Results 101 to 110 of about 1,399,702 (223)

Cellular response upon proliferation in the presence of an active mitotic checkpoint

Life Science Alliance, 2019
Cells that replicate with an active mitotic checkpoint remain capable to mount multiple times an efficient arrest, are bigger than unperturbed cells, rely more heavily on Cdh1, and have an altered protein expression profile. Eukaryotic cells treated with
Andrea Corno, Elena Chiroli, Fridolin Gross, Claudio Vernieri, Vittoria Matafora, Stefano Maffini, Marco Cosentino Lagomarsino, Angela Bachi, Andrea Ciliberto   +8 more
doaj   +1 more source

CD93—An emerging vascular target in cancer therapy

British Journal of Pharmacology, EarlyView.
Abstract CD93 is a single‐pass transmembrane glycoprotein that belongs to the C‐type lectin domain group XIV family of proteins. Although it is known to be expressed in other cell types, namely, in some subsets of immune cells, CD93 is primarily expressed on endothelial cells, where it acts as a crucial regulator of angiogenesis.
Beatriz de Alves Pereira, Stefano Barbera, Roberta Lugano, Anna Dimberg   +3 more
wiley   +1 more source

Establishment and mitotic characterization of new Drosophila acentriolar cell lines from DSas-4 mutant

Biology Open, 2013
Summary In animal cells the centrosome is commonly viewed as the main cellular structure driving microtubule (MT) assembly into the mitotic spindle apparatus.
Nicolas Lecland, Alain Debec, Audrey Delmas, Sara Moutinho-Pereira, Nicolas Malmanche, Anais Bouissou, Clémence Dupré, Aimie Jourdan, Brigitte Raynaud-Messina, Helder Maiato, Antoine Guichet   +10 more
doaj   +1 more source

Ploidy‐dependent modulation of DNA replication kinetics in Xenopus

The FEBS Journal, EarlyView.
Using an interspecies replication system with Xenopus frog species of different ploidy levels, we investigated how DNA replication adapts to polyploidization. While replication was slower in tetraploid than in diploid nuclei, dodecaploid nuclei unexpectedly replicated faster than tetraploid nuclei. Our findings show that increasing genome size does not
Hemalatha Narassimprakash, Olivier Haccard, Zhen Li, Nicolas Pollet, Kathrin Marheineke   +4 more
wiley   +1 more source

Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C

Nature Communications, 2019
During the spindle assembly checkpoint, the activity of the anaphase promoting complex/cyclosome (APC/C) is repressed, yet cyclin A2 evades the checkpoint and is targeted for degradation.
Suyang Zhang, Thomas Tischer, David Barford   +2 more
doaj   +1 more source

The Dual Face of Fusobacterium nucleatum in Cancer: Foe, Friend or Both?

Journal of Periodontal Research, EarlyView.
Fusobacterium nucleatum has established interactions with cancers in humans. However, contrary to a traditional view that these interactions are uniformly pro‐tumoural, recent evidence suggests a more nuanced role, where contact‐dependent and contact‐independent mechanisms may support either tumour progression or restriction depending on tumour site ...
Anjali Chander, Huile Lim, Gilad Bachrach, Miguel Reis Ferreira   +3 more
wiley   +1 more source

Bod1, a novel kinetochore protein required for chromosome biorientation [PDF]

, 2007
We have combined the proteomic analysis of Xenopus laevis in vitro–assembled chromosomes with RNA interference and live cell imaging in HeLa cells to identify novel factors required for proper chromosome segregation. The first of these is Bod1, a protein
McClelland, Sarah E., Khoudoli, Guennadi A., Swedlow, Jason R.; id_orcid, Andersen, Jens S., McAinsh, Andrew D., Andrew D. McAinsh, Swedlow, Jason R, Iain M. Porter, J. Julian Blow, Khoudoli, Guennadi A, Hunter, Christopher J., Blow, J. Julian; id_orcid, Guennadi A. Khoudoli, Jason R. Swedlow, Hunter, Christopher J, Sarah E. McClelland, Porter, Iain M, Porter, Iain M., Blow, J Julian, Andersen, Jens S; id_orcid, McClelland, Sarah E, Swedlow, Jason R., McAinsh, Andrew D, Blow, J. Julian, Jens S. Andersen, Christopher J. Hunter   +25 more
core   +1 more source

Identification and characterisation of spindle checkpoint silencing factors in Schizosaccharomyces pombe [PDF]

, 2020
In cell division, the spindle-assembly checkpoint (SAC) is an important mechanism which ensures proper segregation of chromosomes into daughter cells by delaying anaphase onset until all chromosomes are correctly attached to the mitotic spindle via ...
Soper Ní Chafraidh, Sadhbh
core   +1 more source

Smurf2 as a novel mitotic regulator: From the spindle assembly checkpoint to tumorigenesis

Cell Division, 2009
The execution of the mitotic program with high fidelity is dependent upon precise spatiotemporal regulation of posttranslational protein modifications.
Moore Finola E, Ray Dipankar, Osmundson Evan C, Kiyokawa Hiroaki   +3 more
doaj   +1 more source

Transcriptome Analysis Reveals Distinct Molecular Signatures Between Erosive and Non‐Erosive Oral Lichen Planus

Oral Diseases, EarlyView.
ABSTRACT Objectives To identify molecular mechanisms distinguishing the erosive subtype of oral lichen planus (EOLP) from the non‐erosive subtype (NEOLP) through transcriptomic analysis. Methods We analysed bulk RNA‐seq data from 30 buccal mucosa samples (13 EOLP, 17 NEOLP) using differential expression, Gene Set Enrichment Analysis (GSEA ...
Kisung Sheen, Chaerim Song, Kanghyun Kwon, Seoyeon Kim, Hye‐Ji Park, Man S. Kim   +5 more
wiley   +1 more source