Results 71 to 80 of about 42,278 (249)

Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling [PDF]

European Cells & Materials, 2017
Tissue engineering-based therapies targeting cartilage diseases, such as osteoarthritis, require in vitro expansion of articular chondrocytes. A major obstacle for these therapies is the dedifferentiation and loss of phenotype accompanying chondrocyte ...
CL Thompson, JCT Plant, AKT Wann, CL Bishop, P Novak, HM Mitchison, PL Beales, JP Chapple, MM Knight   +8 more
doaj   +1 more source

Hard‐Magnetic Soft Millirobots in Underactuated Systems

Advanced Robotics Research, EarlyView.
This review provides a comprehensive overview of hard‐magnetic soft millirobots in underactuated systems. It examines key advances in structural design, physics‐informed modeling, and control strategies, while highlighting the interplay among these domains.
Qiong Wang, Zixuan Zhang, Bingyan Li, Junkai Wang, Hongcheng Gu   +4 more
wiley   +1 more source

Toward Wireless Implantable Robotic Systems Driven by Magnetic Field for Personalized Therapy

Advanced Robotics Research, EarlyView.
Robotic materials are playing an increasingly vital role in enabling sensing and actuation at small scales. This perspective highlights recent advances in magnetic materials and magnetically actuated devices for wireless sensing, actuation, and energy harvesting toward implantable robotic systems for closed‐loop therapy.
Yusheng Wang, Ruijian Ge, Xiaoguang Dong
wiley   +1 more source

Identification and characterization of a novel allele of Caenorhabditis elegans bbs-7. [PDF]

PLoS ONE, 2014
Primary cilia play a role in the sensation of and response to the surrounding environment. Caenorhabditis elegans (C. elegans) have primary cilia only on the distal tips of some dendrites.
Kara Braunreiter, Shelby Hamlin, Jamie Lyman-Gingerich   +2 more
doaj   +1 more source

Primary ciliary dyskinesia (Siewert's/Kartagener's syndrome): respiratory symptoms and psycho-social impact

, 2003
Although the pathophysiological defect in primary ciliary dyskinesia (PCD; Siewert's/Kartagener's syndrome) is now well characterised, there are few studies of the impact of the condition upon health function, particularly in later life.
I Christopher McManus, McManus, IC, Martin, N, Chung Eddie MK, Mitchison Hannah M, Mitchison, HM, Georgina F Stubbings, Chung, EM, Naomi Martin, Stubbings Georgina F, Martin Naomi, Hannah M Mitchison, Stubbings, GF, McManus I, Eddie MK Chung   +14 more
core   +1 more source

Magnetic Micro‐ and Nanorobots for Precision Thrombolysis: Design Strategies and Translational Challenges

Advanced Robotics Research, EarlyView.
Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin, Yimo Yan, Nikola Cesarovic, Simone Schuerle   +3 more
wiley   +1 more source

Modulating primary cilia and cilia-dependent Shh signaling increases retinal ganglion cell survival by repressing astrocyte reactivity after optic nerve injury

Neurobiology of Disease
The primary cilia and cilia-dependent signaling are key regulators of neurodegenerative diseases. However, their roles in glaucoma and optic nerve injury remain largely unexplored.
Quanyu He, Xuehan Liu, Qi Zhang, Yuxuan Qiu, Jiahui Tang, Bing Zhang, Siting Wu, Canying Liu, Liyan Liu, Yehong Zhuo, Yiqing Li   +10 more
doaj   +1 more source

Strategic Design of Soft Actuators in Translational Medical Robotics for Human‐Centered Healthcare

Advanced Robotics Research, EarlyView.
Soft robotics enables biocompatible, compliant medical devices, but clinical translation requires design‐driven engineering beyond materials. This perspective reviews implantable, surgical, and wearable systems by actuation mechanism, highlighting how optimized architectures and integration improve mechanical interfacing, adaptability, and durability ...
Ho Jun Jin, Jimin Kim, Inho Kim, Bong Hoon Kim   +3 more
wiley   +1 more source

Cis‐ and Trans‐Regulatory Factors Independently Shape Phenotypic Heterogeneity of Retinitis Pigmentosa

Advanced Science, EarlyView.
A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui, Kotone Nakagawa, Takumi Tateno, Ayaka Dan, Dexin Meng, Yoshihiro Omori, Soma Tomihara, Suzuri Okamoto, Shigeru Sato, Motokazu Tsujikawa   +9 more
wiley   +1 more source

Primary Cilia as a Signaling Platform for Control of Energy Metabolism [PDF]

Diabetes & Metabolism Journal, 2018
Obesity has become a common healthcare problem worldwide. Cilia are tiny hair-like organelles on the cell surface that are generated and anchored by the basal body.
Do Kyeong Song, Jong Han Choi, Min-Seon Kim   +2 more
doaj   +1 more source