Results 81 to 90 of about 1,399,702 (223)

Engineered Peptide Self‐Assembled Nanofibers for Enhanced STING Activation: A Promising Nanodelivery Platform for Immunotherapy of Pediatric Solid Tumors

Advanced Science, EarlyView.
An engineered peptide self‐assembled nanofiber platform, designed to replicate STING–cGAMP binding motifs, facilitates pH‐responsive cytosolic delivery of cGAMP, enhances the endoplasmic reticulum with high efficiency, and robustly activates the STING pathway.
Yubin He, Xiao Lu, Chang qing Yang, Ran Zhang, Bo Wan, Xin Ni, Dong Mei   +6 more
wiley   +1 more source

Bub1 autophosphorylation feeds back to regulate kinetochore docking and promote localized substrate phosphorylation [PDF]

, 2015
During mitosis, Bub1 kinase phosphorylates histone H2A-T120 to promote centromere sister chromatid cohesion through recruitment of shugoshin (Sgo) proteins. The regulation and dynamics of H2A-T120 phosphorylation are poorly understood. Using quantitative
Lajeunesse, Audrey, Asghar, Adeel, Combes, Guillaume, Thebault, Philippe, Dulla, Kalyan, Elowe, Sabine, Nigg, Erich A.   +6 more
core   +1 more source

Spindle assembly checkpoint and its regulators in meiosis [PDF]

Human Reproduction Update, 2011
BACKGROUND Meiosis is a unique form of cell division in which cells divide twice but DNA is duplicated only once. Errors in chromosome segregation during meiosis will result in aneuploidy, followed by loss of the conceptus during pregnancy or birth defects. During mitosis, cells utilize a mechanism called the spindle assembly checkpoint (SAC) to ensure
Shao-Chen, Sun, Nam-Hyung, Kim
openaire   +2 more sources

USP4‐Dependent CHAF1B Stabilization Regulates Distinct SETDB1 Ubiquitin States Linked to AKT T308 Signaling and Lipogenic Remodeling in HCC

Advanced Science, EarlyView.
USP4 stabilizes CHAF1B by limiting K48‐linked ubiquitination. Stabilized CHAF1B supports UHRF1‐associated K63‐linked SETDB1 ubiquitination and cytoplasmic redistribution, whereas CHAF1B loss favors VHL‐dependent K11‐associated degradative ubiquitination and proteasomal loss of SETDB1.
Saiyan Bian, Yun Tong, Wenkai Ni, Zhangzhi Tang, Weiting Chen, Kexin Ma, Lihan Jiang, Jiayu Shao, Xuyang He, Wenjie Zheng   +9 more
wiley   +1 more source

TRAIP is a regulator of the spindle assembly checkpoint.

Journal of cell science, 2014
Accurate chromosome segregation during mitosis is temporally and spatially coordinated by fidelity-monitoring checkpoint systems. Deficiencies in these checkpoint systems can lead to chromosome segregation errors and aneuploidy, and promote tumorigenesis.
Chapard, Christophe, Meraldi, Patrick, Gleich, Tobias, Bachmann, Daniel, Hohl, Daniel, Huber, Marcel   +5 more
openaire   +4 more sources

Tracing the Pathway of Spindle Assembly Checkpoint Signaling [PDF]

Developmental Cell, 2001
Most current models of spindle assembly checkpoint signaling involve inhibition of the Cdc20-APC by Mad2 protein. Interestingly, a paper from Hongtao Yu and colleagues in this issue of Developmental Cell suggests that the Cdc20/APC can also be inhibited in a Mad2-independent manner by a complex of proteins that includes BubR1.
Gillett, Emily S., Sorger, Peter K.
openaire   +2 more sources

Axin-1 Regulates Meiotic Spindle Organization in Mouse Oocytes. [PDF]

PLoS ONE, 2016
Axin-1, a negative regulator of Wnt signaling, is a versatile scaffold protein involved in centrosome separation and spindle assembly in mitosis, but its function in mammalian oogenesis remains unknown.
Xiao-Qin He, Yue-Qiang Song, Rui Liu, Yu Liu, Fei Zhang, Zhen Zhang, Yu-Ting Shen, Lin Xu, Ming-Huang Chen, Ya-Long Wang, Bai-Hui Xu, Xiang-Jun Yang, Hai-Long Wang   +12 more
doaj   +1 more source

Engineered 3D Fibronectin‐Based Environments Modulate the Pathogenic Profile of Arthritic Synovial Fibroblasts

Advanced NanoBiomed Research, EarlyView.
Fibroblast behavior is shaped by the surrounding microenvironment, yet conventional culture systems often fail to capture disease‐relevant phenotypes. Here, platform‐dependent responses of healthy and arthritic synovial fibroblasts are examined across 2D and 3D culture systems. Distinct inflammatory and proliferative signatures emerge, highlighting how
Aneesah Khan, Piaopiao Pan, Yanling Lan, Çağlar Çi̇l, Julia Isakova, Yilin Wang, Theodora Rogkoti, Thanutchaporn Sartyoungkul, James F. C. Windmill, Jonathan William, Manuel Salmeron‐Sanchez, Margaret H. Harnett, Oana Dobre, Miguel A. Pineda   +13 more
wiley   +1 more source

The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability [PDF]

, 2009
Myc-induced SUN domain–containing protein (Misu or NSun2) is a nucleolar RNA methyltransferase important for c-Myc–induced proliferation in skin, but the mechanisms by which Misu contributes to cell cycle progression are unknown.
Michaela Frye, Benavente, Sandra Blanco, Elisabete Nascimento, Kurowski, Agata, Nascimento, Elisabete, Hussain, Shobbir, Ilaria Dragoni, Dragoni, Ilaria, Gillich, Astrid, Shobbir Hussain, Sandra Blanco Benavente, Astrid Gillich, Frye, Michaela, Peter Humphreys, Humphreys, Peter, Agata Kurowski   +15 more
core   +1 more source

The equatorial position of the metaphase plate ensures symmetric cell divisions

eLife, 2015
Chromosome alignment in the middle of the bipolar spindle is a hallmark of metazoan cell divisions. When we offset the metaphase plate position by creating an asymmetric centriole distribution on each pole, we find that metaphase plates relocate to the ...
Chia Huei Tan, Ivana Gasic, Sabina P Huber-Reggi, Damian Dudka, Marin Barisic, Helder Maiato, Patrick Meraldi   +6 more
doaj   +1 more source