Results 41 to 50 of about 9,240 (177)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Motile ciliogenesis and the mitotic prism

Biology of the Cell, 2019
AbstractMotile cilia of epithelial multiciliated cells transport vital fluids along organ lumens to promote essential respiratory, reproductive and brain functions. Progenitors of multiciliated cells undergo massive and coordinated organelle remodelling during their differentiation for subsequent motile ciliogenesis.
Al Jord, Adel, Spassky, Nathalie, Meunier, Alice   +2 more
openaire   +3 more sources

Coordination of Rab8 and Rab11 in primary ciliogenesis [PDF]

Proceedings of the National Academy of Sciences, 2010
Primary cilia are microtubule-based membrane projections located at the surface of many cells. Defects in primary cilia formation have been implicated in a number of genetic disorders, such as Bardet-Biedl Syndrome and Polycystic Kidney Disease.
Andreas, Knödler, Shanshan, Feng, Jian, Zhang, Xiaoyu, Zhang, Amlan, Das, Johan, Peränen, Wei, Guo   +6 more
openaire   +2 more sources

Lack of a Retinal Phenotype in a Syne-2/Nesprin-2 Knockout Mouse Model

Cells, 2019
Syne-2 (also known as Nesprin-2) is a member of a family of proteins that are found primarily in the outer nuclear membrane, as well as other subcellular compartments.
Nathalie Falk, Anneka Joachimsthaler, Kristin Kessler, Uwe Thorsten Lux, Angelika Anna Noegel, Jan Kremers, Johann Helmut Brandstätter, Andreas Gießl   +7 more
doaj   +1 more source

Tissue-specific requirement of sodium channel and clathrin linker 1 (Sclt1) for ciliogenesis during limb development

Frontiers in Cell and Developmental Biology, 2022
Primary cilia have essential roles as signaling centers during development and adult homeostasis. Disruption of ciliary structure or function causes congenital human disorders called ciliopathies.
Hankyu Lee, Hankyu Lee, Kyeong-Hye Moon, Kyeong-Hye Moon, Jieun Song, Jieun Song, Suyeon Je, Suyeon Je, Jinwoong Bok, Jinwoong Bok, Jinwoong Bok, Hyuk Wan Ko, Hyuk Wan Ko   +12 more
doaj   +1 more source

Streamlining Diagnosis of Bardet–Biedl Syndrome: New Diagnostic Algorithm With Updated Criteria

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Considerable advances have been made in our understanding of Bardet–Biedl syndrome (BBS), particularly in its core clinical features and molecular genetics, warranting an update to the existing diagnostic criteria framework. Using a rigorous, evidence‐based, and consensus‐driven process, a multidisciplinary group of international experts and ...
Jeremy J. Pomeroy, Jesse Richards, Brooke R. Sweeney, Seema Kumar, Katie E. Queen, Joshua Zaritsky, Carl H. Cramer, Elias I. Traboulsi, Brittni A. Scruggs, Erica E. Davis, Ekaterina Keifer, Emma McGibbon, Timothy Ogden, Bendert De Graaf, Tonia Hymers, Elizabeth Forsythe, Philip Beales   +16 more
wiley   +1 more source

A Kinesin in Command of Primary Ciliogenesis [PDF]

Cell, 2011
Primary cilia sense extracellular cues and in response transmit signals required for development and tissue homeostasis. A new study by Kobayashi et al. (2011) reports that the kinesin Kif24 controls the formation of primary cilia by restricting the nucleation of cilia at centrioles.
openaire   +2 more sources

Functional interaction between autophagy and ciliogenesis [PDF]

Nature, 2013
Nutrient deprivation is a stimulus shared by both autophagy and the formation of primary cilia. The recently discovered role of primary cilia in nutrient sensing and signalling motivated us to explore the possible functional interactions between this signalling hub and autophagy.
Pampliega, Olatz, Orhon, Idil, Patel, Bindi, Sridhar, Sunandini, Díaz-Carretero, Antonio, Beau, Isabelle, Codogno, Patrice, Satir, Birgit, Satir, Peter, Cuervo, Ana Maria   +9 more
openaire   +2 more sources

Structure of the ciliogenesis-associated CPLANE complex

Science Advances, 2022
Dysfunctional cilia cause pleiotropic human diseases termed ciliopathies. These hereditary maladies are often caused by defects in cilia assembly, a complex event that is regulated by the ciliogenesis and planar polarity effector (CPLANE) proteins Wdpcp, Inturned, and Fuzzy.
Gerasimos Langousis, Simone Cavadini, Niels Boegholm, Esben Lorentzen, Georg Kempf, Patrick Matthias   +5 more
openaire   +3 more sources

Microtubule Destabilizing Kinesins: A Historical Perspective and Thoughts for the Future

Cytoskeleton, EarlyView.
ABSTRACT The microtubule cytoskeleton plays critical roles in multiple cellular processes such as mitotic spindle assembly and chromosome segregation. Cells contain a number of microtubule‐associated proteins that regulate microtubule dynamics both temporally and spatially in cells. The microtubule depolymerizing kinesins include members of the Kinesin‐
Claire E. Walczak
wiley   +1 more source