Results 11 to 20 of about 42,278 (249)

The Roles of Primary Cilia in Cardiovascular Diseases

Cells, 2018
Primary cilia are microtubule-based organelles found in most mammalian cell types. Cilia act as sensory organelles that transmit extracellular clues into intracellular signals for molecular and cellular responses.
Rajasekharreddy Pala, Maha Jamal, Qamar Alshammari, Surya M. Nauli   +3 more
doaj   +3 more sources

Primary cilia in cancer: structures, functions, mechanisms, and therapeutic implications [PDF]

Cancer Biology & Medicine
Primary cilia, microtubule-based organelles protruding from the surfaces of most eukaryotic cells, have critical roles in maintaining cellular homeostasis, by sensing, transducing, and transmitting diverse extracellular and intracellular signals through ...
Miaomiao Zheng, Jun Zhou, Yijie Wang
doaj   +2 more sources

Fragmentation of kidney epithelial cell primary cilia occurs by cisplatin and these cilia fragments are excreted into the urine

Redox Biology, 2019
The primary cilium, which protrudes from the cell surface, is associated with the pathogenesis of various diseases, including acute kidney injury (AKI). Primary cilium length dynamically changes during the progression of diseases.
Min Jung Kong, Sang Hong Bak, Ki-Hwan Han, Jee In Kim, Jeen-Woo Park, Kwon Moo Park   +5 more
doaj   +3 more sources

Growth factor-independent mTORC1 signaling promotes primary cilia length via suppression of autophagy [PDF]

iScience
Summary: The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1), a sensor of growth signals that control cell growth, has been studied mainly in proliferating cells.
Jong Shin, Khaled Tighanimine, Yann Cormerais, Dean M. Rosenthal, Pratima Niroula, Samuel C. Lapp, Krystle C. Kalafut, Madi Y. Cisse, Sandra Schrötter, Brendan D. Manning   +9 more
doaj   +2 more sources

Application of bioactive materials primary cilia as a novel delivery vehicle [PDF]

Bioactive Materials
Primary cilia are hair-like structured cell organelles functioning as cellular antennae with chemosensory and mechanosensory roles. Dysfunction of cilia results in ciliopathies, including renovascular diseases (polycystic kidneys, hypertension, aneurysm),
Ayan K. Barui, Farideh Amirrad, Vansh Goel, Sharareh Ohadi, Rajasekharreddy Pala, Ashraf M. Mohieldin, Andromeda M. Nauli, Surya M. Nauli   +7 more
doaj   +2 more sources

Primary cilia in growth plates orchestrate long bone development [PDF]

Fundamental Research
The growth plate plays a crucial role in long bone development and elongation, housing stem cells that contribute to bone formation. This study investigates the role of primary cilia, specialized organelles that regulate stem cell fate, in the ...
Lei Zhang, Xiaoqiao Xu, Dike Tao, Xinyu Li, Pingping Niu, Xuyan Gong, Gongchen Li, Mengfei Yu, Yao Sun   +8 more
doaj   +2 more sources

Calprotectin: An Ignored Biomarker of Neutrophilia in Pediatric Respiratory Diseases

Children, 2021
Calprotectin (CP) is a non-covalent heterodimer formed by the subunits S100A8 (A8) and S100A9 (A9). When neutrophils become activated, undergo disruption, or die, this abundant cytosolic neutrophil protein is released.
Grigorios Chatziparasidis, Ahmad Kantar
doaj   +1 more source

Vaping in Asthmatic Adolescents: Time to Deal with the Elephant in the Room

Children, 2022
Adolescence is a period characterized by developmental, psychological, and psychosocial alterations, with a major impact on youths’ attitudes and perceptions.
Grigorios Chatziparasidis, Ahmad Kantar
doaj   +1 more source

Primary cilia and lipid raft dynamics

Open Biology, 2021
Primary cilia, antenna-like structures of the plasma membrane, detect various extracellular cues and transduce signals into the cell to regulate a wide range of functions.
Yuhei Nishimura, Daishi Yamakawa, Katsunori Uchida, Takashi Shiromizu, Masatoshi Watanabe, Masaki Inagaki   +5 more
doaj   +1 more source

Recent advances in primary cilia in bone metabolism

Frontiers in Endocrinology, 2023
Primary cilia are microtubule-based organelles that are widespread on the cell surface and play a key role in tissue development and homeostasis by sensing and transducing various signaling pathways.
Fenfen Lian, Hui Li, Yuwei Ma, Rui Zhou, Wei Wu   +4 more
doaj   +1 more source