Results 41 to 50 of about 11,577 (216)
A ciliopathy complex builds distal appendages to initiate ciliogenesis [PDF]
, 2021 Cells inherit two centrioles, the older of which is uniquely capable of generating a cilium. Using proteomics and superresolved imaging, we identify a module that we term DISCO (distal centriole complex).
Garcia-Verdugo, Jose +35 more
core +1 more source
Cyclin-dependent kinase control of motile ciliogenesis [PDF]
, 2018 Cycling cells maintain centriole number at precisely two per cell in part by limiting their duplication to S phase under the control of the cell cycle machinery.
Axelrod, Jeffrey D. +7 more
core +2 more sources
Spectrin-based membrane skeleton supports ciliogenesis [PDF]
, 2019 Cilia are remarkable cellular devices that power cell motility and transduce extracellular signals. To assemble a cilium, a cylindrical array of 9 doublet microtubules push out an extension of the plasma membrane.
Zhongyun Xie +25 more
core +1 more source
NRF2 and Primary Cilia: An Emerging Partnership
Antioxidants, 2020 When not dividing, many cell types target their centrosome to the plasma membrane, where it nucleates assembly of a primary cilium, an antenna-like signaling structure consisting of nine concentric microtubule pairs surrounded by membrane.
Ana Martin-Hurtado +3 more
doaj +1 more source
Ciliogenesis is Not Directly Regulated by LRRK2 Kinase Activity in Neurons [PDF]
, 2021 Mutations in the Leucine-rich repeat kinase 2 (LRRK2) gene are the most prevalent cause of familial Parkinson's disease (PD). The increase in LRRK2 kinase activity observed in the pathogenic G2019S mutation is important for PD development.
Joo-Eun Lee +24 more
core +1 more source
Cells, 2019 Centriolar satellites are non-membrane cytoplasmic granules that deliver proteins to centrosome during centrosome biogenesis and ciliogenesis. Centriolar satellites are highly dynamic during cell cycle or ciliogenesis and how they are regulated remains ...
Pengtao Wang +10 more
doaj +1 more source
Nature Communications, 2021 Ciliogenesis is a tightly regulated process, although the role of selective autophagy is unclear. Here, the authors show NIMA-related kinase 9 controls actin network stabilization and subsequently ciliogenesis by targeting myosin MYH9 for autophagic ...
Yasuhiro Yamamoto +5 more
doaj +1 more source
Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking [PDF]
, 2018 Primary cilia exert a profound impact on cell signalling and cell cycle progression. Recently, actin cytoskeleton destabilization has been recognized as a dominant inducer of ciliogenesis, but the exact mechanisms regulating ciliogenesis remain poorly ...
Joon Kim +7 more
core +1 more source
The Cdc14B phosphatase contributes to ciliogenesis in zebrafish [PDF]
Development, 2011 Progression through the cell cycle relies on oscillation of cyclin-dependent kinase (Cdk) activity. One mechanism for downregulating Cdk signaling is to activate opposing phosphatases. The Cdc14 family of phosphatases counteracts Cdk1 phosphorylation in diverse organisms to allow proper exit from mitosis and cytokinesis.
Aurélie, Clément +2 more
openaire +2 more sources
Primary Cilia Formation Does Not Rely on WNT/β-Catenin Signaling
Frontiers in Cell and Developmental Biology, 2021 Primary cilia act as crucial regulators of embryo development and tissue homeostasis. They are instrumental for modulation of several signaling pathways, including Hedgehog, WNT, and TGF-β.
Ondrej Bernatik +4 more
doaj +1 more source