Results 31 to 40 of about 130,672 (286)

Developmental expression of 4-repeat-Tau induces neuronal aneuploidy in Drosophila tauopathy models [PDF]

, 2017
Tau-mediated neurodegeneration in Alzheimer's disease and tauopathies is generally assumed to start in a normally developed brain. However, several lines of evidence suggest that impaired Tau isoform expression during development could affect mitosis and
Amouyel, Philippe, Bauderlique, Hélène, Bellen, Hugo J, Bongiovanni, Antonino, Callaerts, Patrick, Demiautte, Florie, Dermaut, Bart, Dourlen, Pierre, Dupont, Cloé, Gistelinck, Marc, Lafont, Frank, Lambert, Jean-Charles, Link, Nichole, Malmanche, Nicolas, Moechars, Dieder, Royou, Anne, Vanden Broeck, Lies, Werkmeister, Elisabeth   +17 more
core   +1 more source

The mitotic spindle checkpoint [PDF]

Current Biology, 2001
Fantastic progress has been made in understanding the spindle checkpoint, the guardian of balanced chromosome segregation. However, several basic questions and many details remain to be worked out. In the meantime, the use of chimeric fluorescent proteins and ever better imaging technology has enhanced the stunning videos of mitosis made today ...
openaire   +2 more sources

Mitotic spindle proteomics in Chinese hamster ovary cells.

PLoS ONE, 2011
Mitosis is a fundamental process in the development of all organisms. The mitotic spindle guides the cell through mitosis as it mediates the segregation of chromosomes, the orientation of the cleavage furrow, and the progression of cell division.
Mary Kate Bonner, Daniel S Poole, Tao Xu, Ali Sarkeshik, John R Yates, Ahna R Skop   +5 more
doaj   +1 more source

Prime movers : mechanochemistry of mitotic kinesins [PDF]

, 2014
Mitotic spindles are self-organizing protein machines that harness teams of multiple force generators to drive chromosome segregation. Kinesins are key members of these force-generating teams.
A Blangy, A Groen, A Hutterer, A Jannasch, A Karabay, A Toso, A Yildiz, AA Levesque, AB Asenjo, AC Groen, AE Butterfield, AF Huxley, AF Straight, AJ Roberts, AM Mulder, AM Saunders, Andrew McAinsh, AS Kashina, AS Khalil, B Gigant, B Owens, B Wickstead, BH Kwok, BH Kwok, BJ Grant, BT Schaar, C Antonio, C Hentrich, C Peters, C Thiede, C Wandke, CA Watts, CC Leduc, CE Walczak, CJ Lawrence, CK Hu, CL Parke, CL Rieder, CL Rieder, CM Whitehead, CTC Friel, CV Sindelar, CV Sindelar, D Vanneste, D Vanneste, DA Compton, E Doménech, E Karsenti, E Vladimirou, EG Sturgill, ER Hildebrandt, FJ Kull, FJ Kull, G Fink, GC Rogers, GJ Brouhard, GJ Gorbsky, GJPL Kops, H Aizawa, H Boleti, H Drechsler, H Funabiki, H Yardimci, HS Sardar, HS Sardar, HYK Kaan, I Brust-Mascher, I Brust-Mascher, I Minoura, IM Crevel, IM-TC Crevel, J Espeut, J Helenius, J Roostalu, J Roostalu, J Rosenblatt, J Stumpff, J Stumpff, J Stumpff, J Yajima, JC Cochran, JC Gatlin, JC Waters, JM Scholey, JPI Welburn, JR Aist, JR Cooper, JR McIntosh, JRJ Stout, JS Allingham, JS Weinger, K Hahlen, K Jaqaman, K Kaseda, K Kaseda, K Samejima, KE Gascoigne, KJ Verhey, KS Burbank, KW Wood, KW Wood, KY Lee, L Wordeman, LC Kapitein, LC Kapitein, LN Weaver, LR Sproul, M Braun, M Braun, M Glotzer, M Joshi, M Kikkawa, M Klejnot, M Mishima, M Nishiyama, M Wagenbach, MA Hoyt, MA Seeger, MC Alonso, ME Douglas, ME Tanenbaum, ME Tanenbaum, ME Tanenbaum, MI Mayr, MJ Korneev, ML Gupta, MT Valentine, MT Valentine, N Gudimchuk, N Hirokawa, N Hirokawa, N Joseph, NF Endres, NJ Carter, NJ Ganem, OO Rath, P Bieling, Q Chang, R Nitta, R Nunes Bastos, R Uehara, RB Case, RD Vale, Robert A. Cross, S Acar, S Cai, S Cane, S Debonis, S Diez, S Dumont, S Highsmith, S Inoué, S Oh, S Rice, S Rice, S Shastry, SF Bakhoum, SS Rosenfeld, SS Rosenfeld, SW Grill, T Krzysiak, T Maney, T Surrey, TJ Mitchison, TJ Mitchison, TM Kapoor, TT Ogawa, V Fridman, V Magidson, V Mountain, V Varga, VV Bormuth, W Saunders, WW Wang, X Su, X Su, Y Du, Y Kim, Y Kurasawa, Y Oguchi, Y Zhai, YF Dufrene, YM Lee, YY Okada, Z Yang   +184 more
core   +1 more source

