Results 11 to 20 of about 1,399,702 (223)
The spindle assembly checkpoint [PDF]
Current Biology, 2012 During mitosis and meiosis, the spindle assembly checkpoint acts to maintain genome stability by delaying cell division until accurate chromosome segregation can be guaranteed.
Taylor, Stephen S. +2 more
core +4 more sources
Reverse engineering of the spindle assembly checkpoint. [PDF]
PLoS ONE, 2009 The Spindle Assembly Checkpoint (SAC) is an intracellular mechanism that ensures proper chromosome segregation. By inhibiting Cdc20, a co-factor of the Anaphase Promoting Complex (APC), the checkpoint arrests the cell cycle until all chromosomes are ...
Andreas Doncic +3 more
doaj +4 more sources
Complex Commingling: Nucleoporins and the Spindle Assembly Checkpoint [PDF]
Cells, 2015 The segregation of the chromosomes during mitosis is an important process, in which the replicated DNA content is properly allocated into two daughter cells.
Ikram Mossaid, Birthe Fahrenkrog
doaj +4 more sources
Deficient spindle assembly checkpoint in multiple myeloma.
PLoS ONE, 2011 Multiple myeloma (MM) is a hematological disease characterized by an abnormal accumulation of plasma cells in the bone marrow. These cells have frequent cytogenetic abnormalities including translocations of the immunoglobulin heavy chain gene and ...
Elena Díaz-Rodríguez +7 more
doaj +6 more sources
The Spindle Assembly Checkpoint: Clock or Domino?
, 2011 In each cell division, the newly duplicated chromosomes must be evenly distributed between the sister cells. Errors in this process during meiosis or mitosis are equally fatal: improper segregation of the chromosome 21 during human meiosis leads to Down ...
María de Medina-Redondo +3 more
core +6 more sources
Regulation of mitotic progression by the spindle assembly checkpoint [PDF]
Molecular & Cellular Oncology, 2015 Equal segregation of sister chromatids during mitosis requires that pairs of kinetochores establish proper attachment to microtubules emanating from opposite poles of the mitotic spindle.
Nilsson, Jakob, Lischetti, Tiziana
core +4 more sources
In-silico modeling of the mitotic spindle assembly checkpoint. [PDF]
PLoS ONE, 2008 The Mitotic Spindle Assembly Checkpoint ((M)SAC) is an evolutionary conserved mechanism that ensures the correct segregation of chromosomes by restraining cell cycle progression from entering anaphase until all chromosomes have made proper bipolar ...
Bashar Ibrahim +3 more
doaj +4 more sources
The spindle assembly checkpoint [PDF]
Current Biology, 2008 (Current Biology 18, R391–R395; July 22, 2008)Because of an editorial mistake, Figure 1Figure 1 of this Primer shows pairs of kinetochores (indicated by pairs of yellow dots) during telophase, instead of single kinetochores as indicated in the corrected figure that appears here. The journal regrets this error.Figure 1The SAC as a synchronization device(
Varetti, Gianluca, Musacchio, Andrea
openaire +6 more sources
Spindle assembly checkpoint silencing and beyond [PDF]
Cell Cycle, 2016 The Spindle Assembly Checkpoint (SAC) prevents anaphase onset in the absence of kinetochore-microtubule attachment, ensuring that cells with unattached kinetochores do not proceed into anaphase.
Michael, Bokros, Yanchang, Wang
openaire +2 more sources
Attachment and tension in the spindle assembly checkpoint [PDF]
Journal of Cell Science, 2002 Faithful transmission of chromosomes during mitosis is ensured by the spindle assembly checkpoint. This molecular safeguard examines whether prerequisites for chromosome segregation have been satisfied and thereby determines whether to execute or to delay chromosome segregation.
Jun, Zhou, Joyce, Yao, Harish C, Joshi
openaire +2 more sources