Results 81 to 90 of about 37,275 (255)

Structure, function, and research progress of primary cilia in reproductive physiology and reproductive diseases

Frontiers in Cell and Developmental Biology
Primary cilia, serving as the central hub for cellular signal transduction, possess the remarkable ability to translate diverse extracellular signals, both chemical and mechanical, into intracellular responses.
Xiaochuan Long, Xiaochuan Long, Li Chen, Li Chen, Xinyao Xiao, Xinyao Xiao, Xiayu Min, Xiayu Min, Yao Wu, Yao Wu, Zengming Yang, Zengming Yang, Xin Wen, Xin Wen   +13 more
doaj   +1 more source

Prdx1 promotes the loss of primary cilia in esophageal squamous cell carcinoma

BMC Cancer, 2020
Background Loss of primary cilia is frequently observed in tumor cells, suggesting that the absence of this organelle may promote tumorigenesis through aberrant signal transduction, the inability to exit the cell cycle, and promotion of tumor cell ...
Qiongzhen Chen, Jinmeng Li, Xiaoning Yang, Junfeng Ma, Fanghua Gong, Yu Liu   +5 more
doaj   +1 more source

The KIF6‐RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly

Advanced Science, EarlyView.
Two homozygous deleterious KIF6 variants are identified in unrelated men with impaired sperm motility. Mouse models and multi‐omics analyses reveal that KIF6 cooperates with the RNA‐binding proteins FMRP and FXR1 to deliver mRNAs essential for sperm flagellar assembly, linking disrupted mRNA transport to reduced abundance of key structural and ...
Chunbo Xie, Sibing Yi, Xinle Lin, Shen Zhang, Weili Wang, Shimin Yuan, Lanlan Meng, Yong Li, Chen Tan, Chunjia Wei, Yanyan Yu, Yaoqiong Liang, Huan Zhang, Liang Hu, Guangxiu Lu, Wenbin He, Qianjun Zhang, Juan Du, Ge Lin, Chaofeng Tu, Yue‐Qiu Tan   +20 more
wiley   +1 more source

Primary cilia and their role in cancer.

Oncology letters, 2019
Primary cilia are microtubule-based organelles that are expressed on almost all mammalian cells. It has become apparent that these structures are important signaling hubs that serve crucial roles in Wnt, hedgehog, extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) and Notch signaling pathways.
Higgins, Michael, Obaidi, Ismael, McMorrow, Tara   +2 more
openaire   +2 more sources

Single‐Cell and Spatial Transcriptomics Unveil Key Regulators Governing Cell Differentiation for Schistosoma japonicum Sexual Development

Advanced Science, EarlyView.
Using single‐cell and spatial transcriptomics, we identified key regulators that govern cell differentiation involved in parasite development and egg laying in Schistosoma japonicum. This comprehensive study establishes a foundational resource for understanding schistosome biology, deciphers the regulatory programs underlying cell differentiation and ...
Zhigang Lu, Xiaoxu Wang, Shun Li, Xuxin Li, Pengfei Du, Yameng Zheng, Lu Liu, Yanyan Zhang, Omri Wurtzel, Guofeng Cheng   +9 more
wiley   +1 more source

Application of bioactive materials primary cilia as a novel delivery vehicle

Bioactive Materials
Primary cilia are hair-like structured cell organelles functioning as cellular antennae with chemosensory and mechanosensory roles. Dysfunction of cilia results in ciliopathies, including renovascular diseases (polycystic kidneys, hypertension, aneurysm),
Ayan K. Barui, Farideh Amirrad, Vansh Goel, Sharareh Ohadi, Rajasekharreddy Pala, Ashraf M. Mohieldin, Andromeda M. Nauli, Surya M. Nauli   +7 more
doaj   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

A Plant Photoregulator‐Inspired S‐Type Heterojunction System for Diabetic Keratopathy via Tri‐Modal Light‐Driven Immunometabolic Reprogramming, Tissue Repair, and Antibacterial Activity

Advanced Science, EarlyView.
To address the multifaceted imbalance in diabetic keratopathy, a light‐responsive biomimetic platform (WCNx‐Rh2) is developed and integrates glucose degradation, immune modulation, and antibacterial defense through a designed heterojunction and screened immunomodulator. WCNx‐Rh2 reduces AGEs/ROS and inflammatory signaling, reprogramming dendritic cells
Mengzhen Zhao, Zhibin Zhou, Yuxuan Wei, Xiangfan Huang, Zhiyong Zhou, Jiaheng Chen, Haoxin Cheng, Xiaotian Hu, Xiaolei Wang   +8 more
wiley   +1 more source

TRAF6 Lactylation in Glycolytic Macrophages Drives NF‐κB Signaling and M1 Polarization During Orthodontic Tooth Movement

Advanced Science, EarlyView.
Schematic diagram showing compressive stress triggers glycolytic reprogramming and lactate accumulation in macrophages. Lactate mediates TRAF6 lactylation at K171/K180 dual sites, which enhances its K63‐linked ubiquitination to activate the NF‑κB pathway and promote M1 polarization. This cascade drives orthodontic tooth movement (OTM) and alveolar bone
Xinyi He, Guodong Zhao, Yun Hu, Wenya Bai, Hao Tan, Shuai Yuan, Sihan Yang, Ye Zhu, Xiaohui Xu, Leilei Zheng   +9 more
wiley   +1 more source

Dynamic regulation of hypothalamic NPY2R-positive primary cilia by nutritional states

Frontiers in Cell and Developmental Biology
Primary cilia are specialized signaling organelles that concentrate selected G protein-coupled receptors and are important in neuronal and metabolic regulation.
Akie Hamamoto, Nobuya Nishimura, Yumiko Saito, Yuki Kobayashi   +3 more
doaj   +1 more source