The Dictyostelium Centrosome [PDF]
Cells, 2021 The centrosome of Dictyostelium amoebae contains no centrioles and consists of a cylindrical layered core structure surrounded by a corona harboring microtubule-nucleating γ-tubulin complexes. It is the major centrosomal model beyond animals and yeasts.
Ralph Gräf +4 more
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Choreography of the centrosome [PDF]
Heliyon, 2020 More than a century ago, the centrosome was discovered and described as "the true division organ of the cell". Electron microscopy revealed that a centrosome is an amorphous structure or pericentriolar protein matrix that surrounds a pair of well-organized centrioles.
Alvarado Kristensson, Maria
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Centrosome-Associated NDR Kinase Regulates Centrosome Duplication [PDF]
Molecular Cell, 2007 Human NDR kinases are upregulated in some cancer types, yet their functions still remain undefined. Here, we report the first known function of a mammalian NDR kinase by demonstrating that human NDR directly contributes to centrosome duplication. A subpopulation of endogenous NDR localizes to centrosomes in a cell-cycle-dependent manner. Overexpression
Hergovich, Alexander +3 more
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FEBS Letters, 2002 The centrosome is the major microtubule‐organizing center of animal cells. It influences cell shape and polarity and directs the formation of the bipolar mitotic spindle. Numerical and structural centrosome aberrations have been implicated in disease, notably cancer.
Meraldi, P., Nigg, E. A.
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LRRC45 Is a Centrosome Linker Component Required for Centrosome Cohesion
Cell Reports, 2013 During interphase, centrosomes are connected by a proteinaceous linker between the proximal ends of the centrioles, which is important for the centrosomes to function as a single microtubule-organizing center. However, the composition and regulation of centrosomal linker remain largely unknown.
Runsheng He +5 more
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Centrosomal and Non-centrosomal Functions Emerged through Eliminating Centrosomes
Cell Structure and Function, 2020 Centrosomes are highly conserved organelles that act as the major microtubule-organizing center (MTOC) in animal somatic cells. Through their MTOC activity, centrosomes play various roles throughout the cell cycle, such as supporting cell migration in interphase and spindle organization and positioning in mitosis.
Takeda, Yutaka +3 more
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Rootletin forms centriole-associated filaments and functions in centrosome cohesion [PDF]
, 2005 After duplication of the centriole pair during S phase, the centrosome functions as a single microtubule-organizing center until the onset of mitosis, when the duplicated centrosomes separate for bipolar spindle formation.
Erich A. Nigg +14 more
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Correction to "The Variant Senescence-Associated Secretory Phenotype Induced by Centrosome Amplification Constitutes a Pathway That Activates Hypoxia-Inducible Factor-1α". [PDF]
Aging CellAging Cell, Volume 25, Issue 6, June 2026.
europepmc +2 more sources
Investigating the cellular and molecular mechanisms involved in establishing and maintaining centrosome asymmetry in Drosophila neuroblasts [PDF]
, 2015 Centrosome asymmetry has been implicated in stem cell fate maintenance in both flies and vertebrates. Drosophila neuroblasts, the neural precursors of the fly’s central nervous system, contain molecularly and physically asymmetric centrosomes.
Nair, Anjana Ramdas
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Centrosome heterogeneity in stem cells regulates cell diversity. [PDF]
, 2022 Stem cells are at the source of creating cellular diversity. Multiple mechanisms, including basic cell biological processes, regulate their fate. The centrosome is at the core of many stem cell functions and recent work highlights the association of ...
Camargo Ortega, G. +3 more
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