai-Qing Tu, Jin-Feng Yuan, Na Wang, Xin Pan, Ai-Ling Li, Tao Zhou, Xue-Min Zhang, Kun He, Hui-Yan Li   +17 more
openaire   +2 more sources

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Characterization of astrocytic primary cilia in the adult mouse cortex and hippocampus

Heliyon
The primary cilium is a single, antenna-like projection found on the surface of eukaryotic cells. Primary cilia contain cell signaling components that are critical for developmental patterning and cell cycle maintenance.
Sylvie C. Lahaie, Albert HK. Fok, Jessica M. Nicholls, Hannah Lee, Tabish A. Syed, Sabrina Chierzi, Sayuri Hatada, Naomi Egawa, Alex L. Schober, Tak Yi Mayumi Wong, Robert Royston, Jr., Kaleem Siddiqi, Yoshiyuki Kubota, Keith K. Murai   +13 more
doaj   +1 more source

Primary Cilia Are Critical Regulators of White Adipose Tissue Expansion

Frontiers in Physiology, 2021
The primary cilium is a microtubule-based cellular protrusion found on most mammalian cell types in diverse tissues. It functions as a cellular antenna to sense and transduce a broad range of signals, including odorants, light, mechanical stimuli, and ...
Keren I. Hilgendorf
doaj   +1 more source