Results 41 to 50 of about 36,138 (257)

Dynein Light Intermediate Chain 2 Facilitates the Metaphase to Anaphase Transition by Inactivating the Spindle Assembly Checkpoint. [PDF]

PLoS ONE, 2016
The multi-functional molecular motor cytoplasmic dynein performs diverse essential roles during mitosis. The mechanistic importance of the dynein Light Intermediate Chain homologs, LIC1 and LIC2 is unappreciated, especially in the context of mitosis ...
Sagar P Mahale, Amit Sharma, Sivaram V S Mylavarapu   +2 more
doaj   +1 more source

A YAP/FOXM1 axis mediates EMT-associated EGFR inhibitor resistance and increased expression of spindle assembly checkpoint components

Science Translational Medicine, 2020
YAP and FOXM1 are mediators of EGFR inhibitor resistance, and spindle proteins are therapeutic targets for this multidrug-resistant phenotype. Path of least resistance Drugs that inhibit the epidermal growth factor (EGFR) are used in a number of cancer ...
M. Nilsson, Huiying Sun, J. Robichaux, Matthias Pfeifer, U. McDermott, Jon Travers, L. Diao, Y. Xi, P. Tong, Li Shen, Mia Hofstad, Masanori Kawakami, X. Le, Xi Liu, Youhong Fan, A. Poteete, Limei Hu, M. Negrão, H. Tran, E. Dmitrovsky, D. Peng, D. Gibbons, Jing Wang, J. Heymach   +23 more
semanticscholar   +1 more source

Attachment and tension in the spindle assembly checkpoint [PDF]

Journal of Cell Science, 2002
Faithful transmission of chromosomes during mitosis is ensured by the spindle assembly checkpoint. This molecular safeguard examines whether prerequisites for chromosome segregation have been satisfied and thereby determines whether to execute or to delay chromosome segregation.
Jun, Zhou, Joyce, Yao, Harish C, Joshi
openaire   +2 more sources

Bub3p facilitates spindle checkpoint silencing in fission yeast [PDF]

, 2009
Although critical for spindle checkpoint signaling, the role kinetochores play in anaphase promoting complex (APC) inhibition remains unclear. Here we show that spindle checkpoint proteins are severely depleted from unattached kinetochores in fission ...
Hardwick, Kevin G., Millar, Jonathan B.A., van der Sar, Sjaak J. A., van der Sar, Sjaak J A, van Der Sar, Sjaak J.A., Millar, Jonathan B. A., Vanoosthuyse, Vincent, Millar, Jonathan B A, Meadows, John C, Vanoosthuyse, V., Hardwick, Kevin, Meadows, John, Meadows, John C., Hardwick, Kevin G   +13 more
core   +1 more source

BubR1 is frequently repressed in acute myeloid leukemia and its re-expression sensitizes cells to antimitotic therapy

Haematologica, 2013
Spindle poison-based therapy is of only limited benefit in acute myeloid leukemia while lymphoblastic leukemia/lymphoma responds well. In this study, we demonstrated that the spindle assembly checkpoint protein BubR1 was down-regulated in the vast ...
Dominik Schnerch, Andrea Schmidts, Marie Follo, Josefina Udi, Julia Felthaus, Dietmar Pfeifer, Monika Engelhardt, Ralph Wäsch   +7 more
doaj   +1 more source

Mitotic slippage is determined by p31comet and the weakening of the spindle-assembly checkpoint

Oncogene, 2020
Mitotic slippage involves cells exiting mitosis without proper chromosome segregation. Although degradation of cyclin B1 during prolonged mitotic arrest is believed to trigger mitotic slippage, its upstream regulation remains obscure.
T. Lok, Yang Wang, Wendy Kaichun Xu, S. Xie, H. Ma, R. Poon   +5 more
semanticscholar   +1 more source

Checkpoint proteins come under scrutiny [PDF]

, 2013
Details are emerging of the interactions between the kinetochore and various spindle checkpoint proteins that ensure that sister chromatids are equally divided between daughter cells during cell ...
Jonathan BA Millar, Mora-Santos, Maria, Millar, Jonathan B. A., Maria Mora-Santos   +3 more
core   +1 more source

The chromosomal passenger complex and the spindle assembly checkpoint: kinetochore-microtubule error correction and beyond

Cell Division, 2008
During mitosis, correct bipolar chromosome attachment to the mitotic spindle is an essential prerequisite for the equal segregation of chromosomes. The spindle assembly checkpoint can prevent chromosome segregation as long as not all chromosome pairs ...
Maia André F, Vader Gerben, Lens Susanne MA   +2 more
doaj   +1 more source

The A78V mutation in the Mad3-like domain of Schizosaccharomyces pombe Bub1p perturbs nuclear accumulation and kinetochore targeting of Bub1p, Bub3p, and Mad3p and spindle assembly checkpoint function [PDF]

, 2005
During mitosis, the spindle assembly checkpoint (SAC) responds to faulty attachments between kinetochores and the mitotic spindle by imposing a metaphase arrest until the defect is corrected, thereby preventing chromosome missegregation. A genetic screen
Vanoosthuyse, V., Hardwick, Kevin, Kadura, Sheila, Sazer, Shelley, He, Xiangwei, Vanoosthuyse, Vincent, Hardwick, Kevin G   +6 more
core   +1 more source

The Spindle Assembly Checkpoint Is Required for Hematopoietic Progenitor Cell Engraftment

Stem Cell Reports, 2017
Summary: The spindle assembly checkpoint plays a pivotal role in preventing aneuploidy and transformation. Many studies demonstrate impairment of this checkpoint in cancer cells.
Andreas Brown, Johannes Pospiech, Karina Eiwen, Darren J. Baker, Bettina Moehrle, Vadim Sakk, Kalpana Nattamai, Mona Vogel, Ani Grigoryan, Hartmut Geiger   +9 more
doaj   +1 more source