Mechanobiology of the Mitotic Spindle [PDF]
Developmental Cell, 2021 The mitotic spindle is a microtubule-based assembly that separates the chromosomes during cell division. As the spindle is basically a mechanical micro machine, the understanding of its functioning is constantly motivating the development of experimental approaches based on mechanical perturbations, which are complementary to and work together with the
Nenad Pavin, Iva Tolic
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Mitotic spindle membranes. [PDF]
Mol Biol CellThe mitotic spindle, which uses microtubules (MTs) and MT-based motor proteins to separate sister chromosomes prior to cell division, contains abundant membranes, organelles, and protein assemblies derived from the familiar interphase intracellular membrane network.
Scholey JM.
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HMMR/RHAMM recruits SACK1D/FAM83D-CK1α complex at the mitotic spindle to control spindle alignment [PDF]
iScienceSummary: The SACK1D/FAM83D-CK1α complex assembles at the mitotic spindle to orchestrate proper spindle positioning and error-free progression through mitosis.
Tyrell N. Cartwright +7 more
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Hedgehog signaling controls astral microtubules and mitotic spindle orientation in neural progenitors and iPSCs [PDF]
Frontiers in Cell and Developmental BiologyMitotic spindle orientation is crucial for cell fate determination and tissue organization. Although the intracellular machinery governing spindle orientation is well characterized, whether and how secreted factors, such as morphogens, regulate this ...
Fengming Liu +8 more
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NuMA regulates mitotic spindle assembly, structural dynamics and function via phase separation
Nature Communications, 2021 Mitotic spindle assembly is required for proper cell division, but many underlying mechanisms remain unclear. Here, the authors show that NuMa undergoes liquid-liquid phase separation, condensing on spindle poles during mitotic entry and enriching ...
Chuanmao Zhang, He Ren, Guangwei Xin
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Types of potentials in a mitotic spindle
Biochemistry and Biophysics Reports, 2021 The dynamics of a mitotic spindle is very important to understand if the functioning of mitosis has to be understood and defined very accurately. There are a number of forces involved in such a process.
Yelena Nemchen +2 more
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Palmitoylated importin α regulates mitotic spindle orientation through interaction with NuMA [PDF]
EMBO ReportsRegulation of cell division orientation is a fundamental process critical to differentiation and tissue homeostasis. Microtubules emanating from the mitotic spindle pole bind a conserved complex of proteins at the cell cortex which orients the spindle ...
Patrick James Sutton +2 more
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CAMSAP2 is required for bridging fiber assembly to ensure mitotic spindle assembly and chromosome segregation in human epithelial Caco-2 cells. [PDF]
PLoS ONEIn mammalian epithelial cells, cytoplasmic microtubules are mainly non-centrosomal, through the functions of the minus-end binding proteins CAMSAP2 and CAMSAP3.
Naoko Nishizawa +4 more
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Timely Endocytosis of Cytokinetic Enzymes Prevents Premature Spindle Breakage during Mitotic Exit. [PDF]
PLoS Genetics, 2016 Cytokinesis requires the spatio-temporal coordination of membrane deposition and primary septum (PS) formation at the division site to drive acto-myosin ring (AMR) constriction.
Cheen Fei Chin +6 more
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The structure of the mitotic spindle and nucleolus during mitosis in the amebo-flagellate Naegleria. [PDF]
PLoS ONE, 2012 Mitosis in the amebo-flagellate Naegleria pringsheimi is acentrosomal and closed (the nuclear membrane does not break down). The large central nucleolus, which occupies about 20% of the nuclear volume, persists throughout the cell cycle.
Charles J Walsh
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