Results 81 to 90 of about 35,751 (255)
Bub3-Bub1 binding to Spc7/KNL1 toggles the spindle checkpoint switch by licensing the interaction of Bub1 with Mad1-Mad2 [PDF]
, 2016 The spindle assembly checkpoint (SAC) ensures that sister chromatids do not separate until all chromosomes are attached to spindle microtubules and bi-oriented. Spindle checkpoint proteins, including Mad1, Mad2, Mad3 (BubR1), Bub1, Bub3, and Mph1 (Mps1),
Hervas-Aguilar, Maria-America +5 more
core +1 more source
Hypoxia Induces a Mitotic Survival Advantage After Radiotherapy in Head and Neck Cancer Cells
International Journal of Cancer, EarlyView.Hypoxic tumor environments significantly limit radiotherapy effectiveness against cancer, particularly in head and neck squamous cell carcinoma (HNSCC). Here, the authors tracked hypoxic and post‐hypoxic cells using a hypoxia‐fate mapping system in human papillomavirus (HPV)‐positive and HPV‐negative HNSCC models.
Marilyn Wegge +3 more
wiley +1 more source
Tracing the Pathway of Spindle Assembly Checkpoint Signaling [PDF]
Developmental Cell, 2001 Most current models of spindle assembly checkpoint signaling involve inhibition of the Cdc20-APC by Mad2 protein. Interestingly, a paper from Hongtao Yu and colleagues in this issue of Developmental Cell suggests that the Cdc20/APC can also be inhibited in a Mad2-independent manner by a complex of proteins that includes BubR1.
Gillett, Emily S., Sorger, Peter K.
openaire +2 more sources
Interactions between N-terminal Modules in MPS1 Enable Spindle Checkpoint Silencing
Cell Reports, 2019 Summary: Faithful chromosome segregation relies on the ability of the spindle assembly checkpoint (SAC) to delay anaphase onset until chromosomes are attached to the mitotic spindle via their kinetochores.
Spyridon T. Pachis +4 more
doaj +1 more source
How to halve ploidy : lessons from budding yeast meiosis [PDF]
, 2012 Maintenance of ploidy in sexually reproducing organisms requires a specialized form of cell division called meiosis that generates genetically diverse haploid gametes from diploid germ cells.
Arumugam, Prakash +2 more
core +1 more source
Cell Proliferation, EarlyView.The endoplasmic reticulum membrane protein complex (EMC) is an evolutionarily conserved, multi‐subunit transmembrane protein complex crucial to membrane protein biogenesis and cellular protein quality control. This review systematically examines the structure, functions and disease‐associated regulatory mechanisms of EMC across multiple organ systems ...
Yan Qiao +6 more
wiley +1 more source
Chromosome Segregation Is Biased by Kinetochore Size [PDF]
, 2018 Chromosome missegregation during mitosis or meiosis is a hallmark of cancer and the main cause of prenatal death in humans. The gain or loss of specific chromosomes is thought to be random, with cell viability being essentially determined by selection ...
Aguiar, P +8 more
core +2 more sources
Photochemistry and Photobiology, EarlyView.Exposure to solar ultraviolet radiation is the main etiologic driver of nonmelanoma skin cancers (NMSCs), including basal cell (BCC) and cutaneous squamous cell carcinomas (cSCC), which are the most prevalent types of cancers in the US. In this study, we demonstrate that the serine/threonine kinase Polo‐like kinase 4 (PLK4) is overexpressed in NMSCs ...
Mary A. Ndiaye +5 more
wiley +1 more source
No stretch for spindle assembly checkpoint [PDF]
The Journal of Cell Biology, 2008 ![][1] Kinetochores (red) attach to the spindle (green), whereas chromatin (blue) is largely excluded. Dividing cells aren't quite as obsessed with quality control as previously thought, according to results from [O'Connell and colleagues][2].
openaire +1 more source
Axin-1 Regulates Meiotic Spindle Organization in Mouse Oocytes. [PDF]
PLoS ONE, 2016 Axin-1, a negative regulator of Wnt signaling, is a versatile scaffold protein involved in centrosome separation and spindle assembly in mitosis, but its function in mammalian oogenesis remains unknown.
Xiao-Qin He +12 more
doaj +1 more source