Results 41 to 50 of about 35,751 (255)

Some assembly required: Redefining the mitotic checkpoint

Molecular & Cellular Oncology, 2017
The spindle assembly checkpoint (also known as the spindle or mitotic checkpoint) is a surveillance system that ensures fidelity of chromosome segregation.
John C. Meadows, Jonathan B. A. Millar
doaj   +1 more source

HIPK2 and extrachromosomal histone H2B are separately recruited by Aurora-B for cytokinesis [PDF]

, 2018
Cytokinesis, the final phase of cell division, is necessary to form two distinct daughter cells with correct distribution of genomic and cytoplasmic materials.
A Konishi, A Verdina, AC Borisa, AT Lau, B Mierzwa, C Ditchfield, C Lazzari, C Mollinari, C Norden, C Rinaldo, C Rinaldo, C Rinaldo, C Rinaldo, Cinzia Rinaldo, CK Hu, D Valente, Davide Valente, E Gresko, F Siepi, G D’Orazi, G D’Orazi, G Normand, GE Atilla-Gokcumen, H Goto, HC Huang, I Vitale, JA Blaquiere, JM Cummins, JP Fededa, JR Bischoff, K Kobiyama, L Vega De la, Laura Monteonofrio, M Agromayor, M Carmena, M Glotzer, M Kollareddy, Manuela Ferrara, Marco Crescenzi, ME Douglas, ME Douglas, O Afonso, P Carpinelli, PP D’Avino, R Kuriyama, R Nunes Bastos, Roberta Miscione, S Francia, S Hauf, S Matt, Serena Camerini, Silvia Soddu, SM Lens, TD Pollard, TG Hofmann, TG Hofmann, V Bavetsias, VV Saul, VV Saul, WM Zhao, XL Li, Y Feng, Y Kuwano, Y Terada, YH Kim, Z Storchova   +65 more
core   +1 more source

Kinetochore stretching inactivates the spindle assembly checkpoint [PDF]

Journal of Cell Biology, 2009
The spindle assembly checkpoint (SAC) monitors the attachment of microtubules to the kinetochore and inhibits anaphase when microtubule binding is incomplete. The SAC might also respond to tension; however, how cells can sense tension and whether its detection is important to satisfy the SAC remain controversial.
Uchida, Kazuhiko S.K., Takagaki, Kentaro, Kumada, Kazuki, Hirayama, Youko, Noda, Tetsuo, Hirota, Toru   +5 more
openaire   +2 more sources

TRIP13 Regulates Both the Activation and Inactivation of the Spindle-Assembly Checkpoint

Cell Reports, 2016
Summary: Biochemical studies have indicated that p31comet and TRIP13 are critical for inactivating MAD2. To address unequivocally whether p31comet and TRIP13 are required for mitotic exit at the cellular level, their genes were ablated either ...
Hoi Tang Ma, Randy Yat Choi Poon
doaj   +1 more source

Chromosome segregation in plant meiosis [PDF]

, 2014
Faithful chromosome segregation in meiosis is essential for ploidy stability over sexual life cycles. In plants, defective chromosome segregation caused by gene mutations or other factors leads to the formation of unbalanced or unreduced gametes creating
De Storme, Nico, Geelen, Danny, Pawlowski, Wojtek, Tiang, Choon Lin, Zamariola, Linda   +4 more
core   +2 more sources

Spindle assembly checkpoint: the third decade [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2011
The spindle assembly checkpoint controls cell cycle progression during mitosis, synchronizing it with the attachment of chromosomes to spindle microtubules. After the discovery of themitotic arrest deficient(MAD) andbudding uninhibited by benzymidazole(BUB) genes as crucial checkpoint components in 1991, the second decade of checkpoint studies (2001 ...
openaire   +3 more sources

Noise resistance in the spindle assembly checkpoint [PDF]

Molecular Systems Biology, 2006
Genetically identical cells vary in the amount of expressed proteins even when growing under the same conditions. It is not yet clear how cellular information processing copes with such stochastic fluctuations in protein levels. Here we examine the capacity of the spindle assembly checkpoint to buffer temporal fluctuations in the expression of Cdc20, a
Doncic, Andreas, Ben-Jacob, Eshel, Barkai, Naama   +2 more
openaire   +2 more sources

MAP kinase meets mitosis: A role for Raf Kinase Inhibitory Protein in spindle checkpoint regulation

Cell Division, 2007
Raf Kinase Inhibitory Protein (RKIP) is an evolutionarily conserved protein that functions as a modulator of signaling by the MAP kinase cascade.
Rosner Marsha
doaj   +1 more source

Co-silencing of human Bub3 and dynein highlights an antagonistic relationship in regulating kinetochore-microtubule attachments [PDF]

, 2015
We previously reported that the spindle assembly checkpoint protein Bub3 is involved in regulating kinetochore-microtubule (KT-MT) attachments. Also, Bub3 was reported to interact with the microtubule motor protein dynein.
Barisic, Efimov, Gassmann, Gassmann, Gassmann, Hassan Bousbaa, Kops, Lo, Logarinho, Logarinho, Maia, Maresca, Musacchio, Patrícia M.A. Silva, Pfarr, Reis, Rieder, Sharp, Silva, Silva, Stehman, Steuer, Uchida, Vaisberg, Varma, Waters, Yang, Álvaro A. Tavares   +27 more
core   +1 more source

Requirement for proteolysis in spindle assembly checkpoint silencing [PDF]

Cell Cycle, 2010
Anaphase initiation requires ubiquitin-dependent proteolysis of crucial substrates through activation of the ubiquitin ligase Anaphase promoting Complex/Cyclosome (ApC/C) in association with its coactivator Cdc20. To prevent chromosome segregation errors, effector proteins of a safeguard mechanism called spindle assembly checkpoint (SAC), Mad2 and ...
Visconti R., PALAZZO, LUCA, GRIECO, DOMENICO   +2 more
openaire   +4 more sources