Results 51 to 60 of about 76,105 (304)
Alteration of primary cilia and intraflagellar transport 20 (IFT20) expression in oral squamous cell carcinoma (OSCC) cell lines [PDF]
PeerJBackground Aberrations in primary cilia expression and intraflagellar transport (IFT) protein function have been implicated in tumourigenesis.
Gulam Sakinah-Syed +3 more
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Ccdc11 is a novel centriolar satellite protein essential for ciliogenesis and establishment of left-right asymmetry [PDF]
, 2016 The establishment of left–right (L-R) asymmetry in vertebrates is dependent on the sensory and motile functions of cilia during embryogenesis. Mutations in CCDC11 disrupt L-R asymmetry and cause congenital heart disease in humans, yet the molecular and ...
Betleja, Ewelina +8 more
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Primary Cilia: Putting Sensors Together [PDF]
Current Biology, 2004 Primary cilia extend like antennae from the surface of most eukaryotic cells into the environment, where they function in a variety of sensory roles. Recent studies reveal an intimate interplay between structural proteins of the centrosome and the formation of primary cilia, and provide new insight into the complex function of these fascinating ...
openaire +2 more sources
Adipogenic Differentiation of hMSCs is Mediated by Recruitment of IGF-1r Onto the Primary Cilium Associated With Cilia Elongation [PDF]
, 2015 Funded by Marie Curie Intra European Fellowship (GENOMICDIFF) Wellcome Trust ...
Chapple, JP +4 more
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Renal epithelial cells retain primary cilia during human acute renal allograft rejection injury
BMC Research Notes, 2019 Objectives Primary cilia are sensory organelles which co-ordinate several developmental/repair pathways including hedgehog signalling. Studies of human renal allografts suffering acute tubular necrosis have shown that length of primary cilia borne by ...
Elizabeth Verghese +9 more
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Shortened primary cilium length and dysregulated Sonic hedgehog signaling in Niemann-Pick C1 disease [PDF]
, 2017 The Niemann-Pick type C1 (NPC1) disease is a neurodegenerative lysosomal storage disorder due to mutations in the NPC1 gene, encoding a transmembrane protein related to the Sonic hedgehog receptor, Patched, and involved in intracellular trafficking of ...
Canterini, Sonia +7 more
core +1 more source
Autophagy and primary cilia: dual interplay [PDF]
Current Opinion in Cell Biology, 2016 Primary cilia are microtubule-based organelles for sensing of the extracellular milieu and transducing this information into the cell through a variety of molecular signaling pathways. Functioning of the primary cilium has been recently connected to autophagy, a pathway for degradation of cellular components in lysosomes. Autophagy regulates the length
Olatz, Pampliega, Ana Maria, Cuervo
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Scientific Reports, 2023 Primary cilia are key regulators of embryo development and tissue homeostasis. However, their mechanisms and functions, particularly in the context of human cells, are still unclear.
Lucia Binó, Lukáš Čajánek
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2021 Mechanotransduction is a well-known mechanism by which cells sense their surrounding mechanical environment, convert mechanical stimuli into biochemical signals, and eventually change their morphology and functions.
Tien-Dung Do +3 more
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NDP Kinase Moves into Developing Primary Cilia [PDF]
, 2004 Inmunofluorescence staining of murine NIH3T3 fibroblasts grown at high density shows that conventional nucleoside diphosphate (NDP) kinases A and B localize to a sensory organelle, the primary cilium.
Gallagher, Betty C. +3 more
core +2 more sources