Results 1 to 10 of about 327,045 (196)
Mitotic spindle membranes. [PDF]
Mol Biol CellThe mitotic spindle, which uses microtubules (MTs) and MT-based motor proteins to separate sister chromosomes prior to cell division, contains abundant membranes, organelles, and protein assemblies derived from the familiar interphase intracellular ...
Scholey JM.
europepmc +4 more sources
NuMA regulates mitotic spindle assembly, structural dynamics and function via phase separation
Nature Communications, 2021 Mitotic spindle assembly is required for proper cell division, but many underlying mechanisms remain unclear. Here, the authors show that NuMa undergoes liquid-liquid phase separation, condensing on spindle poles during mitotic entry and enriching ...
Chuanmao Zhang +2 more
exaly +3 more sources
Mechanobiology of the Mitotic Spindle. [PDF]
Developmental Cell, 2020 The mitotic spindle is a microtubule-based assembly that separates the chromosomes during cell division. As the spindle is basically a mechanical micro machine, the understanding of its functioning is constantly motivating the development of experimental
N. Pavin, I. Tolic
semanticscholar +5 more sources
Frontiers in Cell and Developmental Biology, 2021 The nuclear mitotic apparatus (NuMA) protein is well conserved in vertebrates, and dynamically changes its subcellular localization from the interphase nucleus to the mitotic/meiotic spindle poles and the mitotic cell cortex.
Tomomi Kiyomitsu, Susan Boerner
doaj +2 more sources
Concentrating on the mitotic spindle [PDF]
Journal of Cell Biology, 2015 In eukaryotes, the microtubule-based spindle drives chromosome segregation. In this issue, Schweizer et al. (2015; J. Cell Biol. http://dx.doi.org/10.1083/jcb.201506107) find that the spindle area is demarcated by a semipermeable organelle barrier ...
P. Maddox, Anna Ladouceur
semanticscholar +3 more sources
HMMR/RHAMM recruits SACK1D/FAM83D-CK1α complex at the mitotic spindle to control spindle alignment [PDF]
iScienceSummary: The SACK1D/FAM83D-CK1α complex assembles at the mitotic spindle to orchestrate proper spindle positioning and error-free progression through mitosis.
Tyrell N. Cartwright +7 more
doaj +2 more sources
Mechanisms of Mitotic Spindle Assembly [PDF]
Annual Review of Biochemistry, 2016 Life depends on cell proliferation and the accurate segregation of chromosomes, which are mediated by the microtubule (MT)-based mitotic spindle and ~200 essential MT-associated proteins.
S. Petry
semanticscholar +3 more sources
Hedgehog signaling controls astral microtubules and mitotic spindle orientation in neural progenitors and iPSCs [PDF]
Frontiers in Cell and Developmental BiologyMitotic spindle orientation is crucial for cell fate determination and tissue organization. Although the intracellular machinery governing spindle orientation is well characterized, whether and how secreted factors, such as morphogens, regulate this ...
Fengming Liu +8 more
doaj +2 more sources
Types of potentials in a mitotic spindle
Biochemistry and Biophysics Reports, 2021 The dynamics of a mitotic spindle is very important to understand if the functioning of mitosis has to be understood and defined very accurately. There are a number of forces involved in such a process.
Yelena Nemchen +2 more
doaj +3 more sources
Thirty years of search and capture: The complex simplicity of mitotic spindle assembly
Journal of Cell Biology, 2015 Cell division is enacted by a microtubule-based, self-assembling macromolecular machine known as the mitotic spindle. In 1986, Kirschner and Mitchison proposed that by undergoing dynamic cycles of growth and disassembly, microtubules search for ...
Rebecca Heald +2 more
exaly +2 more sources