Results 11 to 20 of about 4,554,367 (185)

NRF2 and Primary Cilia: An Emerging Partnership [PDF]

Antioxidants, 2020
When not dividing, many cell types target their centrosome to the plasma membrane, where it nucleates assembly of a primary cilium, an antenna-like signaling structure consisting of nine concentric microtubule pairs surrounded by membrane.
Ana Martin-Hurtado, Isabel Lastres-Becker, Antonio Cuadrado, Francesc R. Garcia-Gonzalo   +3 more
doaj   +8 more sources

Emerging Roles of Primary Cilia in Glioma [PDF]

Frontiers in Cellular Neuroscience, 2019
Primary cilia are microtubule-based organelles that are typically present on cells during the G0 or G1-S/G2 phases of the cell cycle. Recent studies of glioblastoma (GBM) biopsies, a brain tumor that is notorious for its aggressive growth and resistance ...
Matthew R. Sarkisian, Matthew R. Sarkisian, Susan L. Semple-Rowland   +2 more
doaj   +5 more sources

Primary cilia and lipid raft dynamics [PDF]

Open Biology, 2021
Primary cilia, antenna-like structures of the plasma membrane, detect various extracellular cues and transduce signals into the cell to regulate a wide range of functions.
Yuhei Nishimura, Daishi Yamakawa, Katsunori Uchida, Takashi Shiromizu, Masatoshi Watanabe, Masaki Inagaki   +5 more
doaj   +3 more sources

Lengthening primary cilia enhances cellular mechanosensitivity [PDF]

European Cells & Materials, 2017
The primary cilium is a mechanosensor in a variety of mammalian cell types, initiating and directing intracellular signalling cascades in response to external stimuli.
M Spasic, CR Jacobs
doaj   +3 more sources

Rediscovering Primary Cilia in Pancreatic Islets [PDF]

Diabetes & Metabolism Journal, 2023
Primary cilia are microtubule-based sensory and signaling organelles on the surfaces of most eukaryotic cells. Despite their early description by microscopy studies, islet cilia had not been examined in the functional context until recent decades.
Eun Young Lee, Jing W. Hughes
doaj   +3 more sources

Visualizing renal primary cilia [PDF]

Nephrology, 2013
AbstractRenal primary cilia are microscopic sensory organelles found on the apical surface of epithelial cells of the nephron and collecting duct. They are based upon a microtubular cytoskeleton, bounded by a specialized membrane, and contain an array of proteins that facilitate their assembly, maintenance and function.
Deane, James, Verghese, Elizabeth, Martelotto, Luciano, Cain, Jason, Galtseva, Alya, Rosenblum, Norman, Watkins, David, Rocardo, Shanon   +7 more
openaire   +4 more sources

Primary cilia are not calcium-responsive mechanosensors [PDF]

Nature, 2016
Primary cilia are solitary, generally non-motile, hair-like protrusions that extend from the surface of cells between cell divisions. Their antenna-like structure leads naturally to the assumption that they sense the surrounding environment, the most common hypothesis being sensation of mechanical force through calcium-permeable ion channels within the
Delling, M., Indzhykulian, A. A., Liu, X., Liu, Y., Xie, T., Corey, D. P., Clapham, D. E.   +6 more
openaire   +5 more sources

The Roles of Primary Cilia in Cardiovascular Diseases [PDF]

Cells, 2018
Primary cilia are microtubule-based organelles found in most mammalian cell types. Cilia act as sensory organelles that transmit extracellular clues into intracellular signals for molecular and cellular responses.
Rajasekharreddy Pala, Maha Jamal, Qamar Alshammari, Surya M. Nauli   +3 more
doaj   +4 more sources

Primary Cilia and Atherosclerosis [PDF]

Frontiers in Physiology, 2021
In artery tree, endothelial function correlates with the distribution of shear stress, a dragging force generated by flowing blood. In laminar shear stress areas, endothelial cells (ECs) are available to prevent atherosclerosis, however, ECs in disturbed shear stress sites are featured with proinflammation and atherogenesis.
Zhi-Mei Wang, Xiao-Fei Gao, Jun-Jie Zhang, Shao-Liang Chen   +3 more
openaire   +3 more sources

Structure, interaction and nervous connectivity of beta cell primary cilia [PDF]

Nature Communications
Primary cilia are sensory organelles present in many cell types, partaking in various signaling processes. Primary cilia of pancreatic beta cells play pivotal roles in paracrine signaling and their dysfunction is linked to diabetes.
Andreas Müller, Nikolai Klena, Song Pang, Leticia Elizabeth Galicia Garcia, Oleksandra Topcheva, Solange Aurrecoechea Duran, Davud Sulaymankhil, Monika Seliskar, Hassan Mziaut, Eyke Schöniger, Daniela Friedland, Nicole Kipke, Susanne Kretschmar, Carla Münster, Jürgen Weitz, Marius Distler, Thomas Kurth, Deborah Schmidt, Harald F. Hess, C. Shan Xu, Gaia Pigino, Michele Solimena   +21 more
doaj   +2 more sources