Results 71 to 80 of about 4,340,608 (283)

Islet primary cilia motility controls insulin secretion [PDF]

, 2022
Primary cilia are specialized cell-surface organelles that mediate sensory perception and, in contrast to motile cilia and flagella, are thought to lack motility function.
Hughes, Jing W., Bayly, Philip V., Bayly, Philip V, Li, Zipeng A., Hughes, Jing W, Zhu, Lifei, Woodhams, Louis G., Muegge, Brian D, Muegge, Brian D., Lee, Eun Young, Roseman, Henry F., Utterback, Toby, Roseman, Henry F, Cho, Jung Hoon, Woodhams, Louis G, Li, Zipeng A   +15 more
core   +1 more source

Engineering Pluripotent Stem Cells‐Derived Inner Ear Organoids With Enhanced Maturation and Reproducibility by Micro‐Topographical Cues

Advanced Materials, EarlyView.
Micro‐topographical cues applied through temporally controlled microscale confinement improve the reproducibility, spatial organization, and neurosensory‐associated features of pluripotent stem cell‐derived inner ear organoids. Integration with a vascularized organoid platform further enables controlled investigation of vascular‐epithelial interactions
Harshita Sharma, Jungeun Lim, Woochan Kim, Yeon Ju Kim, Dream Kim, Shinyull Lee, Chaeyeon Park, Stephen Rhee, Shruthy Kuttapan, Jungho Ha, Sang Wook Park, Kyunghoon Kim, Noo Li Jeon, Sunho Park, Yun‐Hoon Choung, Jangho Kim   +15 more
wiley   +1 more source

CU Cilia – an application for image analysis by machine learning – reveals significance of cysteine cathepsin K activity for primary cilia of human thyroid epithelial cells

Frontiers in Endocrinology
IntroductionCysteine cathepsins K and L are crucial for proper thyroid function in mice. Inhibition of cysteine peptidases in rodent thyroid epithelial cells in vitro results in loss of primary cilia, highlighting the significance of proteolysis for ...
Maren Rehders, Kseniia Alekseitseva, João Gissoni, Alara G. Doğru, Petr Popov, Petr Popov, Petr Popov, Andrei Boiarov, Klaudia Brix   +8 more
doaj   +1 more source

Tethered fleximags as artificial cilia [PDF]

, 2011
Flexible superparamagnetic filaments ('fleximags') are very slender elastic filaments, which can be driven by distributed magnetic torques to mimic closely the behaviour of biological flagella.
OLIVIA DU ROURE, Fermigier, Marc, Du Roure, Olivia, MARC FERMIGIER, Roper, Marcus, Babataheri, Avin, AVIN BABATAHERI, MARCUS ROPER   +7 more
core   +1 more source

Recent Advances of Slip Sensors for Smart Robotics

Advanced Materials Technologies, EarlyView.
This review summarizes recent progress in robotic slip sensors across mechanical, electrical, thermal, optical, magnetic, and acoustic mechanisms, offering a comprehensive reference for the selection of slip sensors in robotic applications. In addition, current challenges and emerging trends are identified to advance the development of robust, adaptive,
Xingyu Zhang, Liao Wu, Shuai He, Zhao Sha, Yuwan Huang, Shuying Wu, Dewei Chu, Chun H. Wang, Shuhua Peng   +8 more
wiley   +1 more source

Enhanced release of ciliary extracellular vesicles suppresses cell migration and promotes cell aggregation

Cell Structure and Function
A primary cilium is a hair-like organelle that protrudes from the cell surface in many cell types. Growing evidence indicates that extracellular vesicles are released from primary cilia, and research is increasingly focused on defining the functions of ...
Tetsuhiro Hara, Ryota Nakazato, Kenji Shirakawa, Faryal Ijaz, Kenichiro Uemura, Shinya Takahashi, Koji Ikegami   +6 more
doaj   +1 more source

Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling [PDF]

European Cells & Materials, 2017
Tissue engineering-based therapies targeting cartilage diseases, such as osteoarthritis, require in vitro expansion of articular chondrocytes. A major obstacle for these therapies is the dedifferentiation and loss of phenotype accompanying chondrocyte ...
CL Thompson, JCT Plant, AKT Wann, CL Bishop, P Novak, HM Mitchison, PL Beales, JP Chapple, MM Knight   +8 more
doaj   +1 more source

Primary Cilia in the Skin: Functions in Immunity and Therapeutic Potential

Frontiers in Cell and Developmental Biology, 2021
The skin is the biggest organ and provides a physical and immunological barrier against pathogen infection. The distribution of primary cilia in the skin of mice has been reported, but which cells in human skin have them has not, and we still know very ...
Manami Toriyama, Manami Toriyama, Manami Toriyama, Ken J. Ishii, Ken J. Ishii, Ken J. Ishii   +5 more
doaj   +1 more source

Primary ciliary dyskinesia: current state of the art

, 2007
Primary ciliary dyskinesia (PCD) is usually inherited as an autosomal recessive, and in classical form presents with upper and lower respiratory tract infection, and mirror image arrangement in around 50% cases.
Hall, Pippa, Collins, Nicola F., Hariri, Mohamed, Harcourt, Jonny, Chodhari, Rahul, Lucas, Jane, Phillips, Gill, Bush, Andrew, Copeland, Fiona, Hogg, Claire, O'Callaghan, Chriatopher   +10 more
core   +1 more source

Adipogenic Differentiation of hMSCs is Mediated by Recruitment of IGF-1r Onto the Primary Cilium Associated With Cilia Elongation [PDF]

, 2015
Funded by Marie Curie Intra European Fellowship (GENOMICDIFF) Wellcome Trust ...
Thorpe, SD, Connelly, JT, Dalbay, MT, Chapple, JP, Knight, MM   +4 more
core   +1 more source