Results 11 to 20 of about 4,340,608 (283)
Visualizing renal primary cilia [PDF]
Nephrology, 2013 Renal primary cilia are microscopic sensory organelles found on the apical surface of epithelial cells of the nephron and collecting duct. They are based upon a microtubular cytoskeleton, bounded by a specialized membrane, and contain an array of ...
Elizabeth Verghese (18032992) +7 more
core +4 more sources
GPR88 localization to primary cilia in neurons is cell-type specific [PDF]
Life Science AllianceThis is the first demonstration of cell-type specific GPCR localization to primary cilia in vivo in intact brain tissue. GPR88 is an orphan G protein-coupled receptor that regulates dopamine neurotransmission and is a target for neuropsychiatric ...
Yenni H Li Guan +3 more
doaj +2 more sources
Roles of Primary Cilia in the Developing Brain
Frontiers in Cellular Neuroscience, 2019 Essential to development, primary cilia are microtubule-based cellular organelles that protrude from the surface of cells. Acting as cellular antenna, primary cilia play central roles in transducing or regulating several signaling pathways, including ...
Sang Min Park +3 more
doaj +3 more sources
Redox Biology, 2019 The primary cilium, which protrudes from the cell surface, is associated with the pathogenesis of various diseases, including acute kidney injury (AKI). Primary cilium length dynamically changes during the progression of diseases.
Min Jung Kong +5 more
doaj +3 more sources
Primary cilia in cancer: structures, functions, mechanisms, and therapeutic implications [PDF]
Cancer Biology & MedicinePrimary cilia, microtubule-based organelles protruding from the surfaces of most eukaryotic cells, have critical roles in maintaining cellular homeostasis, by sensing, transducing, and transmitting diverse extracellular and intracellular signals through ...
Miaomiao Zheng, Jun Zhou, Yijie Wang
doaj +2 more sources
Primary Cilia and Atherosclerosis [PDF]
Frontiers in Physiology, 2021 In artery tree, endothelial function correlates with the distribution of shear stress, a dragging force generated by flowing blood. In laminar shear stress areas, endothelial cells (ECs) are available to prevent atherosclerosis, however, ECs in disturbed shear stress sites are featured with proinflammation and atherogenesis.
Zhi-Mei Wang +3 more
openaire +3 more sources
Cilia-mediated signalling in the embryonic nodes: A computational fluid-structure-protein interaction (FSPI) model [PDF]
, 2009 This paper was presented at the 2nd Micro and Nano Flows Conference (MNF2009), which was held at Brunel University, West London, UK. The conference was organised by Brunel University and supported by the Institution of Mechanical Engineers, IPEM, the ...
2nd Micro and Nano Flows Conference (MNF2009) +3 more
core +6 more sources
Calprotectin: An Ignored Biomarker of Neutrophilia in Pediatric Respiratory Diseases
Children, 2021 Calprotectin (CP) is a non-covalent heterodimer formed by the subunits S100A8 (A8) and S100A9 (A9). When neutrophils become activated, undergo disruption, or die, this abundant cytosolic neutrophil protein is released.
Grigorios Chatziparasidis, Ahmad Kantar
doaj +1 more source
Effects of Sesquiterpene Lactones on Primary Cilia Formation (Ciliogenesis)
Toxins, 2023 Sesquiterpene lactones (SLs), plant-derived metabolites with broad spectra of biological effects, including anti-tumor and anti-inflammatory, hold promise for drug development.
Marina Murillo-Pineda +9 more
doaj +1 more source
Current Osteoporosis Reports, 2023 Abstract Purpose of Review The purpose of this review is to provide a background on osteocytes and the primary cilium, discussing the role it plays in osteocyte mechanosensing. Recent Findings Osteocytes are thought to be the primary mechanosensing cells in bone tissue ...
Verbruggen, S.W. +2 more
openaire +4 more sources