Results 31 to 40 of about 327,045 (196)
Current Biology, 2019 A functional bipolar spindle is essential to segregate chromosomes correctly during mitosis. Across organisms and cell types, spindle architecture should be optimized to promote error-free divisions. However, it remains to be investigated whether mitotic
Diana Vargas-Hurtado +8 more
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Cell Division, 2019 Background At the onset of mitosis, the centrosome expands and matures, acquiring enhanced activities for microtubule nucleation and assembly of a functional bipolar mitotic spindle.
Chieh-Ting Fang +3 more
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Mitotic Spindle Assembly in Land Plants: Molecules and Mechanisms
Biology, 2017 In textbooks, the mitotic spindles of plants are often described separately from those of animals. How do they differ at the molecular and mechanistic levels?
Moé Yamada, Gohta Goshima
semanticscholar +1 more source
Mechanisms and Molecules of the Mitotic Spindle [PDF]
Current Biology, 2004 In all eukaryotes, morphogenesis of the microtubule cytoskeleton into a bipolar spindle is required for the faithful transmission of the genome to the two daughter cells during division. This process is facilitated by the intrinsic polarity and dynamic properties of microtubules and involves many proteins that modulate microtubule organization and ...
Gadde, Sharat, Heald, Rebecca
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Life Science Alliance, 2023 Using microinjection approaches in Drosophila embryos, Araújo et al reveal that acute disruption of the ER at centrosome-proximal sites perturbs the architecture of the mitotic spindle, with a direct impact on nuclear positioning.
Margarida Araújo +4 more
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Smurf2 as a novel mitotic regulator: From the spindle assembly checkpoint to tumorigenesis
Cell Division, 2009 The execution of the mitotic program with high fidelity is dependent upon precise spatiotemporal regulation of posttranslational protein modifications.
Moore Finola E +3 more
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USP11 deubiquitinates RAE1 and plays a key role in bipolar spindle formation. [PDF]
PLoS ONE, 2018 Correct segregation of the mitotic chromosomes into daughter cells is a highly regulated process critical to safeguard genome stability. During M phase the spindle assembly checkpoint (SAC) ensures that all kinetochores are correctly attached before its ...
Anna Stockum +2 more
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Protein Phosphatase 2A (PP2A) Regulates EG5 to Control Mitotic Progression
Scientific Reports, 2017 EG5 (KIF11) is a member of the kinesin-like protein family involved in centrosome separation and bipolar spindle formation. When a cell enters mitosis, CDK1 phosphorylates EG5 at Thr926 and promotes EG5 localization on the mitotic spindle which drives ...
Yang Liu +9 more
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Asymmetry of the budding yeast Tem1 GTPase at spindle poles is required for spindle positioning but not for mitotic exit. [PDF]
PLoS Genetics, 2015 The asymmetrically dividing yeast S. cerevisiae assembles a bipolar spindle well after establishing the future site of cell division (i.e., the bud neck) and the division axis (i.e., the mother-bud axis).
Ilaria Scarfone +5 more
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Matrin3 regulates mitotic spindle dynamics by controlling alternative splicing of CDC14B
Cell Reports, 2023 Summary: Matrin3 is an RNA-binding protein that regulates diverse RNA-related processes, including mRNA splicing. Although Matrin3 has been intensively studied in neurodegenerative diseases, its function in cancer remains unclear. Here, we report Matrin3-
Bruna R. Muys +13 more
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