Results 11 to 20 of about 36,138 (257)
The spindle assembly checkpoint and speciation [PDF]
PeerJ, 2020 A mechanism is proposed by which speciation may occur without the need to postulate geographical isolation of the diverging populations. Closely related species that occupy overlapping or adjacent ecological niches often have an almost identical genome ...
Robert C. Jackson, Hitesh B. Mistry
doaj +8 more sources
Orchestration of the spindle assembly checkpoint by CDK1‐cyclin B1
FEBS Letters, 2019 In mitosis, the spindle assembly checkpoint (SAC) monitors the formation of microtubule‐kinetochore attachments during capture of chromosomes by the mitotic spindle. Spindle assembly is complete once there are no longer any unattached kinetochores. Here,
Daniel Hayward +2 more
exaly +4 more sources
The spindle assembly checkpoint. [PDF]
Current Biology, 2012 During mitosis and meiosis, the spindle assembly checkpoint acts to maintain genome stability by delaying cell division until accurate chromosome segregation can be guaranteed.
Pablo Lara-Gonzalez +2 more
semanticscholar +4 more sources
Complex Commingling: Nucleoporins and the Spindle Assembly Checkpoint [PDF]
Cells, 2015 The segregation of the chromosomes during mitosis is an important process, in which the replicated DNA content is properly allocated into two daughter cells.
Ikram Mossaid, Birthe Fahrenkrog
doaj +5 more sources
Scientific Reports, 2021 Phosphatidylinositol glycan anchor biosynthesis class N (PIGN) has been linked to the suppression of chromosomal instability. The spindle assembly checkpoint complex is responsible for proper chromosome segregation during mitosis to prevent chromosomal ...
Emmanuel K. Teye +9 more
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Spindle assembly checkpoint activation and silencing at kinetochores
Seminars in Cell & Developmental Biology, 2021 The spindle assembly checkpoint (SAC) is a surveillance mechanism that promotes accurate chromosome segregation in mitosis. The checkpoint senses the attachment state of kinetochores, the proteinaceous structures that assemble onto chromosomes in mitosis
Pablo Lara-Gonzalez, J. Pines, A. Desai
semanticscholar +5 more sources
Reverse engineering of the spindle assembly checkpoint. [PDF]
PLoS ONE, 2009 The Spindle Assembly Checkpoint (SAC) is an intracellular mechanism that ensures proper chromosome segregation. By inhibiting Cdc20, a co-factor of the Anaphase Promoting Complex (APC), the checkpoint arrests the cell cycle until all chromosomes are ...
Andreas Doncic +3 more
doaj +4 more sources
Nature Communications, 2019 During the spindle assembly checkpoint, the activity of the anaphase promoting complex/cyclosome (APC/C) is repressed, yet cyclin A2 evades the checkpoint and is targeted for degradation.
Suyang Zhang +2 more
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TRIP13 Regulates Both the Activation and Inactivation of the Spindle-Assembly Checkpoint
Cell Reports, 2016 Summary: Biochemical studies have indicated that p31comet and TRIP13 are critical for inactivating MAD2. To address unequivocally whether p31comet and TRIP13 are required for mitotic exit at the cellular level, their genes were ablated either ...
Hoi Tang Ma, Randy Yat Choi Poon
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TRIP13 Functions in the Establishment of the Spindle Assembly Checkpoint by Replenishing O-MAD2
Cell Reports, 2018 The spindle assembly checkpoint (SAC) prevents premature segregation of chromosomes during mitosis. This process requires structural remodeling of MAD2 from O-MAD2 to C-MAD2 conformation. After the checkpoint is satisfied, C-MAD2 is reverted to O-MAD2 to
Hoi Tang, Randy Y C Poon
exaly +2 more sources