Spindle assembly checkpoint-dependent mitotic delay is required for cell division in absence of centrosomes [PDF]
eLifeThe spindle assembly checkpoint (SAC) temporally regulates mitosis by preventing progression from metaphase to anaphase until all chromosomes are correctly attached to the mitotic spindle.
KC Farrell, Jennifer T Wang, Tim Stearns
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TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching [PDF]
eLife, 2015 The AAA+ family ATPase TRIP13 is a key regulator of meiotic recombination and the spindle assembly checkpoint, acting on signaling proteins of the conserved HORMA domain family.
Qiaozhen Ye +5 more
doaj +4 more sources
Caenorhabditis elegans BUB-3 and SAN-1/MAD3 Spindle Assembly Checkpoint Components Are Required for Genome Stability in Response to Treatment with Ionizing Radiation [PDF]
G3: Genes, Genomes, Genetics, 2017 Relatively little is known about the cross-talk between the spindle assembly checkpoint and the DNA damage response, especially in multicellular organisms.
Simone Bertolini +4 more
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Smurf2 as a novel mitotic regulator: From the spindle assembly checkpoint to tumorigenesis [PDF]
Cell Division, 2009 The execution of the mitotic program with high fidelity is dependent upon precise spatiotemporal regulation of posttranslational protein modifications.
Moore Finola E +3 more
doaj +2 more sources
JAK2-CHK2 signaling safeguards the integrity of the mitotic spindle assembly checkpoint and genome stability [PDF]
Cell Death and Disease, 2022 Checkpoint kinase 2 (CHK2) plays an important role in safeguarding the mitotic progression, specifically the spindle assembly, though the mechanism of regulation remains poorly understood.
Md Al Nayem Chowdhury +5 more
doaj +2 more sources
Human kinetochores are swivel joints that mediate microtubule attachments [PDF]
eLife, 2016 Chromosome segregation is a mechanical process that requires assembly of the mitotic spindle – a dynamic microtubule-based force-generating machine.
Chris A Smith +2 more
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Editorial: Chromosome bi-orientation, tension and the spindle-assembly checkpoint. [PDF]
Front Cell Dev Biol, 2023 Schuyler SC.
europepmc +3 more sources
Centriole assembly and the role of Mps1: defensible or dispensable? [PDF]
Cell Division, 2011 The Mps1 protein kinase is an intriguing and controversial player in centriole assembly. Originally shown to control duplication of the budding yeast spindle pole body, Mps1 is present in eukaryotes from yeast to humans, the nematode C.
Fisk Harold A, Pike Amanda N
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Evaluation of the Spindle Assembly Checkpoint Integrity in Mouse Oocytes. [PDF]
J Vis Exp, 2022 Aboelenain M, Schindler K, Blengini CS.
europepmc +3 more sources
Specialisation of meiotic kinetochores revealed through a synthetic spindle assembly checkpoint strategy. [PDF]
ElifeKoch LB, Ghosh T, Spanos C, Marston AL.
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