Results 81 to 90 of about 17,939 (176)

Smurf2 as a novel mitotic regulator: From the spindle assembly checkpoint to tumorigenesis

Cell Division, 2009
The execution of the mitotic program with high fidelity is dependent upon precise spatiotemporal regulation of posttranslational protein modifications.
Moore Finola E, Ray Dipankar, Osmundson Evan C, Kiyokawa Hiroaki   +3 more
doaj   +1 more source

Centriole assembly and the role of Mps1: defensible or dispensable?

Cell Division, 2011
The Mps1 protein kinase is an intriguing and controversial player in centriole assembly. Originally shown to control duplication of the budding yeast spindle pole body, Mps1 is present in eukaryotes from yeast to humans, the nematode C.
Fisk Harold A, Pike Amanda N
doaj   +1 more source

Interplay of kinetochores and catalysts drives rapid assembly of the mitotic checkpoint complex

Nature Communications
The spindle assembly checkpoint (SAC) ensures mitotic exit occurs only after sister chromatid biorientation, but how this coordination is mechanistically achieved remains unclear.
Suruchi Sethi, Sabrina Ghetti, Verena Cmentowski, Teresa Benedetta Guerriere, Patricia Stege, Valentina Piano, Andrea Musacchio   +6 more
doaj   +1 more source

Human kinetochores are swivel joints that mediate microtubule attachments

eLife, 2016
Chromosome segregation is a mechanical process that requires assembly of the mitotic spindle – a dynamic microtubule-based force-generating machine.
Chris A Smith, Andrew D McAinsh, Nigel J Burroughs   +2 more
doaj   +1 more source

Causes and consequences of maternal age-related aneuploidy in oocytes: a review

Veterinární Medicína, 2013
Although a positive correlation between aneuploidy and maternal age was first reported almost a century ago, the underlying mechanisms remain mostly unknown.
A. Danylevska, J. Sebestova
doaj   +1 more source

Proteome of oocyte spindle identifies Ccdc69 regulates spindle assembly like “band-tightening spell”

Cellular and Molecular Life Sciences
Meiotic spindle is an intricate structure and required for chromosome segregation and the proper meiotic progression during oocyte maturation, and its function is regulated by a complex network of proteins located at spindle and its peripheral region ...
Jia-Ni Guo, Liu Zhu, Tie-Gang Meng, Yi-Na Zhang, Si-Min Sun, Xue-Mei Yang, Bing-Wang Zhao, Yi-Ke Lu, Yuan-Hong Xu, Wei Yue, Zhiming Han, Catherine C. L. Wong, Zhen-Bo Wang   +12 more
doaj   +1 more source

Spindle assembly checkpoint acquisition at the mid-blastula transition.

PLoS ONE, 2015
The spindle assembly checkpoint (SAC) maintains the fidelity of chromosome segregation during mitosis. Nonpathogenic cells lacking the SAC are typically only found in cleavage stage metazoan embryos, which do not acquire functional checkpoints until the ...
Maomao Zhang, Priyanka Kothari, Michael A Lampson   +2 more
doaj   +1 more source

Intermediate Filament Protein BFSP2 Controls Spindle Formation via HSC70‐Mediated Stabilization of CLTC During Oocyte meiosis

Advanced Science
As a major component of the cytoskeleton, intermediate filaments are generally considered to play a supporting role in mitotic cells. They also take part in the regulation of cell motility, proliferation, differentiation, and apoptosis.
Yu Li, Zihao Zhang, Yu Zhang, Bo Xiong
doaj   +1 more source

A pivot-tether model for nucleosome recognition by the chromosomal passenger complex

EMBO Reports
Spatial restriction of Aurora B to T3-phosphorylated histone H3 (H3pT3) nucleosomes adjacent to centromeres during prometaphase and metaphase enables it to phosphorylate proteins necessary for spindle assembly checkpoint signalling and biorientation of ...
Reinis R Ruza, Chyi Wei Chung, Danny B H Gold, Michela Serena, Emile Roberts, Ulrike Gruneberg, Francis A Barr   +6 more
doaj   +1 more source

Delayed Signaling in Mitotic Checkpoints: Biological Mechanisms and Modeling Perspectives

Biology
Time delays are intrinsic to mitotic regulation, particularly within the spindle assembly checkpoint (SAC) and the spindle position checkpoint (SPOC).
Bashar Ibrahim
doaj   +1 more source