Smurf2 as a novel mitotic regulator: From the spindle assembly checkpoint to tumorigenesis

Cell Division, 2009
The execution of the mitotic program with high fidelity is dependent upon precise spatiotemporal regulation of posttranslational protein modifications.
Moore Finola E, Ray Dipankar, Osmundson Evan C, Kiyokawa Hiroaki   +3 more
doaj   +1 more source

Endoplasmic reticulum membranes are continuously required to maintain mitotic spindle size and forces

Life Science Alliance, 2023
Using microinjection approaches in Drosophila embryos, Araújo et al reveal that acute disruption of the ER at centrosome-proximal sites perturbs the architecture of the mitotic spindle, with a direct impact on nuclear positioning.
Margarida Araújo, Alexandra Tavares, Diana V Vieira, Ivo A Telley, Raquel A Oliveira   +4 more
doaj   +1 more source

Anaphase B. [PDF]

, 2016
Anaphase B spindle elongation is characterized by the sliding apart of overlapping antiparallel interpolar (ip) microtubules (MTs) as the two opposite spindle poles separate, pulling along disjoined sister chromatids, thereby contributing to chromosome ...
Brust-Mascher, Ingrid, Civelekoglu-Scholey, Gul, Scholey, Jonathan M   +2 more
core   +2 more sources

USP11 deubiquitinates RAE1 and plays a key role in bipolar spindle formation. [PDF]

PLoS ONE, 2018
Correct segregation of the mitotic chromosomes into daughter cells is a highly regulated process critical to safeguard genome stability. During M phase the spindle assembly checkpoint (SAC) ensures that all kinetochores are correctly attached before its ...
Anna Stockum, Ambrosius P Snijders, Goedele N Maertens   +2 more
doaj   +1 more source

Influence of M-phase chromatin on the anisotropy of microtubule asters [PDF]

, 1996
In many eukaryotic cells going through M-phase, a bipolar spindle is formed by microtubules nucleated from centrosomes. These microtubules, in addition to being "captured" by kinetochores, may be stabilized by chromatin in two different ways: short-range
Dogterom, M., Félix, M. A., Guet, C. C., Leibler, S.   +3 more
core   +2 more sources

Protein Phosphatase 2A (PP2A) Regulates EG5 to Control Mitotic Progression

Scientific Reports, 2017
EG5 (KIF11) is a member of the kinesin-like protein family involved in centrosome separation and bipolar spindle formation. When a cell enters mitosis, CDK1 phosphorylates EG5 at Thr926 and promotes EG5 localization on the mitotic spindle which drives ...
Yang Liu, Zhong Zhang, Hui Liang, Xuyang Zhao, Ling Liang, Guangxi Wang, Jingyi Yang, Yan Jin, Michael A. McNutt, Yuxin Yin   +9 more
doaj   +1 more source