Results 91 to 100 of about 42,278 (249)

Primary cilia defects causing mitral valve prolapse

, 2019
Mitral valve prolapse (MVP) affects 1 in 40 people and is the most common indication for mitral valve surgery. MVP can cause arrhythmias, heart failure, and sudden cardiac death, and to date, the causes of this disease are poorly understood.
Mukherjee, Rupak, Rog-Zielinska, Eva A., Norris, Russell A, Body, Simon, Ellinor, Patrick T, Le Tourneau, Thierry, Toomer, Katelynn A, Wessels, Andy, Glover, Janiece, Markwald, Roger R, Drayton, Ka'la D, Hagege, Albert, Stairley, Rebecca, Kohl, Peter, Leyne, Maire, Awgulewitsch, Alexander, Rog-Zielinska, Eva A, Hazard, E. Starr, Moore, Reece, Drayton, Ka’la D., Delling, Francesca N, Lipschutz, Joshua H, Moore, Kelsey S, Hardiman, Gary; id_orcid, Milan, David J, Del Monte, Federica, Levine, Robert A, Dina, Christian, Fulmer, Diana, Ellinor, Patrick T., Drohan, Alex, Bouatia-Naji, Nabila, Levine, Robert A., Slaugenhaupt, Susan A., Schott, Jean-Jacques, Talkowski, Michael E, Moore, Kelsey S., Ramos-Ortiz, Sandra, Brand, Harrison, Toomer, Katelynn A., Milan, David J., Hazard, E Starr, Lipschutz, Joshua H., da Silveira, Willian A., Hardiman, Gary, Peterson, Neal, Le Scouarnec, Solena, Catching, Breiona J, Jeunemaitre, Xavier, da Silveira, Willian A, Delling, Francesca N., Collins, Ryan L., Slaugenhaupt, Susan A, Talkowski, Michael E., Durst, Ronen, Yu, Mengyao, Catching, Breiona J., Wang, Baolin, Guo, Lilong, Collins, Ryan L, Markwald, Roger R., Norris, Russell A.   +61 more
core   +2 more sources

Biofilm Exoproteins From Staphylococcus Species Impede Re‐Epithelialization of Nasal Epithelial Cells During Wound Healing and Cease Ciliary Beat Frequency

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Introduction Chronic rhinosinusitis (CRS) is an inflammatory disease with many different contributing factors, including bacterial infection. CRS patients are typically managed with medical therapies; however, these treatments frequently fail, leaving surgery as the only viable option.
Sintayehu Ambachew, Mahnaz Ramezanpour, Clare M. Cooksley, Emma F. Barry, Lindsay Durr, Kevin Aaron Fenix, P. J. Wormald, Alkis J. Psaltis, Sarah Vreugde   +8 more
wiley   +1 more source

Assembly of primary cilia.

, 2008
Primary cilia are microtubule-based, hair-like sensory organelles present on the surface of most growth-arrested cells in our body. Recent research has demonstrated a crucial role for primary cilia in regulating vertebrate developmental pathways and ...
Christensen, Søren T, Schrøder, Jacob M, Schrøder, Jacob Morville, Pedersen, Lotte Bang, Veland, Iben Rønn, Veland, Iben R, Pedersen, Lotte B, Christensen, Søren Tvorup   +7 more
core   +1 more source

Female‐Specific Risk of TAS2R Variants in Chronic Rhinosinusitis: A Hospital‐Based Cohort Study From the Taiwan Precision Medicine Initiative

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Bitter taste receptors (T2Rs) function in the innate immune defense of the sinonasal mucosa; however, the genetic association between the TAS2R gene family and chronic rhinosinusitis (CRS) remains understudied in Asian populations.
Rong‐San Jiang, Man‐Wei Hua, I‐Chieh Chen, Yi‐Ming Chen, Shun‐Hung Lin, Kuan‐Yu Lai, Yi‐Chen Chen   +6 more
wiley   +1 more source

The role of primary cilia and sonic hedgehog signalling in adrenal development function.

, 2012
PhDPrimary cilia are sensory organelles found on most vertebrate cells during interphase. They play key roles in development, cell signalling and cancer, and are involved in signal transduction pathways such as Hh and Wnt signalling.
Cogger, Kathryn
core  

Tubulin glycylation controls primary cilia length

, 2017
As essential components of the eukaryotic cytoskeleton, microtubules fulfill a variety of functions that can be temporally and spatially controlled by tubulin posttranslational modifications.
Sudarshan Gadadhar, Filippo Rusconi, Satish Bodakuntla, Anne Schnitzler, Carsten Janke, Hala Dadi, Ivan Bièche   +6 more
core   +1 more source

Partial hearing recovery after cochlear nerve surface transplantation of hair follicle‐derived neural crest stem cells in neural hearing loss rat

Animal Models and Experimental Medicine, EarlyView.
This study comprises three experimental parts. Part 1. Time‐course of ouabain‐induced hearing loss. Rats received ouabain (10 mM) via round window application. ABR/DPOAE tests and histological analyses were performed at 2, 7, and 30 days post‐treatment to characterize SGN and glial cell degeneration. Part 2.
Huidong Chen, Yunlong Zhang, Huanzhi Wan, Bingqian Yang, Tianyi Liu, Jie Wang, Hua Liao, Yuanyuan Zhang, Zhijian Zhang, Qingquan Hua   +9 more
wiley   +1 more source

Injectable Bone Cements: A Generational Framework for Bioactivity, Porosity, and Mechanobiological Design at the Nanoscale

Advanced NanoBiomed Research, EarlyView.
Key demographic, biological, and material considerations that drive the need for advanced injectable bone cement technologies. Injectable bone cements (IBCs) are widely used in orthopaedic and craniofacial applications due to their minimally invasive delivery and ability to provide early mechanical stabilisation.
Frank Fei, Yogambha Ramaswamy, Young Jung No   +2 more
wiley   +1 more source

Cilia-mediated signalling in the embryonic nodes: A computational fluid-structure-protein interaction (FSPI) model

, 2009
This paper was presented at the 2nd Micro and Nano Flows Conference (MNF2009), which was held at Brunel University, West London, UK. The conference was organised by Brunel University and supported by the Institution of Mechanical Engineers, IPEM, the ...
2nd Micro and Nano Flows Conference (MNF2009), Norris, D, Chen, D, Ventikos, Y   +3 more
core  

Tissue Damage in Rheumatoid Arthritis Is Genetically Linked to Low Peptidylglycine Alpha‐Amidating Monooxygenase Activity in Synovial Fibroblasts

Arthritis &Rheumatology, EarlyView.
Objective Both susceptibility to, and severity of, rheumatoid arthritis (RA) is associated with the rs26232 C allele. Our primary aim was to identify the biologic mechanism underlying this association. Methods Expression of surrounding genes was compared among rs26232 genotypes.
Kevin J. Sheridan, Emma R. Dorris, Maria Inês Pimenta, Jemma Falkov, Matthew Fisher, Sam Pledger, Hector Devey, Munitta Muthana, Denis C. Shields, Richard E. Mains, Betty A. Eipper, Christopher D. Buckley, Anthony G. Wilson   +12 more
wiley   +1 more source