Results 101 to 110 of about 36,138 (257)

Spindle assembly checkpoint and its regulators in meiosis [PDF]

Human Reproduction Update, 2011
BACKGROUND Meiosis is a unique form of cell division in which cells divide twice but DNA is duplicated only once. Errors in chromosome segregation during meiosis will result in aneuploidy, followed by loss of the conceptus during pregnancy or birth defects. During mitosis, cells utilize a mechanism called the spindle assembly checkpoint (SAC) to ensure
Shao-Chen, Sun, Nam-Hyung, Kim
openaire   +2 more sources

Bod1, a novel kinetochore protein required for chromosome biorientation [PDF]

, 2007
We have combined the proteomic analysis of Xenopus laevis in vitro–assembled chromosomes with RNA interference and live cell imaging in HeLa cells to identify novel factors required for proper chromosome segregation. The first of these is Bod1, a protein
McClelland, Sarah E., Khoudoli, Guennadi A., Swedlow, Jason R.; id_orcid, Andersen, Jens S., McAinsh, Andrew D., Andrew D. McAinsh, Swedlow, Jason R, Iain M. Porter, J. Julian Blow, Khoudoli, Guennadi A, Hunter, Christopher J., Blow, J. Julian; id_orcid, Guennadi A. Khoudoli, Jason R. Swedlow, Hunter, Christopher J, Sarah E. McClelland, Porter, Iain M, Porter, Iain M., Blow, J Julian, Andersen, Jens S; id_orcid, McClelland, Sarah E, Swedlow, Jason R., McAinsh, Andrew D, Blow, J. Julian, Jens S. Andersen, Christopher J. Hunter   +25 more
core   +1 more source

Loss of Kif18A Results in Spindle Assembly Checkpoint Activation at Microtubule-Attached Kinetochores.

Current Biology, 2018
The spindle assembly checkpoint (SAC) halts anaphase progression until all kinetochores have obtained bipolar, stable attachments to the mitotic spindle. Upon initial attachment, chromosomes undergo oscillatory movements to reach metaphase.
L. M. Janssen, Tessa V. Averink, V. Blomen, T. Brummelkamp, R. Medema, J. Raaijmakers   +5 more
semanticscholar   +1 more source

Hypoxia Induces a Mitotic Survival Advantage After Radiotherapy in Head and Neck Cancer Cells

International Journal of Cancer, Volume 159, Issue 4, Page 1042-1055, 15 August 2026.
Hypoxic tumor environments significantly limit radiotherapy effectiveness against cancer, particularly in head and neck squamous cell carcinoma (HNSCC). Here, the authors tracked hypoxic and post‐hypoxic cells using a hypoxia‐fate mapping system in human papillomavirus (HPV)‐positive and HPV‐negative HNSCC models.
Marilyn Wegge, Rüveyda Dok, Ludwig J. Dubois, Sandra Nuyts   +3 more
wiley   +1 more source

The current view for the silencing of the spindle assembly checkpoint [PDF]

Cell Cycle, 2014
Chromosome bipolar attachment is achieved when sister kinetochores are attached by microtubules emanating from opposite spindle poles, and this process is essential for faithful chromosome segregation during anaphase. A fundamental question in cell biology is how cells ensure that chromosome segregation only occurs after bipolar attachment.
Yanchang, Wang, Fengzhi, Jin, Ryan, Higgins, Kelly, McKnight   +3 more
openaire   +2 more sources

Axin-1 Regulates Meiotic Spindle Organization in Mouse Oocytes. [PDF]

PLoS ONE, 2016
Axin-1, a negative regulator of Wnt signaling, is a versatile scaffold protein involved in centrosome separation and spindle assembly in mitosis, but its function in mammalian oogenesis remains unknown.
Xiao-Qin He, Yue-Qiang Song, Rui Liu, Yu Liu, Fei Zhang, Zhen Zhang, Yu-Ting Shen, Lin Xu, Ming-Huang Chen, Ya-Long Wang, Bai-Hui Xu, Xiang-Jun Yang, Hai-Long Wang   +12 more
doaj   +1 more source

The T Cell Receptor: Molecular Sensor, Therapeutic Mediator and Probabilistic Driver of Adaptive Immunity

Immunological Reviews, Volume 340, Issue 1, July 2026.
ABSTRACT Advances in high‐throughput sequencing, single‐cell profiling, and genome engineering have transformed the study of T cell receptors (TCRs), enabling the identification and functional interrogation of antigen‐specific repertoires at an unprecedented scale.
Kilian Schober
wiley   +1 more source

TRAIP is a regulator of the spindle assembly checkpoint.

Journal of cell science, 2014
Accurate chromosome segregation during mitosis is temporally and spatially coordinated by fidelity-monitoring checkpoint systems. Deficiencies in these checkpoint systems can lead to chromosome segregation errors and aneuploidy, and promote tumorigenesis.
Chapard, Christophe, Meraldi, Patrick, Gleich, Tobias, Bachmann, Daniel, Hohl, Daniel, Huber, Marcel   +5 more
openaire   +4 more sources

No stretch for spindle assembly checkpoint [PDF]

The Journal of Cell Biology, 2008
![][1] Kinetochores (red) attach to the spindle (green), whereas chromatin (blue) is largely excluded. Dividing cells aren't quite as obsessed with quality control as previously thought, according to results from [O'Connell and colleagues][2].
openaire   +1 more source

The equatorial position of the metaphase plate ensures symmetric cell divisions

eLife, 2015
Chromosome alignment in the middle of the bipolar spindle is a hallmark of metazoan cell divisions. When we offset the metaphase plate position by creating an asymmetric centriole distribution on each pole, we find that metaphase plates relocate to the ...
Chia Huei Tan, Ivana Gasic, Sabina P Huber-Reggi, Damian Dudka, Marin Barisic, Helder Maiato, Patrick Meraldi   +6 more
doaj   +1 more source