Results 61 to 70 of about 17,939 (176)
No stretch for spindle assembly checkpoint [PDF]
The Journal of Cell Biology, 2008 ![][1] Kinetochores (red) attach to the spindle (green), whereas chromatin (blue) is largely excluded. Dividing cells aren't quite as obsessed with quality control as previously thought, according to results from [O'Connell and colleagues][2].
openaire +1 more source
CD93—An emerging vascular target in cancer therapy
British Journal of Pharmacology, EarlyView.Abstract CD93 is a single‐pass transmembrane glycoprotein that belongs to the C‐type lectin domain group XIV family of proteins. Although it is known to be expressed in other cell types, namely, in some subsets of immune cells, CD93 is primarily expressed on endothelial cells, where it acts as a crucial regulator of angiogenesis.
Beatriz de Alves Pereira +3 more
wiley +1 more source
Targeting Cell Cycle Vulnerabilities in Cancers: Emerging Strategies for Therapeutic Development
Cancer Science, EarlyView.Dysregulated cell cycle control often involves alternative compensatory pathways in cancers to maintain its robustness but provide unique targetable vulnerabilities. We overview recent insights on cancer‐specific vulnerabilities across the cell cycle and discuss how these can be used to develop new therapeutic strategies.
Nana Kamakura +3 more
wiley +1 more source
The equatorial position of the metaphase plate ensures symmetric cell divisions
eLife, 2015 Chromosome alignment in the middle of the bipolar spindle is a hallmark of metazoan cell divisions. When we offset the metaphase plate position by creating an asymmetric centriole distribution on each pole, we find that metaphase plates relocate to the ...
Chia Huei Tan +6 more
doaj +1 more source
USP49 deubiquitinase regulates the mitotic spindle checkpoint and prevents aneuploidy
Cell Death and Disease, 2023 The spindle assembly checkpoint (SAC) is an essential mechanism that ensures the accurate chromosome segregation during mitosis, thus preventing genomic instability.
Diana Campos-Iglesias +7 more
doaj +1 more source
Oral Diseases, EarlyView.ABSTRACT Objectives To identify molecular mechanisms distinguishing the erosive subtype of oral lichen planus (EOLP) from the non‐erosive subtype (NEOLP) through transcriptomic analysis. Methods We analysed bulk RNA‐seq data from 30 buccal mucosa samples (13 EOLP, 17 NEOLP) using differential expression, Gene Set Enrichment Analysis (GSEA ...
Kisung Sheen +5 more
wiley +1 more source
Insights into mitotic checkpoint by integrating CRISPR and RNAi
Molecular & Cellular Oncology, 2019 Our recent study of the mitotic checkpoint protein BUB1 (budding uninhibited by benzimidazoles 1) revealed several apparent BUB1 knock-out cell lines expressing low levels of BUB1 protein sufficient to support spindle assembly checkpoint activity.
Gang Zhang
doaj +1 more source
Tracing the Pathway of Spindle Assembly Checkpoint Signaling [PDF]
Developmental Cell, 2001 Most current models of spindle assembly checkpoint signaling involve inhibition of the Cdc20-APC by Mad2 protein. Interestingly, a paper from Hongtao Yu and colleagues in this issue of Developmental Cell suggests that the Cdc20/APC can also be inhibited in a Mad2-independent manner by a complex of proteins that includes BubR1.
Gillett, Emily S., Sorger, Peter K.
openaire +2 more sources
The Secret (Mitotic) Life of Clathrin
Traffic, Volume 27, Issue 3, September 2026.A perspective on the function of clathrin at the mitotic spindle during cell division. ABSTRACT The discovery of clathrin was a foundational event in membrane traffic research. Its identification as the major protein component of the coat that surrounds endocytic vesicles kickstarted the biochemical and molecular characterization of endocytosis. During
Stephen J. Royle
wiley +1 more source
Cell Reports, 2018 Summary: Faithful chromosome segregation during mitosis depends on the spindle assembly checkpoint (SAC), which delays progression through mitosis until every chromosome has stably attached to spindle microtubules via the kinetochore.
Agnieszka Skowyra +3 more
doaj +1 more source