Results 21 to 30 of about 72,372 (185)
IFT proteins spatially control the geometry of cleavage furrow ingression and lumen positioning
Nature Communications, 2017 Cytokinesis relies on central spindle organization and provides a spatial landmark for lumen formation. Here, the authors show that intraflagellar transport proteins are required for the localization of the cytokinetic regulator Aurora B and subsequent ...
Nicolas Taulet +8 more
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Centrosome loss or amplification does not dramatically perturb global gene expression in Drosophila
Biology Open, 2012 Summary Centrosome defects are a common feature of many cancers, and they can predispose fly brain cells to form tumours. In flies, centrosome defects perturb the asymmetric division of the neural stem cells, but it is unclear how this might lead to ...
Janina Baumbach +2 more
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Choreography of the centrosome [PDF]
Heliyon, 2020 More than a century ago, the centrosome was discovered and described as "the true division organ of the cell". Electron microscopy revealed that a centrosome is an amorphous structure or pericentriolar protein matrix that surrounds a pair of well-organized centrioles.
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Centrosome-Associated NDR Kinase Regulates Centrosome Duplication [PDF]
Molecular Cell, 2007 Human NDR kinases are upregulated in some cancer types, yet their functions still remain undefined. Here, we report the first known function of a mammalian NDR kinase by demonstrating that human NDR directly contributes to centrosome duplication. A subpopulation of endogenous NDR localizes to centrosomes in a cell-cycle-dependent manner. Overexpression
Hergovich, Alexander +3 more
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The Identification and Functional Analysis of mRNA Localizing to Centrosomes
Frontiers in Cell and Developmental Biology, 2021 Centrosomes are multifunctional organelles tasked with organizing the microtubule cytoskeleton required for genome stability, intracellular trafficking, and ciliogenesis.
Hala Zein-Sabatto, Dorothy A. Lerit
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Cells, 2021 The timing of centrosome separation and the distance moved apart influence the formation of the bipolar spindle, affecting chromosome stability. Epidermal growth factor receptor (EGFR) signaling induces early centrosome separation through downstream G ...
Clara Reglero +4 more
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Proteins implicated in muscular dystrophy and cancer are functional constituents of the centrosome
Life Science Alliance, 2022 This study demonstrates that the muscular dystrophy-associated proteins dystrophin, utrophin, dysferlin, and calpain-3 localize to the centrosome and that their absence leads to excess centrosomes, compromised nuclear morphology, impaired centrosome ...
Lilli Winter +5 more
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FEBS Letters, 2002 The centrosome is the major microtubule‐organizing center of animal cells. It influences cell shape and polarity and directs the formation of the bipolar mitotic spindle. Numerical and structural centrosome aberrations have been implicated in disease, notably cancer.
Meraldi, P., Nigg, E. A.
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APC/CFZR-1 Controls SAS-5 Levels To Regulate Centrosome Duplication in Caenorhabditis elegans
G3: Genes, Genomes, Genetics, 2017 As the primary microtubule-organizing center, centrosomes play a key role in establishing mitotic bipolar spindles that secure correct transmission of genomic content.
Jeffrey C. Medley +3 more
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A Proximity Mapping Journey into the Biology of the Mammalian Centrosome/Cilium Complex
Cells, 2020 The mammalian centrosome/cilium complex is composed of the centrosome, the primary cilium and the centriolar satellites, which together regulate cell polarity, signaling, proliferation and motility in cells and thereby development and homeostasis in ...
Melis Dilara Arslanhan +2 more
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