Results 31 to 40 of about 36,138 (257)

The spindle assembly checkpoint [PDF]

Current Biology, 2008
(Current Biology 18, R391–R395; July 22, 2008)Because of an editorial mistake, Figure 1Figure 1 of this Primer shows pairs of kinetochores (indicated by pairs of yellow dots) during telophase, instead of single kinetochores as indicated in the corrected figure that appears here. The journal regrets this error.Figure 1The SAC as a synchronization device(
Varetti, Gianluca, Musacchio, Andrea
openaire   +6 more sources

Micronuclei from misaligned chromosomes that satisfy the spindle assembly checkpoint in cancer cells

Current Biology, 2022
Summary Chromosome alignment to the spindle equator is a hallmark of mitosis thought to promote chromosome segregation fidelity in metazoans. Yet chromosome alignment is only indirectly supervised by the spindle assembly checkpoint (SAC) as a byproduct ...
A. M. Gomes, B. Orr, Marco Novais-Cruz, Filipe De Sousa, Joana Macário-Monteiro, C. Lemos, C. Ferrás, H. Maiato   +7 more
semanticscholar   +1 more source

Role of spindle assembly checkpoint proteins in gametogenesis and embryogenesis [PDF]

Frontiers in Cell and Developmental Biology
Brian J North
exaly   +2 more sources

Knl1 participates in spindle assembly checkpoint signaling in maize

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance The spindle assembly checkpoint (SAC) signaling controls the attachments of kinetochores to spindle microtubules rigorously. However, how SAC proteins connect to the kinetochores is largely unknown in plants.
H. Su, Yang Liu, Chunhui Wang, Yalin Liu, Chao Feng, Yishuang Sun, Jing Yuan, J. Birchler, F. Han   +8 more
semanticscholar   +1 more source

Ubc1 turnover contributes to the spindle assembly checkpoint in Saccharomyces cerevisiae

G3: Genes, Genomes, Genetics, 2021
The spindle assembly checkpoint protects the integrity of the genome by ensuring that chromosomes are properly attached to the mitotic spindle before they are segregated during anaphase.
Heather E Arsenault, Julie M Ghizzoni, Cassandra M Leech, Anne R Diers, Stephane Gesta, Vivek K Vishnudas, Niven R Narain, Rangaprasad Sarangarajan, Jennifer A Benanti   +8 more
doaj   +1 more source

Aurora B phosphorylates Bub1 to promote spindle assembly checkpoint signaling

bioRxiv, 2021
Accurate chromosome segregation during cell division requires amphitelic chromosome attachment to the spindle apparatus. It is ensured by the combined activity of the Spindle Assembly Checkpoint (SAC) [1], a signaling mechanism that delays anaphase onset
Babhrubahan Roy, Simon J. Y. Han, A. Fontan, Soubhagyalakshmi Jema, Ajit P. Joglekar   +4 more
semanticscholar   +1 more source

Bub1 kinase in the regulation of mitosis

Animal Cells and Systems, 2021
Accurate chromosome segregation is required for cell survival and organismal development. During mitosis, the spindle assembly checkpoint acts as a safeguard to maintain the high fidelity of mitotic chromosome segregation by monitoring the attachment of ...
Taekyung Kim, Anton Gartner
doaj   +1 more source

An Attachment-Independent Biochemical Timer of the Spindle Assembly Checkpoint

Molecular Cell, 2017
Junbin Qian, Maria Adelaida Garcia-Gimeno, Monique Beullens   +2 more
exaly   +2 more sources

Yeast Kinesin-5 Motor Protein CIN8 Promotes Accurate Chromosome Segregation

Cells, 2022
Accurate chromosome segregation depends on bipolar chromosome–microtubule attachment and tension generation on chromosomes. Incorrect chromosome attachment results in chromosome missegregation, which contributes to genome instability.
Delaney Sherwin, Abigail Huetteman, Yanchang Wang   +2 more
doaj   +1 more source

Spindle assembly checkpoint silencing and beyond [PDF]

Cell Cycle, 2016
The Spindle Assembly Checkpoint (SAC) prevents anaphase onset in the absence of kinetochore-microtubule attachment, ensuring that cells with unattached kinetochores do not proceed into anaphase.
Michael, Bokros, Yanchang, Wang
openaire   +2 more sources