Results 61 to 70 of about 4,340,608 (283)

Regulation of primary cilia formation by ceramide [PDF]

Journal of Lipid Research, 2009
The primary cilium is an important sensory organelle, the regulation of which is not fully understood. We found that in polarized Madin-Darby Canine Kidney cells, the sphingolipid ceramide is specifically distributed to a cis-Golgi compartment at the base of the primary cilium. This compartment immunostained for the centrosome marker gamma-tubulin, the
Guanghu Wang, Kannan Krishnamurthy, Erhard Bieberich   +2 more
openaire   +3 more sources

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

Primary Cilium Identifies a Quiescent Cell Population in the Human Intestinal Crypt

Cells, 2023
Primary cilia are sensory antennae located at the cell surface which mediate a variety of extracellular signals involved in development, tissue homeostasis, stem cells and cancer.
Blanche Sénicourt, Gabriel Cloutier, Nuria Basora, Sepideh Fallah, Andréanne Laniel, Christine Lavoie, Jean-François Beaulieu   +6 more
doaj   +1 more source

A novel mutation causing nephronophthisis in the Lewis polycystic kidney rat localises to a conserved RCC1 domain in Nek8 [PDF]

, 2012
Background Nephronophthisis (NPHP) as a cause of cystic kidney disease is the most common genetic cause of progressive renal failure in children and young adults.
Morahan, G., Mathew I Bellgard, Roberto A Barrero, Morahan, G, McCooke, J.K., Bellgard, MI, Jacqueline K Phillips, Ding, A., John K McCooke, Appels, R, Grant Morahan, Phillips, J.K., Justyna E Ozimek-Kulik, Phillips, JK, Bellgard, M.I., Barrero, RA, McCooke, JK, Appels, R., Barrero, R.A., Ozimek-Kulik, J.E., Rudi Appels, Alice Ding, Ozimek-Kulik, JE, Ding, A   +23 more
core   +1 more source

Engineering Concentration‐Dependent Intravitreal Mobility via Cyclic Arginine‐Enriched Nanocarrier Surface Modification: In Vivo Proof‐of‐Concept in a Porcine Large Animal Model

Advanced Healthcare Materials, EarlyView.
In this study, Hammer et al. highlight cyclic‐arginine surface engineering as a highly biocompatible, controllable, and concentration‐dependent regulator of intravitreal nanoparticle mobility in vivo in a translational large animal model. The cyclic arginine surface‐modification supports the development of next‐generation biomaterials for long‐acting ...
Maximilian Hammer, Bryan Calder Ackermann, Anna Stoß, Niklas Junker, Ludwig Geisweid, Sabrina Wohlfart, Jonathan Herth, Simon William Pohl, Manuel Ben Böhmann, André Schulz, Victor Aristide Augustin, Gerd Uwe Auffarth, Philipp Uhl   +12 more
wiley   +1 more source

Combined exome and whole-genome sequencing identifies mutations in ARMC4 as a cause of primary ciliary dyskinesia with defects in the outer dynein arm. [PDF]

