Results 31 to 40 of about 198,084 (294)
PLoS Genetics, 2023 To prevent chromosome mis-segregation, a surveillance mechanism known as the spindle checkpoint delays the cell cycle if kinetochores are not attached to spindle microtubules, allowing the cell additional time to correct improper attachments.
Anne MacKenzie +2 more
doaj +1 more source
Prime movers : mechanochemistry of mitotic kinesins [PDF]
, 2014 Mitotic spindles are self-organizing protein machines that harness teams of multiple force generators to drive chromosome segregation. Kinesins are key members of these force-generating teams.
Cross, R. A., McAinsh, Andrew D.
core +1 more source
Mitotic spindle proteomics in Chinese hamster ovary cells.
PLoS ONE, 2011 Mitosis is a fundamental process in the development of all organisms. The mitotic spindle guides the cell through mitosis as it mediates the segregation of chromosomes, the orientation of the cleavage furrow, and the progression of cell division.
Mary Kate Bonner +5 more
doaj +1 more source
Fission yeast bub1 is a mitotic centromere protein essential for the spindle checkpoint and the preservation of correct ploidy through mitosis [PDF]
, 1998 The spindle checkpoint ensures proper chromosome segregation by delaying anaphase until all chromosomes are correctly attached to the mitotic spindle.
Javerzat, Jean-Paul +8 more
core +1 more source
Cell Division, 2019 Background At the onset of mitosis, the centrosome expands and matures, acquiring enhanced activities for microtubule nucleation and assembly of a functional bipolar mitotic spindle.
Chieh-Ting Fang +3 more
doaj +1 more source
Mechanisms and Molecules of the Mitotic Spindle [PDF]
Current Biology, 2004 In all eukaryotes, morphogenesis of the microtubule cytoskeleton into a bipolar spindle is required for the faithful transmission of the genome to the two daughter cells during division. This process is facilitated by the intrinsic polarity and dynamic properties of microtubules and involves many proteins that modulate microtubule organization and ...
Gadde, Sharat, Heald, Rebecca
openaire +2 more sources
Length-dependent anisotropic scaling of spindle shape [PDF]
, 2014 Spindle length varies dramatically across species and during early development to segregate chromosomes optimally. Both intrinsic factors, such as regulatory molecules, and extrinsic factors, such as cytoplasmic volume, determine spindle length scaling ...
Sébastien Besson +5 more
core +1 more source
Life Science Alliance, 2023 Using microinjection approaches in Drosophila embryos, Araújo et al reveal that acute disruption of the ER at centrosome-proximal sites perturbs the architecture of the mitotic spindle, with a direct impact on nuclear positioning.
Margarida Araújo +4 more
doaj +1 more source
Latrunculin A delays anaphase onset in fission yeast by disrupting an ase1-independent pathway controlling mitotic spindle stability [PDF]
, 2008 It has been proposed previously that latrunculin A, an inhibitor of actin polymerization, delays the onset of anaphase by causing spindle misorientation in fission yeast.
Meadows, John C., Millar, Jonathan B. A.
core +1 more source
Smurf2 as a novel mitotic regulator: From the spindle assembly checkpoint to tumorigenesis
Cell Division, 2009 The execution of the mitotic program with high fidelity is dependent upon precise spatiotemporal regulation of posttranslational protein modifications.
Moore Finola E +3 more
doaj +1 more source