Some assembly required: Redefining the mitotic checkpoint
Molecular & Cellular Oncology, 2017 The spindle assembly checkpoint (also known as the spindle or mitotic checkpoint) is a surveillance system that ensures fidelity of chromosome segregation.
John C. Meadows, Jonathan B. A. Millar
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Latrunculin A delays anaphase onset in fission yeast by disrupting an ase1-independent pathway controlling mitotic spindle stability [PDF]
, 2008 It has been proposed previously that latrunculin A, an inhibitor of actin polymerization, delays the onset of anaphase by causing spindle misorientation in fission yeast.
Meadows, John C., Millar, Jonathan B. A.
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Noise resistance in the spindle assembly checkpoint [PDF]
Molecular Systems Biology, 2006 Genetically identical cells vary in the amount of expressed proteins even when growing under the same conditions. It is not yet clear how cellular information processing copes with such stochastic fluctuations in protein levels. Here we examine the capacity of the spindle assembly checkpoint to buffer temporal fluctuations in the expression of Cdc20, a
Doncic, Andreas +2 more
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Mad3 KEN boxes mediate both Cdc20 and Mad3 turnover, and are critical for the spindle checkpoint [PDF]
, 2007 Mitotic progression is controlled by proteolytic destruction of securin and cyclin. The mitotic E3 ubiquitin ligase, known as the anaphase promoting complex or cyclosome (APC/C), in partnership with its activators Cdc20p and Cdh1p, targets these proteins
Emma M J King +8 more
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MAP kinase meets mitosis: A role for Raf Kinase Inhibitory Protein in spindle checkpoint regulation
Cell Division, 2007 Raf Kinase Inhibitory Protein (RKIP) is an evolutionarily conserved protein that functions as a modulator of signaling by the MAP kinase cascade.
Rosner Marsha
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On the regulation of chromosome segregation in human cells : implications of Bub1 Kinase inhibition during cell division [PDF]
, 2015 The maintenance of correct chromosome number (euploidy) during cell division is essential for health. Loss of euploidy is observed in most cancers and is linked to tumorigenesis.
Baron, Anna
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Cell Death and Disease, 2022 Checkpoint kinase 2 (CHK2) plays an important role in safeguarding the mitotic progression, specifically the spindle assembly, though the mechanism of regulation remains poorly understood.
Md Al Nayem Chowdhury +5 more
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Characterization of mitotic checkpoint complexes [PDF]
, 2011 In eukaryotes, chromosome segregation critically depends on the establishment of productive contacts between kinetochores (KTs), specialized chromosomal structures, and the spindle microtubules (MTs).
Fava, Luca
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Requirement for proteolysis in spindle assembly checkpoint silencing [PDF]
Cell Cycle, 2010 Anaphase initiation requires ubiquitin-dependent proteolysis of crucial substrates through activation of the ubiquitin ligase Anaphase promoting Complex/Cyclosome (ApC/C) in association with its coactivator Cdc20. To prevent chromosome segregation errors, effector proteins of a safeguard mechanism called spindle assembly checkpoint (SAC), Mad2 and ...
Visconti R. +2 more
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TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching
eLife, 2015 The AAA+ family ATPase TRIP13 is a key regulator of meiotic recombination and the spindle assembly checkpoint, acting on signaling proteins of the conserved HORMA domain family.
Qiaozhen Ye +5 more
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