Results 61 to 70 of about 76,105 (304)
Primary Cilium Identifies a Quiescent Cell Population in the Human Intestinal Crypt
Cells, 2023 Primary cilia are sensory antennae located at the cell surface which mediate a variety of extracellular signals involved in development, tissue homeostasis, stem cells and cancer.
Blanche Sénicourt +6 more
doaj +1 more source
Stimulation of electro-olfactogram responses in the main olfactory epithelia by airflow depends on the type 3 adenylyl cyclase [PDF]
, 2012 Cilia of olfactory sensory neurons are the primary sensory organelles for olfaction. The detection of odorants by the main olfactory epithelium (MOE) depends on coupling of odorant receptors to the type 3 adenylyl cyclase (AC3) in olfactory cilia.
Chen, Xuanmao +2 more
core +2 more sources
Primary Cilia and Mammalian Hedgehog Signaling [PDF]
Cold Spring Harbor Perspectives in Biology, 2016 It has been a decade since it was discovered that primary cilia have an essential role in Hedgehog (Hh) signaling in mammals. This discovery came from screens in the mouse that identified a set of genes that are required for both normal Hh signaling and for the formation of primary cilia.
Fiona, Bangs, Kathryn V, Anderson
openaire +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Primary Cilia Are Critical Regulators of White Adipose Tissue Expansion
Frontiers in Physiology, 2021 The primary cilium is a microtubule-based cellular protrusion found on most mammalian cell types in diverse tissues. It functions as a cellular antenna to sense and transduce a broad range of signals, including odorants, light, mechanical stimuli, and ...
Keren I. Hilgendorf
doaj +1 more source
Isolation of Primary Cilia by Shear Force [PDF]
, 2013 The cell’s primary cilium is both a mechanical and chemical sensor involved in many signaling pathways. In order to ascertain protein enrichment in the primary cilium or study sub-ciliary localization of various proteins, it is advantageous to remove the
Mitchell, Kimberly A. P.
core +2 more sources
Primary cilia and forebrain development
Mechanisms of Development, 2013 With a microtubule-based axoneme supporting its plasma membrane-ensheathed projection from the basal body of almost all cell types in the human body, and present in only one copy per cell, the primary cilium can be considered an organelle sui generis.
Willaredt, Marc August +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Characterization of astrocytic primary cilia in the adult mouse cortex and hippocampus
HeliyonThe primary cilium is a single, antenna-like projection found on the surface of eukaryotic cells. Primary cilia contain cell signaling components that are critical for developmental patterning and cell cycle maintenance.
Sylvie C. Lahaie +13 more
doaj +1 more source
The Roles of Primary Cilia in Cardiovascular Diseases
Cells, 2018 Primary cilia are microtubule-based organelles found in most mammalian cell types. Cilia act as sensory organelles that transmit extracellular clues into intracellular signals for molecular and cellular responses.
Rajasekharreddy Pala +3 more
doaj +1 more source