The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion [PDF]
, 2000 Duplicating centrosomes are paired during interphase, but are separated at the onset of mitosis. Although the mechanisms controlling centrosome cohesion and separation are important for centrosome function throughout the cell cycle, they remain poorly ...
Fry, A. M. +14 more
core +1 more source
Centrosome Biology: The Ins and Outs of Centrosome Assembly [PDF]
Current Biology, 2015 As a microtubule-organizing center, the centrosome undergoes a dramatic increase in size - via expansion of the pericentriolar material - during mitosis. Recent work reveals shared assembly properties of a protein scaffold that facilitates and supports this expansion, a process critical to spindle assembly.
Prosser, Suzanna L. +1 more
openaire +2 more sources
Bimodal Binding of STIL to Plk4 Controls Proper Centriole Copy Number
Cell Reports, 2018 Summary: The number of centrioles is tightly controlled to ensure bipolar spindle assembly, which is a prerequisite to maintain genome integrity. However, our understanding of the fundamental principle that governs the formation of a single procentriole ...
Midori Ohta +6 more
doaj +1 more source
The phosphorylation of PHF5A by TrkA-ERK1/2-ABL1 cascade regulates centrosome separation
Cell Death and Disease, 2023 During interphase, the newly duplicated pairs of centrosomes are held together by a centrosome linker, and the centrosome separation needs the disruption of this linker to induce the duplicated centrosomes separating into two distinct microtubule ...
Chen Song +10 more
doaj +1 more source
The Cep57-pericentrin module organizes PCM expansion and centriole engagement
Nature Communications, 2019 Centriole disengagement occurs towards mitotic exit and involves cleavage of pericentrin, a component of the pericentriolar material. Here the authors show that depletion of the centrosomal protein Cep57 leads to precocious centriole disengagement, and ...
Koki Watanabe +4 more
doaj +1 more source
Centrosome Biology: Polymer-Based Centrosome Maturation [PDF]
Current Biology, 2017 The molecular mechanisms that control how the centrosome increases in size and microtubule nucleation capacity during mitosis have remained elusive. Recent work using in vitro assays provide exciting clues as to how this may occur.
Gagan D, Gupta, Laurence, Pelletier
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IFT proteins spatially control the geometry of cleavage furrow ingression and lumen positioning
Nature Communications, 2017 Cytokinesis relies on central spindle organization and provides a spatial landmark for lumen formation. Here, the authors show that intraflagellar transport proteins are required for the localization of the cytokinetic regulator Aurora B and subsequent ...
Nicolas Taulet +8 more
doaj +1 more source
Kinetochore-generated pushing forces separate centrosomes during bipolar spindle assembly [PDF]
, 2009 In animal somatic cells, bipolar spindle formation requires separation of the centrosome-based spindle poles. Centrosome separation relies on multiple pathways, including cortical forces and antiparallel microtubule (MT) sliding, which are two activities
Winter, Jennifer R. +17 more
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Centrosome loss or amplification does not dramatically perturb global gene expression in Drosophila
Biology Open, 2012 Summary Centrosome defects are a common feature of many cancers, and they can predispose fly brain cells to form tumours. In flies, centrosome defects perturb the asymmetric division of the neural stem cells, but it is unclear how this might lead to ...
Janina Baumbach +2 more
doaj +1 more source
Centrosome-intrinsic mechanisms modulate centrosome integrity during fever [PDF]
, 2019 The centrosome is critical for cell division, ciliogenesis, membrane trafficking, and immunological synapse function. The immunological synapse is part of the immune response, which is often accompanied by fever/heat stress (HS). Here we provide evidence
Vertii, Anastassiia +3 more
core +1 more source