Results 21 to 30 of about 35,751 (255)

The Spindle Assembly Checkpoint [PDF]

Current Biology, 2012
During mitosis and meiosis, the spindle assembly checkpoint acts to maintain genome stability by delaying cell division until accurate chromosome segregation can be guaranteed. Accuracy requires that chromosomes become correctly attached to the microtubule spindle apparatus via their kinetochores.
Lara-Gonzalez, Pablo, Westhorpe, Frederick G., Taylor, Stephen S.   +2 more
openaire   +2 more sources

Ubc1 turnover contributes to the spindle assembly checkpoint in Saccharomyces cerevisiae

G3: Genes, Genomes, Genetics, 2021
The spindle assembly checkpoint protects the integrity of the genome by ensuring that chromosomes are properly attached to the mitotic spindle before they are segregated during anaphase.
Heather E Arsenault, Julie M Ghizzoni, Cassandra M Leech, Anne R Diers, Stephane Gesta, Vivek K Vishnudas, Niven R Narain, Rangaprasad Sarangarajan, Jennifer A Benanti   +8 more
doaj   +1 more source

PICH impacts the spindle assembly checkpoint via its DNA translocase and SUMO-interaction activities. [PDF]

Life Sci Alliance
Lama B, Park H, Saraf A, Hassebroek V, Keifenheim D, Saito-Fujita T, Saitoh N, Aksenova V, Arnaoutov A, Dasso M, Clarke DJ, Azuma Y.   +11 more
europepmc   +3 more sources

Bub1 kinase in the regulation of mitosis

Animal Cells and Systems, 2021
Accurate chromosome segregation is required for cell survival and organismal development. During mitosis, the spindle assembly checkpoint acts as a safeguard to maintain the high fidelity of mitotic chromosome segregation by monitoring the attachment of ...
Taekyung Kim, Anton Gartner
doaj   +1 more source

Yeast Kinesin-5 Motor Protein CIN8 Promotes Accurate Chromosome Segregation

Cells, 2022
Accurate chromosome segregation depends on bipolar chromosome–microtubule attachment and tension generation on chromosomes. Incorrect chromosome attachment results in chromosome missegregation, which contributes to genome instability.
Delaney Sherwin, Abigail Huetteman, Yanchang Wang   +2 more
doaj   +1 more source

Spindle assembly checkpoint silencing and beyond [PDF]

Cell Cycle, 2016
The Spindle Assembly Checkpoint (SAC) prevents anaphase onset in the absence of kinetochore-microtubule attachment, ensuring that cells with unattached kinetochores do not proceed into anaphase.
Michael, Bokros, Yanchang, Wang
openaire   +2 more sources

Dynein Light Intermediate Chain 2 Facilitates the Metaphase to Anaphase Transition by Inactivating the Spindle Assembly Checkpoint. [PDF]

PLoS ONE, 2016
The multi-functional molecular motor cytoplasmic dynein performs diverse essential roles during mitosis. The mechanistic importance of the dynein Light Intermediate Chain homologs, LIC1 and LIC2 is unappreciated, especially in the context of mitosis ...
Sagar P Mahale, Amit Sharma, Sivaram V S Mylavarapu   +2 more
doaj   +1 more source

Spindle assembly checkpoint, aneuploidy and tumorigenesis [PDF]

Cell Cycle, 2009
Faithfully distributing chromosomes into two daughter cells in mitosis is essential for the maintenance of the integrity of the genome genome. The fidelity is achieved through a number of cellular processes among which is the spindle assembly checkpoint (SAC), an elaborate molecular pathway that monitors the attachment of microtubules to kinetochores ...
Min, Li, Pumin, Zhang
openaire   +2 more sources

BubR1 is frequently repressed in acute myeloid leukemia and its re-expression sensitizes cells to antimitotic therapy

Haematologica, 2013
Spindle poison-based therapy is of only limited benefit in acute myeloid leukemia while lymphoblastic leukemia/lymphoma responds well. In this study, we demonstrated that the spindle assembly checkpoint protein BubR1 was down-regulated in the vast ...
Dominik Schnerch, Andrea Schmidts, Marie Follo, Josefina Udi, Julia Felthaus, Dietmar Pfeifer, Monika Engelhardt, Ralph Wäsch   +7 more
doaj   +1 more source

Comment on "A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint" [PDF]

, 2007
Müller et al. (Reports, 27 October 2006, p. 654) showed that inhibition of the γ-tubulin ring complex (γ-TuRC) activates the spindle assembly checkpoint (SAC), which led them to suggest that γ-TuRC proteins play molecular roles in SAC activation. Because
Biggins, Sue, Hardwick, Kevin G, Khodjakov, Alexey, Musacchio, Andrea, Piatti, Simonetta, Rieder, Conly L, Salmon, Edward D, Sawin, Kenneth E, Taylor, Stephen S   +8 more
core   +1 more source