Results 11 to 20 of about 35,751 (255)
The spindle assembly checkpoint and speciation [PDF]
PeerJ, 2020 A mechanism is proposed by which speciation may occur without the need to postulate geographical isolation of the diverging populations. Closely related species that occupy overlapping or adjacent ecological niches often have an almost identical genome ...
Robert C. Jackson, Hitesh B. Mistry
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Reverse engineering of the spindle assembly checkpoint. [PDF]
PLoS ONE, 2009 The Spindle Assembly Checkpoint (SAC) is an intracellular mechanism that ensures proper chromosome segregation. By inhibiting Cdc20, a co-factor of the Anaphase Promoting Complex (APC), the checkpoint arrests the cell cycle until all chromosomes are ...
Andreas Doncic +3 more
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Complex Commingling: Nucleoporins and the Spindle Assembly Checkpoint [PDF]
Cells, 2015 The segregation of the chromosomes during mitosis is an important process, in which the replicated DNA content is properly allocated into two daughter cells.
Ikram Mossaid, Birthe Fahrenkrog
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Deficient spindle assembly checkpoint in multiple myeloma.
PLoS ONE, 2011 Multiple myeloma (MM) is a hematological disease characterized by an abnormal accumulation of plasma cells in the bone marrow. These cells have frequent cytogenetic abnormalities including translocations of the immunoglobulin heavy chain gene and ...
Elena Díaz-Rodríguez +7 more
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Kinetic framework of spindle assembly checkpoint signaling [PDF]
Nature Cell Biology, 2013 Author Posting. © The Author(s), 2013. This is the author's version of the work. It is posted here by permission of Nature Publishing Group for personal use, not for redistribution. The definitive version was published in Nature Cell Biology 15 (2013):
Dick, Amalie E., Gerlich, Daniel W.
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Mimicking Ndc80 phosphorylation triggers spindle assembly checkpoint signalling [PDF]
The EMBO Journal, 2009 The protein kinase Mps1 is, among others, essential for the spindle assembly checkpoint (SAC). We found that Saccharomyces cerevisiae Mps1 interacts physically with the N-terminal domain of Ndc80 (Ndc80(1-257)), a constituent of the Ndc80 kinetochore complex.
Stefan, Kemmler +6 more
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Chronic deregulation of the spindle assembly checkpoint triggers myelosuppression and gastrointestinal atrophy [PDF]
, 2023 Karbon G +11 more
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Spindle assembly checkpoint and its regulators in meiosis [PDF]
Human Reproduction Update, 2011 BACKGROUND Meiosis is a unique form of cell division in which cells divide twice but DNA is duplicated only once. Errors in chromosome segregation during meiosis will result in aneuploidy, followed by loss of the conceptus during pregnancy or birth defects. During mitosis, cells utilize a mechanism called the spindle assembly checkpoint (SAC) to ensure
Shao‐Chen Sun, Nam‐Hyung Kim
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The spindle assembly checkpoint [PDF]
Current Biology, 2008 (Current Biology 18, R391–R395; July 22, 2008)Because of an editorial mistake, Figure 1Figure 1 of this Primer shows pairs of kinetochores (indicated by pairs of yellow dots) during telophase, instead of single kinetochores as indicated in the corrected figure that appears here. The journal regrets this error.Figure 1The SAC as a synchronization device(
Varetti, Gianluca, Musacchio, Andrea
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Scientific Reports, 2021 Phosphatidylinositol glycan anchor biosynthesis class N (PIGN) has been linked to the suppression of chromosomal instability. The spindle assembly checkpoint complex is responsible for proper chromosome segregation during mitosis to prevent chromosomal ...
Emmanuel K. Teye +9 more
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