Results 81 to 90 of about 76,105 (304)

Using Primary Neurosphere Cultures to Study Primary Cilia

Journal of Visualized Experiments, 2017
The primary cilium is fundamentally important for the proliferation of neural stem/progenitor cells and for neuronal differentiation during embryonic, postnatal, and adult life. In addition, most differentiated neurons possess primary cilia that house signaling receptors, such as G-protein-coupled receptors, and signaling molecules, such as adenylyl ...
Issei S, Shimada, Hemant, Badgandi, Bandarigoda N, Somatilaka, Saikat, Mukhopadhyay   +3 more
openaire   +3 more sources

Flexible Dielectric Acoustic Resonator Patch for Tissue Regeneration

Advanced Materials, EarlyView.
A flexible dielectric acoustic resonator patch enables MHz‐range ultrasound generation through resonance amplification without using piezoelectric materials. Conformal integration on a curved substrate allows efficient acoustic delivery to tissue‐mimicking environments.
Donyoung Kang, Byeongseok Ryu, Sujeong Ahn, Junhyub Kim, Myeonghun Jang, Jeong Ho Cho, Won‐Gun Koh, Hyungsuk Lee   +7 more
wiley   +1 more source

Roles of Primary Cilia in the Developing Brain

Frontiers in Cellular Neuroscience, 2019
Essential to development, primary cilia are microtubule-based cellular organelles that protrude from the surface of cells. Acting as cellular antenna, primary cilia play central roles in transducing or regulating several signaling pathways, including ...
Sang Min Park, Hee Jin Jang, Jeong Ho Lee, Jeong Ho Lee   +3 more
doaj   +1 more source

NRF2 and Primary Cilia: An Emerging Partnership

Antioxidants, 2020
When not dividing, many cell types target their centrosome to the plasma membrane, where it nucleates assembly of a primary cilium, an antenna-like signaling structure consisting of nine concentric microtubule pairs surrounded by membrane.
Ana Martin-Hurtado, Isabel Lastres-Becker, Antonio Cuadrado, Francesc R. Garcia-Gonzalo   +3 more
doaj   +1 more source

Recent Advances of Slip Sensors for Smart Robotics

Advanced Materials Technologies, EarlyView.
This review summarizes recent progress in robotic slip sensors across mechanical, electrical, thermal, optical, magnetic, and acoustic mechanisms, offering a comprehensive reference for the selection of slip sensors in robotic applications. In addition, current challenges and emerging trends are identified to advance the development of robust, adaptive,
Xingyu Zhang, Liao Wu, Shuai He, Zhao Sha, Yuwan Huang, Shuying Wu, Dewei Chu, Chun H. Wang, Shuhua Peng   +8 more
wiley   +1 more source

CU Cilia – an application for image analysis by machine learning – reveals significance of cysteine cathepsin K activity for primary cilia of human thyroid epithelial cells

Frontiers in Endocrinology
IntroductionCysteine cathepsins K and L are crucial for proper thyroid function in mice. Inhibition of cysteine peptidases in rodent thyroid epithelial cells in vitro results in loss of primary cilia, highlighting the significance of proteolysis for ...
Maren Rehders, Kseniia Alekseitseva, João Gissoni, Alara G. Doğru, Petr Popov, Petr Popov, Petr Popov, Andrei Boiarov, Klaudia Brix   +8 more
doaj   +1 more source

Magnetic Droplet Manipulation on Open Surfaces

Advanced Materials Technologies, EarlyView.
Recent advances in the manipulation of magnetic droplets demonstrate various manipulations on open surfaces, including transport, splitting, merging, and force‐controlled motion, enabled by magnetic particles and external fields. ABSTRACT Manipulation of liquids on a smaller scale enables applications in various fields, particularly diagnostics and ...
Robab Jahangir, Vahid Nasirimarekani
wiley   +1 more source

Enhanced release of ciliary extracellular vesicles suppresses cell migration and promotes cell aggregation

Cell Structure and Function
A primary cilium is a hair-like organelle that protrudes from the cell surface in many cell types. Growing evidence indicates that extracellular vesicles are released from primary cilia, and research is increasingly focused on defining the functions of ...
Tetsuhiro Hara, Ryota Nakazato, Kenji Shirakawa, Faryal Ijaz, Kenichiro Uemura, Shinya Takahashi, Koji Ikegami   +6 more
doaj   +1 more source

RPGR protein complex regulates proteasome activity and mediates store-operated calcium entry [PDF]

, 2018
Ciliopathies are a group of genetically heterogeneous disorders, characterized by defects in cilia genesis or maintenance. Mutations in the RPGR gene and its interacting partners, RPGRIP1 and RPGRIP1L, cause ciliopathies, but the function of their ...
Aguirre, Anselme, Aravind, Beales, Bergen, Berger, Berson, Billaud, Burnside, Burridge, Cahalan, Carroll, Chapman, Cossart, Ferreira, Ferreira, Fuchs, Habas, He, Hildebrandt, Hogan, Imanishi, Jacobson, Johnson, Kaibuchi, Katsanis, Kaykas, Kelley, Khaliq, Khanna, Khanna, Kroes, Lewis, Li, Li, Li, MacDonald, MacDonald, Meyer, Mitchell, Nelson, Nishina, Nusse, Prevarskaya, Putney, Ridley, Roepman, Rosado, Rüther, Rüther, Sage, Schermer, Schneider-Maunoury, Shu, Stainier, Tolwinski, Torban, Vaudin, Vervoort, Vesque, Wallingford, Wittinghofer, Wolfrum, Wright, Wright, Wright, Wright, Wright, Zrenner   +68 more
core   +3 more sources

HIF Stabilization Weakens Primary Cilia

PLOS ONE, 2016
Although solitary or sensory cilia are present in most cells of the body and their existence has been known since the sixties, very little is known about their functions. One suspected function is fluid flow sensing- physical bending of cilia produces an influx of Ca++, which can then result in a variety of activated signaling pathways. Defective cilia
openaire   +4 more sources