Results 11 to 20 of about 17,939 (176)
Reverse engineering of the spindle assembly checkpoint. [PDF]
PLoS ONE, 2009 The Spindle Assembly Checkpoint (SAC) is an intracellular mechanism that ensures proper chromosome segregation. By inhibiting Cdc20, a co-factor of the Anaphase Promoting Complex (APC), the checkpoint arrests the cell cycle until all chromosomes are ...
Andreas Doncic +3 more
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Deficient spindle assembly checkpoint in multiple myeloma.
PLoS ONE, 2011 Multiple myeloma (MM) is a hematological disease characterized by an abnormal accumulation of plasma cells in the bone marrow. These cells have frequent cytogenetic abnormalities including translocations of the immunoglobulin heavy chain gene and ...
Elena Díaz-Rodríguez +7 more
doaj +6 more sources
In-silico modeling of the mitotic spindle assembly checkpoint. [PDF]
PLoS ONE, 2008 The Mitotic Spindle Assembly Checkpoint ((M)SAC) is an evolutionary conserved mechanism that ensures the correct segregation of chromosomes by restraining cell cycle progression from entering anaphase until all chromosomes have made proper bipolar ...
Bashar Ibrahim +3 more
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The spindle assembly checkpoint [PDF]
Current Biology, 2008 (Current Biology 18, R391–R395; July 22, 2008)Because of an editorial mistake, Figure 1Figure 1 of this Primer shows pairs of kinetochores (indicated by pairs of yellow dots) during telophase, instead of single kinetochores as indicated in the corrected figure that appears here. The journal regrets this error.Figure 1The SAC as a synchronization device(
Varetti, Gianluca, Musacchio, Andrea
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The Spindle Assembly Checkpoint [PDF]
Current Biology, 2012 During mitosis and meiosis, the spindle assembly checkpoint acts to maintain genome stability by delaying cell division until accurate chromosome segregation can be guaranteed. Accuracy requires that chromosomes become correctly attached to the microtubule spindle apparatus via their kinetochores.
Lara-Gonzalez, Pablo +2 more
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Spindle assembly checkpoint silencing and beyond [PDF]
Cell Cycle, 2016 The Spindle Assembly Checkpoint (SAC) prevents anaphase onset in the absence of kinetochore-microtubule attachment, ensuring that cells with unattached kinetochores do not proceed into anaphase.
Michael, Bokros, Yanchang, Wang
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Attachment and tension in the spindle assembly checkpoint [PDF]
Journal of Cell Science, 2002 Faithful transmission of chromosomes during mitosis is ensured by the spindle assembly checkpoint. This molecular safeguard examines whether prerequisites for chromosome segregation have been satisfied and thereby determines whether to execute or to delay chromosome segregation.
Jun, Zhou, Joyce, Yao, Harish C, Joshi
openaire +2 more sources
Haematologica, 2013 Spindle poison-based therapy is of only limited benefit in acute myeloid leukemia while lymphoblastic leukemia/lymphoma responds well. In this study, we demonstrated that the spindle assembly checkpoint protein BubR1 was down-regulated in the vast ...
Dominik Schnerch +7 more
doaj +1 more source
Cell Division, 2008 During mitosis, correct bipolar chromosome attachment to the mitotic spindle is an essential prerequisite for the equal segregation of chromosomes. The spindle assembly checkpoint can prevent chromosome segregation as long as not all chromosome pairs ...
Maia André F +2 more
doaj +1 more source
The Spindle Assembly Checkpoint Is Required for Hematopoietic Progenitor Cell Engraftment
Stem Cell Reports, 2017 Summary: The spindle assembly checkpoint plays a pivotal role in preventing aneuploidy and transformation. Many studies demonstrate impairment of this checkpoint in cancer cells.
Andreas Brown +9 more
doaj +1 more source