, 2013
Primary ciliary dyskinesia (PCD) is a rare, genetically heterogeneous ciliopathy disorder affecting cilia and sperm motility. A range of ultrastructural defects of the axoneme underlie the disease, which is characterised by chronic respiratory symptoms ...
Danke-Roelse, JE, Hart, S.L., Munye, Mustafa M., Scambler, PJ, Rosser, E.M., Hart, Stephen L, Beales, Philip L, Bacchelli, C, Moore, Anthony T., Chung, Eddie MK, Sloper, John J, Danke-Roelse, Jeannette E, Moore, A.T., Pals, Gerard, Beales, Philip L., Sloper, John J., Moore, Anthony T, Hogg, C, Hogg, C., Bacchelli, Chiara, Mitchison, Hannah M, Shoemark, A., Moore, AT, James, C.T., Scambler, Peter J, Chung, E.M.K., Rosser, Elisabeth M., Bacchelli, C., Shoemark, Amelia; id_orcid, Patel, M., Hogg, Claire, Onoufriadis, Alexandros, Schmidts, Miriam, Emes, R.D., Munye, Mustafa M, Hull, S., Sloper, JJ, Hull, Sarah, Beales, PL, Beales, P.L., Hart, Stephen L., Munye, MM, Schmidts, M, James, Chela T, Scambler, P.J., James, Chela T., Mitchison, H.M., nke-Roelse, J.E., Hull, S, Onoufriadis, A., Rosser, Elisabeth M, Emes, Richard D., Patel, Mitali, Pals, G., Mitchison, Hannah M., Patel, M, Pals, G, Emes, RD, Munye, M.M., James, CT, Schmidts, M., Danke-Roelse, Jeannette E., Chung, Eddie M.K., Shoemark, Amelia, Mitchison, HM, Emes, Richard D, Chung, EM, Shoemark, A, Onoufriadis, A, Sloper, J.J., Hart, SL, Rosser, EM, Scambler, Peter J.   +72 more
core   +1 more source

Methods for studying primary cilia in heart tissue after ischemia-reperfusion injury

, 2023
Funding Information: This work was supported by the Agencia Nacional de Investigación y Desarrollo de Chile (ANID, Chile): FONDECYT [1200499 to E.M., 1191078 to R.T., 11181000 to J.A.R. and 1211329 to A.C., 1200490 to S.L]; PIA-ANID [ACT172066 to R.T., E.
Lavandero, Sergio, Criollo, Alfredo, Universidad San Sebastián, Riquelme, Jaime A., Peña-Oyarzún, Daniel, Hill, Joseph A., Bravo-San Pedro, José Manuel, Díaz-Castro, Francisco, Galluzzi, Lorenzo, Reyes, Montserrat, Budini, Mauricio, García-Navarrete, Camila, Hernández-Cáceres, María Paz, Morselli, Eugenia, Kretschmar, Catalina, Troncoso, Rodrigo   +15 more
core   +1 more source

Azobenzene's Cross‐Scale Optics and Photonics: Molecular Photoswitching, Mesoscopic Material Motions, and Adaptive Devices

Advanced Materials, EarlyView.
Azobenzene photoswitches translate molecular‐scale E/Z photoisomerization into macroscopic material responses and device‐level photonic functions. This Review highlights how azobenzene research has evolved from molecular photochemistry to photoalignment, mass migration, photomechanics, and heat release, ultimately enabling holography, reconfigurable ...
Heeju Son, Soyul Kwak, Heerin Noh, Minsang Kim, Doyeon Noh, Subhayan Chakraborty, Jaewon Lee, YongDeok Cho, Kyeongsoo Kim, Taewoong Eom, Moonyoung Kim, Jangwon Kim, Hoyoung Lee, Soyoung Lee, Jaehun Kim, Grace G. D. Han, Shin‐Tson Wu, Stefano Oscurato, Arri Priimagi, Marina Saphiannikova, Seungwoo Lee   +20 more
wiley   +1 more source

Functional modulation of IFT kinesins extends the sensory repertoire of ciliated neurons in Caenorhabditis elegans [PDF]

, 2006
The diversity of sensory cilia on Caenorhabditis elegans neurons allows the animal to detect a variety of sensory stimuli. Sensory cilia are assembled by intraflagellar transport (IFT) kinesins, which transport ciliary precursors, bound to IFT particles,
James E. Evans, Kent L. McDonald, Amy L. Gunnarson, Gunnarson, Amy L., Guangshuo Ou, Snow, JJ, McDonald, KL, Stahlberg, Henning, Ou, Guangshuo, Ou, GS, Evans, JE, Stahlberg, H, Evans, James E., Jonathan M. Scholey, Scholey, JM, Gunnarson, AL, McDonald, Kent L., Joshua J. Snow, Henning Stahlberg, Snow, Joshua J., Scholey, Jonathan M.   +20 more
core   +1 more source