Results 1 to 10 of about 83,543 (230)
Actin nucleation at the centrosome controls lymphocyte polarity
Nature Communications, 2016 Cell polarity is marked by re-orientation of the centrosome, but the mechanisms governing centrosome polarization are poorly understood. Here Obino et al.
Laurent Blanchoin +2 more
exaly +3 more sources
Centrosome-kinase fusions promote oncogenic signaling and disrupt centrosome function in myeloproliferative neoplasms. [PDF]
PLoS ONE, 2014 Chromosomal translocations observed in myeloproliferative neoplasms (MPNs) frequently fuse genes that encode centrosome proteins and tyrosine kinases. This causes constitutive activation of the kinase resulting in aberrant, proliferative signaling.
Joanna Y Lee +3 more
doaj +2 more sources
Site-specific phosphorylation of ZYG-1 regulates ZYG-1 stability and centrosome number
iScience, 2023 Summary: Spindle bipolarity is critical for genomic integrity. As centrosome number often dictates bipolarity, tight control of centrosome assembly is vital for faithful cell division.
Jeffrey C. Medley +8 more
doaj +1 more source
Scientific Reports, 2023 Primary cilia are key regulators of embryo development and tissue homeostasis. However, their mechanisms and functions, particularly in the context of human cells, are still unclear.
Lucia Binó, Lukáš Čajánek
doaj +1 more source
A catalog of numerical centrosome defects in epithelial ovarian cancers
EMBO Molecular Medicine, 2022 Centrosome amplification, the presence of more than two centrosomes in a cell is a common feature of most human cancer cell lines. However, little is known about centrosome numbers in human cancers and whether amplification or other numerical aberrations
Jean‐Philippe Morretton +25 more
doaj +1 more source
Rab11 endosomes and Pericentrin coordinate centrosome movement during pre-abscission in vivo
Life Science Alliance, 2022 Cell division completes when the two daughter cells move their oldest centrosome towards the cytokinetic bridge, which is then cleaved during abscission.
Nikhila Krishnan +7 more
doaj +1 more source
iScience, 2023 Summary: Centrosomal protein 120 (CEP120) is a 120 kDa centrosome protein that plays an important role in centrosome replication. Overexpression of CEP120 can lead to centrosome duplicate abnormality, which is closely associated with tumorigenesis and ...
Chenggang Zhang +11 more
doaj +1 more source
Centrosome-phagy: implications for human diseases
Cell & Bioscience, 2021 Autophagy is a prominent mechanism to preserve homeostasis and the response to intracellular or extracellular stress. Autophagic degradation can be selectively targeted to dysfunctional subcellular compartments.
Qi Wu +4 more
doaj +1 more source
Cells, 2022 The Golgi complex of mammalian cells is organized in a ribbon-like structure often closely associated with the centrosome during interphase. Conversely, the Golgi complex assumes a fragmented and dispersed configuration away from the centrosome during ...
Fabiola Mascanzoni +2 more
doaj +1 more source
Cep295 is a conserved scaffold protein required for generation of a bona fide mother centriole
Nature Communications, 2016 Newly formed centrioles mature into functional mother centrioles. Here the authors show that the scaffolding protein Cep295 is recruited to the procentriole assembly site and assists daughter centriole assembly and daughter-to-mother centriole conversion.
Yuki Tsuchiya +4 more
doaj +1 more source