Results 21 to 30 of about 36,138 (257)
Spindle assembly checkpoint-dependent mitotic delay is required for cell division in absence of centrosomes [PDF]
eLifeThe spindle assembly checkpoint (SAC) temporally regulates mitosis by preventing progression from metaphase to anaphase until all chromosomes are correctly attached to the mitotic spindle.
KC Farrell, Jennifer T Wang, Tim Stearns
doaj +2 more sources
Evolutionary Dynamics of the Spindle Assembly Checkpoint in Eukaryotes. [PDF]
Current Biology, 2020 The tremendous diversity in eukaryotic life forms can ultimately be traced back to evolutionary modifications at the level of molecular networks. Deep understanding of these modifications will not only explain cellular diversity, but will also uncover ...
G. Kops, B. Snel, E. Tromer
semanticscholar +4 more sources
Deficient spindle assembly checkpoint in multiple myeloma.
PLoS ONE, 2011 Multiple myeloma (MM) is a hematological disease characterized by an abnormal accumulation of plasma cells in the bone marrow. These cells have frequent cytogenetic abnormalities including translocations of the immunoglobulin heavy chain gene and ...
Elena Díaz-Rodríguez +7 more
doaj +6 more sources
The Spindle Assembly Checkpoint: Clock or Domino?
, 2011 In each cell division, the newly duplicated chromosomes must be evenly distributed between the sister cells. Errors in this process during meiosis or mitosis are equally fatal: improper segregation of the chromosome 21 during human meiosis leads to Down syndrome (Conley, Aneuploidy: etiology and mechanisms, pp 35-89, 1985), whereas in somatic cells ...
de Medina-Redondo, María +1 more
openaire +6 more sources
Regulation of mitotic progression by the spindle assembly checkpoint [PDF]
Molecular & Cellular Oncology, 2015 Equal segregation of sister chromatids during mitosis requires that pairs of kinetochores establish proper attachment to microtubules emanating from opposite poles of the mitotic spindle. The spindle assembly checkpoint (SAC) protects against errors in segregation by delaying sister separation in response to improper kinetochore-microtubule ...
Lischetti, Tiziana, Nilsson, Jakob
openaire +4 more sources
Cell Reports, 2018 Summary: Faithful chromosome segregation during mitosis depends on the spindle assembly checkpoint (SAC), which delays progression through mitosis until every chromosome has stably attached to spindle microtubules via the kinetochore.
Agnieszka Skowyra +3 more
doaj +2 more sources
In-silico modeling of the mitotic spindle assembly checkpoint. [PDF]
PLoS ONE, 2008 The Mitotic Spindle Assembly Checkpoint ((M)SAC) is an evolutionary conserved mechanism that ensures the correct segregation of chromosomes by restraining cell cycle progression from entering anaphase until all chromosomes have made proper bipolar ...
Bashar Ibrahim +3 more
doaj +4 more sources
Determinants of robustness in spindle assembly checkpoint signalling
Nature Cell Biology, 2013 The spindle assembly checkpoint is a conserved signalling pathway that protects genome integrity. Given its central importance, this checkpoint should withstand stochastic fluctuations and environmental perturbations, but the extent of and mechanisms underlying its robustness remain unknown.
Stephanie Heinrich +9 more
openaire +4 more sources
The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics.
Current Biology, 2015 The spindle assembly checkpoint is a safeguard mechanism that coordinates cell-cycle progression during mitosis with the state of chromosome attachment to the mitotic spindle.
A. Musacchio
semanticscholar +2 more sources
The Spindle Assembly Checkpoint in Arabidopsis Is Rapidly Shut Off during Severe Stress
Developmental Cell, 2017 Shinichiro Komaki, Arp Schnittger
exaly +2 more sources